Detail Information

Basic Information:


  VIRBase ID:  

HHID00092671

  Virus:  

Influenza A virus (H1N1)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-31-5p:           MAPK13:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-31-5p MAPK13
miRBase
Accession/Entrez ID		 MIMAT0000089 5603
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - MAPK 13//MAPK-13//p38delta//PRKM13//SAPK4

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-31-5p
rs368583676 chr9:21512165    C/T
rs1475828657 chr9:21512176    C/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MAPK13
chr6:36102409(+) A-I      intronic
chr6:36102309(+) A-I      intronic
chr6:36102713(+) A-I      intronic
chr6:36102641(+) A-I      intronic
chr6:36104892(+) A-I      intronic
chr6:36102698(+) A-I      intronic
chr6:36102270(+) A-I      intronic
chr6:36102670(+) A-I      intronic
chr6:36102614(+) A-I      intronic
chr6:36102249(+) A-I      intronic
chr6:36102427(+) A-I      intronic
chr6:36102684(+) A-I      intronic
chr6:36102372(+) A-I      intronic
chr6:36102712(+) A-I      intronic
chr6:36102451(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MAPK13
chr6:36102198(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MAPK13
chr6:36098407-36098408(+) m6A CDS//exon       -
chr6:36098428-36098429(+) m6A CDS//exon       -
chr6:36098677-36098678(+) m6A exon//intron       -
chr6:36098697-36098698(+) m6A exon//intron       -
chr6:36098713-36098714(+) m6A exon//intron       -
chr6:36106508-36106509(+) m6A CDS       -
chr6:36106751-36106752(+) m6A 3'UTR//CDS       24284625//24981863
chr6:36106800-36106801(+) m6A 3'UTR//CDS       24284625//25456834//24981863
chr6:36106809-36106810(+) m6A 3'UTR//CDS       24284625//25456834
chr6:36107094-36107095(+) m6A 3'UTR//CDS       25456834//24981863//22608085
chr6:36107118-36107119(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22608085
chr6:36107152-36107153(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr6:36107180-36107181(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr6:36107193-36107194(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr6:36107214-36107215(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr6:36107252-36107253(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr6:36107325-36107326(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr6:36107355-36107356(+) m6A 3'UTR       24284625//25456834//22608085
chr6:36107497-36107498(+) m6A 3'UTR       25456834
chr6:36107512-36107513(+) m6A 3'UTR       25456834
chr6:36107520-36107521(+) m6A 3'UTR       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-31-5p
Apoptotic body Human umbilical vein endothelial cells     19996457
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Human cervical cancer cell line (HeLa)     29492481
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Endothelial cells|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
MAPK13
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-31-5p
Midostaurin 9829523 Drug sensitive
Dichlorodipropylstannane 93562 Drug resistant
Pyrazolo[1,5-b]pyridazine deriv. 40 6539382 Drug sensitive
(Z)-4-Bromo-4-iodo-3-phenylbut-3-en-2-one 5467656 Drug resistant
Erioflorin acetate 5281443 Drug resistant
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug sensitive
2,5-Bis(3-Amino-2,4,6-trinitrophenyl)-1,3,4-thiadiazole 385374 Drug resistant
7-Chloro-6-(2-fluoroethylamino)quinoline-5,8-dione 379079 Drug resistant
4-(1-Benzofuran-2-yl)-7-methoxychromen-2-one 364364 Drug sensitive
Girolline 362388 Drug sensitive
4-Chloro-5-phenoxy-3H-1,2-dithiole-3-thione 16766044 Drug resistant
2,2-Diethyl-6-(hydroxymethyl)-4,6,7,7a-tetrahydro-3aH-[1,3,2]dioxastannolo[4,5-c]pyran-4,7-diol 16683462 Drug resistant
Inosine dialdehyde 135400916 Drug resistant
Melampodinin 11953936 Drug resistant
3-Bromo-4-(3,3-dimethyl-but-1-ynyl)-2(5H)-furanone 11413833 Drug sensitive
7h-5,6-dithioleno[4,3-d]uracil - Drug resistant
benzene, 1,1'-[(1,3-butadiene-1,4-diyl)sulfonyl]bis - Drug resistant
benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug resistant
[bis(aminomethyl)diethylsilane]dichloroplatinum (ii) - Drug resistant
5-hydroxyamino camptothecin - Drug resistant
indole-2,3-dione, 5-methyl-, 3-[(o-nitrophenyl)hydrazone] - Drug sensitive
antineoplastic-d655481 - Drug sensitive
tp4ek - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-31-5p
10-Hydroxycamptothecin 97226 Drug interaction    RC00000917
Gemcitabine 60750 Drug interaction    RC00000916
Vincristine 5978 Drug interaction    RC00000910
Sunitinib 5329102 Drug interaction    RC00000925
Vorinostat 5311 Drug interaction    RC00000924
Eloxatine 5310940 Drug interaction    RC00000923
(5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate 5280427 Drug interaction    RC00000922
Decitabine 451668 Drug interaction    RC00000921
Trichostatin A 444732 Drug interaction    RC00000920
Staurosporine 44259 Drug interaction    RC00000915
Etoposide 36462 Drug interaction    RC00000914
Paclitaxel 36314 Drug interaction    RC00000913
5-Fluorouracil 3385 Drug interaction    RC00000909
Enoxacin 3229 Drug interaction    RC00000908
Doxorubicin 31703 Drug interaction    RC00000912
Valproic acid 3121 Drug interaction    RC00000907
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000906
Verapamil 2520 Drug interaction    RC00000905
Calcium sulfate 24497 Drug interaction    RC00000911
Docetaxel 148124 Drug interaction    RC00000919
Gefitinib 123631 Drug interaction    RC00000918
Succinic acid 1110 Drug interaction    RC00000904
platinum-based doublet chemotherapy - Drug interaction    RC00000926
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00000927
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-31-5p
Oxaliplatin 9887053       30400960
Cisplatin 5702198       25356050
5-Fluorouracil 3385       25356050

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-31-5p
Interactor2: MAPK13

Evidence Support:


Weak-Evidence Microarray
Prediction-Evidence miRanda//RNA22//Targetscan
Support Database ViRBase

References:


PMID 23731466 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line PBMCs Interactor2 expression Downregulation
Description P38 MAPKs(MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p, which were all down expressed in H1N1 critically ill patients.

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