Detail Information

Basic Information:


  VIRBase ID:  

HHID00092701

  Virus:  

Influenza A virus (H1N1)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-769-5p:           MAPK11:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-769-5p MAPK11
miRBase
Accession/Entrez ID		 MIMAT0003886 5600
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - p38-2//P38B//p38Beta//P38BETA2//PRKM11//SAPK2//SAPK2B

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-769-5p
rs1270950121 chr19:46018982    T/C
rs375088831 chr19:46018978    G/C
rs760735520 chr19:46018969    C/T
rs910184294 chr19:46018976    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MAPK11
chr22:50702273-50702274(-) m6A 3'UTR       24284625//24209618//27371828
chr22:50702418-50702419(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27371828//22608085
chr22:50702424-50702425(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27371828//22608085
chr22:50702430-50702431(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27371828//22608085
chr22:50702517-50702518(-) m6A 3'UTR//intron       24209618//25456834//24981863//27371828
chr22:50702586-50702587(-) m6A 3'UTR//intron       24209618//27371828
chr22:50702830-50702831(-) m6A 3'UTR//intron       24209618//25456834//27371828
chr22:50702884-50702885(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr22:50702957-50702958(-) m6A 3'UTR//intron       24284625//25456834//24981863//27371828//27773536//22608085
chr22:50702967-50702968(-) m6A 3'UTR//intron       24284625//25456834//24981863//27371828//27773536//22608085
chr22:50703103-50703104(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//27371828//22608085
chr22:50703208-50703209(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27371828//22608085
chr22:50703253-50703254(-) m6A 3'UTR       24284625//24981863//27371828//22608085
chr22:50703267-50703268(-) m6A 3'UTR       24284625//24981863//27371828//22608085
chr22:50703889-50703890(-) m6A 3'UTR//CDS       27371828
chr22:50703916-50703917(-) m6A 3'UTR//CDS       27371828
chr22:50704045-50704046(-) m6A 3'UTR//CDS       27773535
chr22:50704082-50704083(-) m6A 3'UTR//CDS       27773535
chr22:50704733-50704734(-) m6A 3'UTR//CDS       27371828
chr22:50705568-50705569(-) m6A CDS//exon       24284625//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-769-5p
Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
Exosome Plasma     23663360
Exosome B lymphoblastoid cells|Endothelial cells|Lymphoma tissue|Mast cells|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
MAPK11
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-769-5p
8-Aminoadenosine 96851 Drug resistant
Morpholine-N-dithiocarbamate 72675 Drug sensitive
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Benzamide riboside 458027 Drug sensitive
Predorine 333830 Drug sensitive
Stannane, trimethyl[(4-morpholinylthioxomethyl)thio]- 300936 Drug sensitive
Hydrazine sulfate 24842 Drug sensitive
2h-naphtho[1,2-b]pyran-2-one, 9-hydroxy-4-phenyl- - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-769-5p
Hyaluronidase 91820602 Drug interaction    RC00006691
Vorinostat 5311 Drug interaction    RC00006685
Eloxatine 5310940 Drug interaction    RC00006689
Paclitaxel 36314 Drug interaction    RC00006687
Doxorubicin 31703 Drug interaction    RC00006686
Tamoxifen 2733526 Drug interaction    RC00006688
Verapamil 2520 Drug interaction    RC00006684
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00006690
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-769-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124
Gefitinib 123631       30601026

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-769-5p
Interactor2: MAPK11

Evidence Support:


Weak-Evidence Microarray
Prediction-Evidence miRanda//RNA22//Targetscan
Support Database ViRBase

References:


PMID 23731466 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line PBMCs Interactor2 expression Downregulation
Description P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients.

Starting a new search, please wait ...