Detail Information

Basic Information:


  VIRBase ID:  

HHID00092662

  Virus:  

Influenza A virus (A/WSN/1933(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:           MAPK3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1275 MAPK3
miRBase
Accession/Entrez ID		 MIMAT0005929 5595
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ERK-1//ERK1//ERT2//HS44KDAP//HUMKER1A//p44-ERK1//p44-MAPK//P44ERK1//P44MAPK//PRKM3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1275
rs372458638 chr6:34000019    A/AAAACC
rs377188203 chr6:34000023    C/T
rs557928121 chr6:34000019    A/T
rs758811783 chr6:34000022    G/A
rs761034364 chr6:34000017    AGAC/A
rs370361021 chr6:34000029    C/A
rs370361021 chr6:34000029    C/T
rs374728385 chr6:34000032    C/A
rs374728385 chr6:34000032    C/G
rs747378297 chr6:34000028    C/T
rs772691699 chr6:34000033    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MAPK3
chr16:30132704(-) A-I      intronic
chr16:30132703(-) A-I      intronic
chr16:30130225(-) A-I      intronic
chr16:30132695(-) A-I      intronic
chr16:30132645(-) A-I      intronic
chr16:30132669(-) A-I      intronic
chr16:30132627(-) A-I      intronic
chr16:30132687(-) A-I      intronic
chr16:30127733(-) A-I      intronic
chr16:30126329(-) A-I      intronic
chr16:30126324(-) A-I      intronic
chr16:30132073(-) A-I      intronic
chr16:30130376(-) A-I      intronic
chr16:30130380(-) A-I      intronic
chr16:30130335(-) A-I      intronic
chr16:30132242(-) A-I      intronic
chr16:30132250(-) A-I      intronic
chr16:30130291(-) A-I      intronic
chr16:30132271(-) A-I      intronic
chr16:30130239(-) A-I      intronic
chr16:30132278(-) A-I      intronic
chr16:30132284(-) A-I      intronic
chr16:30132519(-) A-I      intronic
chr16:30132535(-) A-I      intronic
chr16:30132547(-) A-I      intronic
chr16:30132568(-) A-I      intronic
chr16:30132620(-) A-I      intronic
chr16:30132145(-) A-I      intronic
chr16:30132625(-) A-I      intronic
chr16:30127708(-) A-I      intronic
chr16:30131381(-) A-I      intronic
chr16:30126355(-) A-I      intronic
chr16:30126354(-) A-I      intronic
chr16:30130300(-) A-I      intronic
chr16:30132256(-) A-I      intronic
chr16:30130297(-) A-I      intronic
chr16:30131324(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MAPK3
chr16:30130300(-) A-I intron -    22327324

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MAPK3
chr16:30125627-30125628(-) m6A 3'UTR//exon       27773535
chr16:30125652-30125653(-) m6A 3'UTR//exon       27773535
chr16:30125688-30125689(-) m6A 3'UTR//exon       27773535
chr16:30125840-30125841(-) m6A 3'UTR//exon       27773536
chr16:30125963-30125964(-) m6A 3'UTR//exon       24284625//25456834//24981863//27371828//27773536
chr16:30125981-30125982(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828//27773536
chr16:30125996-30125997(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828//27773536
chr16:30126958-30126959(-) m6A 3'UTR//exon//intron       24284625//27773535//27371828//27773536
chr16:30126963-30126964(-) m6A 3'UTR//exon//intron       24284625//27773535//27371828//27773536
chr16:30127982-30127983(-) m6A 3'UTR//exon       -
chr16:30128026-30128027(-) m6A 3'UTR//CDS//exon       27773535
chr16:30128308-30128309(-) m6A CDS//exon       27773535
chr16:30128393-30128394(-) m6A exon//intron       27773535
chr16:30128464-30128465(-) m6A CDS//intron       27773535
chr16:30129833-30129834(-) m6A 5'UTR//CDS//exon       24284625//27773535
chr16:30129844-30129845(-) m6A 5'UTR//CDS//exon       24284625//27773535//27371828
chr16:30133183-30133184(-) m6A 5'UTR//CDS//exon       27371828
chr16:30133259-30133260(-) m6A 5'UTR//CDS//exon       27371828
chr16:30133266-30133267(-) m6A 5'UTR//CDS//exon       27371828
chr16:30133301-30133302(-) m6A 5'UTR//CDS//exon       24209618//27371828//27773536
chr16:30133375-30133376(-) m6A 5'UTR//intron       24209618//27371828//27773536
chr16:30134481-30134482(-) m6A CDS//intron       25456834//24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1275
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
Mitochondrion HeLa cells     27396686
Mitochondrion HeLa cells     27563705
Mitochondrion Cell line (HeLa)     21695135
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus HeLa cells     23940654
MAPK3
Chromatin K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1275
Gemcitabine 60750 Drug interaction    RC00007825
Vincristine 5978 Drug interaction    RC00007823
Eloxatine 5310940 Drug interaction    RC00007826
Paclitaxel 36314 Drug interaction    RC00007824
5-Fluorouracil 3385 Drug interaction    RC00007822
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821
Marine fungal metabolite 1386A - Drug interaction    RC00007827
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1275
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1275
Interactor2: MAPK3

Evidence Support:


Weak-Evidence Microarray
Prediction-Evidence miRWalk//Targetscan
Support Database ViRBase

References:


PMID 22822053 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line A549 cells//BEAS-2B cells//Vero cells Interactor2 expression Downregulation
Description Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems.

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