Basic Information:

  VIRBase ID:  

HHID00092714

  Virus:  

Influenza A virus (H1N1)

  Host:  

Mus musculus

  Confidence Score:  

0.8847

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-29a-3p:  MIMAT0000535          Tbx21:  NM_019507     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-29a-3p	Tbx21
miRBase Accession/Entrez ID	MIMAT0000535	57765
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	Tbet//Tbly//Tblym//TBT1

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Tbx21	chr11:97098204-97098205(-) m6A 3'UTR       25683224 chr11:97098271-97098272(-) m6A 3'UTR       25683224 chr11:97098291-97098292(-) m6A 3'UTR       25683224 chr11:97098311-97098312(-) m6A 3'UTR       25683224 chr11:97098320-97098321(-) m6A 3'UTR       25683224//25456834 chr11:97098480-97098481(-) m6A 3'UTR       25683224//25456834//25569111//22608085 chr11:97098490-97098491(-) m6A 3'UTR       25683224//25456834//25569111//22608085 chr11:97098507-97098508(-) m6A 3'UTR       25683224//25456834//25569111//22608085 chr11:97098555-97098556(-) m6A 3'UTR       25683224//25456834//25569111//22608085 chr11:97098568-97098569(-) m6A 3'UTR       25683224//25456834//25569111//22608085 chr11:97098729-97098730(-) m6A 3'UTR       25456834//25569111 chr11:97098806-97098807(-) m6A CDS       25456834//25569111 chr11:97098892-97098893(-) m6A CDS       25683224//25456834//25569111 chr11:97098906-97098907(-) m6A CDS       25683224//25456834//25569111 chr11:97098972-97098973(-) m6A CDS       25683224//25456834//25569111 chr11:97098997-97098998(-) m6A CDS       25683224//25456834//25569111 chr11:97099010-97099011(-) m6A CDS       25683224//25456834//25569111 chr11:97115009-97115010(-) m6A CDS       25569111 chr11:97115051-97115052(-) m6A CDS       25569111

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-29a-3p	Axon DRG neurons     24381269 Cytoplasm Hepatocytes     29253196 Exosome Lewis lung carcinoma cells     22753494 Exosome Serum     28160157 Exosome Mast cells     17486113 Exosome B6 BMDCs     22031862 Exosome Mouse hypothalamic neuronal cell line (GT1-7)     22965126 Exosome Bone marrow-derived macrophages     25159140 Extracellular vesicle Dendritic cells|T cells     22821563 Mitochondrion Heart tissue (subsarcolemmal and interfibrillar)     26377859 Mitochondrion Liver cells     27563705 Mitochondrion Liver tissue     20733615

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-29a-3p
Interactor2: Tbx21

Evidence Support:

Strong-Evidence	Luciferase reporter assay
Weak-Evidence	Microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	23731466	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	CD4(+) T cells	Interactor2 expression	Downregulation
Description	Both miR-29a and miR-29b could repress IFN-gamma production by direct targeting of both T-box transcription factor T-bet and Eomesodermin(Eomes), two transcription factors known to induce IFN-gamma production.