Detail Information

Basic Information:


  VIRBase ID:  

HHID00092661

  Virus:  

Influenza A virus (A/WSN/1933(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:           IRAK1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1275 IRAK1
miRBase
Accession/Entrez ID		 MIMAT0005929 3654
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IRAK//pelle

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1275
rs372458638 chr6:34000019    A/AAAACC
rs377188203 chr6:34000023    C/T
rs557928121 chr6:34000019    A/T
rs758811783 chr6:34000022    G/A
rs761034364 chr6:34000017    AGAC/A
rs370361021 chr6:34000029    C/A
rs370361021 chr6:34000029    C/T
rs374728385 chr6:34000032    C/A
rs374728385 chr6:34000032    C/G
rs747378297 chr6:34000028    C/T
rs772691699 chr6:34000033    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IRAK1
chrX:153279602(-) A-I      NonSyn:His->Arg
chrX:153276588(-) A-I      3'UTR
chrX:153276744(-) A-I      3'UTR
chrX:153276791(-) A-I      3'UTR
chrX:153276814(-) A-I      3'UTR
chrX:153276750(-) A-I      3'UTR
chrX:153276813(-) A-I      3'UTR
chrX:153276668(-) A-I      3'UTR
chrX:153276687(-) A-I      3'UTR
chrX:153276787(-) A-I      3'UTR
chrX:153276634(-) A-I      3'UTR
chrX:153276650(-) A-I      3'UTR
chrX:153280137(-) A-I      intronic
chrX:153279877(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED IRAK1
chrX:153276566(-) A-G exon 3'UTR    22484847
chrX:153276668(-) A-G exon 3'UTR    22484847
chrX:153276687(-) A-G exon 3'UTR    22484847
chrX:153276787(-) A-G exon 3'UTR    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IRAK1
chrX:153276155-153276156(-) m6A 3'UTR       22575960
chrX:153276172-153276173(-) m6A 3'UTR//exon       22575960
chrX:153276185-153276186(-) m6A 3'UTR//exon       22575960
chrX:153276230-153276231(-) m6A 3'UTR//exon       22575960
chrX:153276244-153276245(-) m6A 3'UTR//exon       22575960
chrX:153276407-153276408(-) m6A 3'UTR//CDS//intron       -
chrX:153276542-153276543(-) m6A 3'UTR//CDS//intron       27773535
chrX:153276562-153276563(-) m6A 3'UTR//CDS//intron       27773535
chrX:153276705-153276706(-) m6A 3'UTR//intron       24209618//22575960
chrX:153276733-153276734(-) m6A 3'UTR//intron       24284625//24209618//22575960
chrX:153276756-153276757(-) m6A 3'UTR//intron       24284625//24209618//22575960
chrX:153276912-153276913(-) m6A 3'UTR//intron       24284625//24209618//25456834//27371828//27773536//22608085
chrX:153277036-153277037(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960
chrX:153277128-153277129(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chrX:153277349-153277350(-) m6A 3'UTR//CDS//intron       24284625//24209618//27773536//22575960
chrX:153277354-153277355(-) m6A 3'UTR//CDS//intron       24284625//24209618//27773536//22575960
chrX:153278014-153278015(-) m6A 3'UTR//CDS//intron       24284625//24209618//26404942//27773536//22575960
chrX:153278552-153278553(-) m6A 3'UTR//CDS//intron       24284625//27371828//27773536//22575960
chrX:153278591-153278592(-) m6A 3'UTR//CDS//intron       24284625//27371828//27773536//22575960
chrX:153278789-153278790(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536
chrX:153279595-153279596(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536
chrX:153279724-153279725(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27371828//27773536
chrX:153279784-153279785(-) m6A exon//intron       24284625//24981863//27371828//27773536//22575960
chrX:153279792-153279793(-) m6A exon//intron       24284625//24981863//27371828//27773536//22575960
chrX:153279815-153279816(-) m6A exon//intron       24284625//24981863//27371828//27773536//22575960
chrX:153281493-153281494(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27371828//27773536//22575960
chrX:153281535-153281536(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536//22575960
chrX:153281906-153281907(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536//22575960
chrX:153281912-153281913(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536//22575960
chrX:153281976-153281977(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536//22575960
chrX:153281982-153281983(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536//22575960
chrX:153282050-153282051(-) m6A 3'UTR//CDS//exon//intron       24284625//27773536//22575960
chrX:153282408-153282409(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153282432-153282433(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153282477-153282478(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153283472-153283473(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153283547-153283548(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153283556-153283557(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153283787-153283788(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153284080-153284081(-) m6A CDS//exon//intron       24284625//22575960
chrX:153284129-153284130(-) Am CDS//exon//intron       -
chrX:153284268-153284269(-) m6A exon//intron       24284625
chrX:153284274-153284275(-) m6A exon//intron       24284625
chrX:153284390-153284391(-) m6A exon//intron       24284625
chrX:153284511-153284512(-) m6A CDS       24284625//27773536//22575960
chrX:153284895-153284896(-) m6A CDS       24284625//27773536//22575960
chrX:153285025-153285026(-) m6A CDS       24284625//27773536//22575960
chrX:153285336-153285337(-) m6A 5'UTR       24209618//24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1275
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
Mitochondrion HeLa cells     27396686
Mitochondrion HeLa cells     27563705
Mitochondrion Cell line (HeLa)     21695135
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus HeLa cells     23940654
IRAK1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1275
Gemcitabine 60750 Drug interaction    RC00007825
Vincristine 5978 Drug interaction    RC00007823
Eloxatine 5310940 Drug interaction    RC00007826
Paclitaxel 36314 Drug interaction    RC00007824
5-Fluorouracil 3385 Drug interaction    RC00007822
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821
Marine fungal metabolite 1386A - Drug interaction    RC00007827
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1275
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1275
Interactor2: IRAK1

Evidence Support:


Weak-Evidence Microarray
Prediction-Evidence miRWalk//Targetscan
Support Database ViRBase

References:


PMID 22822053 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line A549 cells//BEAS-2B cells//Vero cells Interactor2 expression Downregulation
Description Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems.

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