Detail Information

Basic Information:


  VIRBase ID:  

HHID00092663

  Virus:  

Influenza A virus (A/WSN/1933(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:           PPP1R14B:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1275 PPP1R14B
miRBase
Accession/Entrez ID		 MIMAT0005929 26472
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PHI-1//PLCB3N//PNG//SOM172

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1275
rs372458638 chr6:34000019    A/AAAACC
rs377188203 chr6:34000023    C/T
rs557928121 chr6:34000019    A/T
rs758811783 chr6:34000022    G/A
rs761034364 chr6:34000017    AGAC/A
rs370361021 chr6:34000029    C/A
rs370361021 chr6:34000029    C/T
rs374728385 chr6:34000032    C/A
rs374728385 chr6:34000032    C/G
rs747378297 chr6:34000028    C/T
rs772691699 chr6:34000033    A/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PPP1R14B
chr11:64012144-64012145(-) m6A 3'UTR       27773535//27371828
chr11:64012188-64012189(-) m6A 3'UTR       27773535//27371828//22575960
chr11:64012271-64012272(-) m6A CDS       27773535//27371828//27773536//22575960
chr11:64012410-64012411(-) m6A CDS       27773535//27371828//27773536//22575960
chr11:64012712-64012713(-) m6A 5'UTR//CDS       27773535//27371828//27773536//22575960
chr11:64012741-64012742(-) m6A 5'UTR//CDS       27773535//27371828//27773536//22575960
chr11:64013538-64013539(-) m6A 5'UTR//intron       24981863
chr11:64014070-64014071(-) m6A CDS       24284625//24209618//27773536//22575960
chr11:64014137-64014138(-) m6A CDS       24284625//24209618//27773536
chr11:64014363-64014364(-) m6A 5'UTR       24209618//25456834//24981863
chr11:64014411-64014412(-) m6A 5'UTR       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1275
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
Mitochondrion HeLa cells     27396686
Mitochondrion HeLa cells     27563705
Mitochondrion Cell line (HeLa)     21695135
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus HeLa cells     23940654
PPP1R14B
Exosome Blood     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1275
Gemcitabine 60750 Drug interaction    RC00007825
Vincristine 5978 Drug interaction    RC00007823
Eloxatine 5310940 Drug interaction    RC00007826
Paclitaxel 36314 Drug interaction    RC00007824
5-Fluorouracil 3385 Drug interaction    RC00007822
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821
Marine fungal metabolite 1386A - Drug interaction    RC00007827
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1275
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1275
Interactor2: PPP1R14B

Evidence Support:


Weak-Evidence Microarray
Prediction-Evidence miRWalk//Targetscan
Support Database ViRBase

References:


PMID 22822053 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line A549 cells//BEAS-2B cells//Vero cells Interactor2 expression Downregulation
Description Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems.

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