Basic Information:

  VIRBase ID:  

HHID00092713

  Virus:  

Influenza A virus (H1N1)

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-200a-3p:  MIMAT0000519          Stat4:  NM_011487     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-200a-3p	Stat4
miRBase Accession/Entrez ID	MIMAT0000519	20849
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	-

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Stat4	chr1:52008659-52008660(+) m6A 5'UTR//exon//intron       24981863 chr1:52008685-52008686(+) m6A 5'UTR//exon//intron       24981863 chr1:52068789-52068790(+) m6A CDS//exon       - chr1:52068804-52068805(+) m6A CDS//exon       - chr1:52105702-52105703(+) m6A CDS//exon       24981863 chr1:52105747-52105748(+) m6A CDS//exon       24981863 chr1:52105770-52105771(+) m6A CDS//exon       24981863 chr1:52106948-52106949(+) m6A 3'UTR//exon       24981863 chr1:52106974-52106975(+) m6A 3'UTR//exon       24981863 chr1:52107119-52107120(+) m6A 3'UTR//exon       25456834//24981863 chr1:52107133-52107134(+) m6A 3'UTR//exon       25456834//24981863 chr1:52107146-52107147(+) m6A 3'UTR//exon       25456834//24981863 chr1:52107174-52107175(+) m6A 3'UTR//exon       25456834//24981863 chr1:52107186-52107187(+) m6A 3'UTR//exon       25456834//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-200a-3p	Exosome Serum     28160157

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-200a-3p
Interactor2: Stat4

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	20071585	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	MDCK cells	Interactor2 expression	None
Description	Our analysis of microRNA targets indicated that the type I IFN pathway was subject to microRNA-mediated regulation, since key genes in this pathway, such as IFNAR1 and STAT2, are direct targets of miR-200a, and their expression was inversely correlated with the expression of this microRNA (Fig.4).