Detail Information

Basic Information:


  VIRBase ID:  

HHID00092640

  Virus:  

Influenza A virus (A/WSN/1933(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-132-3p:           DCBLD2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-132-3p DCBLD2
miRBase
Accession/Entrez ID		 MIMAT0000426 131566
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CLCP1//ESDN

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-132-3p
rs1022001830 chr17:2049934    A/G
rs1392699403 chr17:2049936    G/C
rs1431105016 chr17:2049930    G/A
rs751170675 chr17:2049941    T/C
rs1173831908 chr17:2049944    A/T
rs1211938237 chr17:2049947    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DCBLD2
chr3:98563278(-) A-I      intronic
chr3:98563502(-) A-I      intronic
chr3:98563488(-) A-I      intronic
chr3:98563456(-) A-I      intronic
chr3:98563439(-) A-I      intronic
chr3:98563434(-) A-I      intronic
chr3:98563330(-) A-I      intronic
chr3:98564832(-) A-I      intronic
chr3:98583687(-) A-I      intronic
chr3:98563270(-) A-I      intronic
chr3:98560873(-) A-I      intronic
chr3:98541809(-) A-I      intronic
chr3:98550032(-) A-I      intronic
chr3:98554395(-) A-I      intronic
chr3:98567891(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DCBLD2
chr3:98515206-98515207(-) m6A 3'UTR       26404942
chr3:98515221-98515222(-) m6A 3'UTR       26404942
chr3:98515263-98515264(-) m6A 3'UTR       26404942
chr3:98515316-98515317(-) m6A 3'UTR       26404942
chr3:98515619-98515620(-) m6A 3'UTR       26404942
chr3:98515688-98515689(-) m6A 3'UTR       26404942
chr3:98515755-98515756(-) m6A 3'UTR       26404942
chr3:98515841-98515842(-) m6A 3'UTR       26404942
chr3:98515996-98515997(-) m6A 3'UTR       26404942
chr3:98516045-98516046(-) m6A 3'UTR       26404942
chr3:98516078-98516079(-) m6A 3'UTR       26404942
chr3:98516327-98516328(-) m6A 3'UTR       26404942
chr3:98516393-98516394(-) m6A 3'UTR       26404942
chr3:98516405-98516406(-) m6A 3'UTR       26404942
chr3:98516418-98516419(-) m6A 3'UTR       26404942
chr3:98516425-98516426(-) m6A 3'UTR       26404942
chr3:98516820-98516821(-) m6A 3'UTR       26404942
chr3:98516841-98516842(-) m6A 3'UTR       26404942
chr3:98516889-98516890(-) m6A 3'UTR       26404942
chr3:98517098-98517099(-) m6A 3'UTR       26404942
chr3:98517178-98517179(-) m6A 3'UTR       26404942
chr3:98517295-98517296(-) m6A 3'UTR       26404942
chr3:98517881-98517882(-) m6A 3'UTR       24284625//24981863//26404942//22608085
chr3:98517978-98517979(-) m6A 3'UTR       26404942//27773535
chr3:98518073-98518074(-) m6A 3'UTR       26404942//27773535
chr3:98518379-98518380(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:98518403-98518404(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:98518426-98518427(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:98518492-98518493(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:98518539-98518540(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr3:98518591-98518592(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr3:98518623-98518624(-) m6A CDS       24209618//24981863//26404942//27773535//22608085
chr3:98519503-98519504(-) m6A CDS//exon       26404942
chr3:98519514-98519515(-) m6A CDS//exon       26404942
chr3:98520451-98520452(-) m6A CDS//exon       27773535
chr3:98520482-98520483(-) m6A CDS//exon       27773535
chr3:98520598-98520599(-) m6A exon//intron       27773535
chr3:98520606-98520607(-) m6A exon//intron       27773535
chr3:98520615-98520616(-) m6A exon//intron       27773535
chr3:98520649-98520650(-) m6A exon//intron       27773535
chr3:98520654-98520655(-) m6A exon//intron       27773535
chr3:98520661-98520662(-) m6A exon//intron       27773535
chr3:98520673-98520674(-) m6A exon//intron       27773535
chr3:98520690-98520691(-) m6A exon//intron       27773535
chr3:98530095-98530096(-) m6A CDS//exon       24284625//24981863//26404942//27773535
chr3:98530100-98530101(-) m6A CDS//exon       24284625//24981863//26404942//27773535
chr3:98530340-98530341(-) m6A CDS//exon       24284625//24981863//26404942//27773535
chr3:98530358-98530359(-) m6A CDS//exon       24284625//24981863//26404942//27773535
chr3:98530384-98530385(-) m6A CDS//exon       24284625//24981863//26404942//27773535
chr3:98531312-98531313(-) m6A CDS//exon       26404942
chr3:98531399-98531400(-) m6A exon//intron       24981863
chr3:98531405-98531406(-) m6A exon//intron       24981863
chr3:98536647-98536648(-) m6A CDS//exon       24981863//26404942
chr3:98538121-98538122(-) m6A CDS//exon       24981863//26404942
chr3:98538127-98538128(-) m6A CDS//exon       24981863//26404942
chr3:98538151-98538152(-) m6A CDS//exon       24981863//26404942
chr3:98538161-98538162(-) m6A CDS//exon       24981863//26404942
chr3:98538183-98538184(-) m6A CDS//exon       26404942
chr3:98538249-98538250(-) m6A CDS       26404942
chr3:98539097-98539098(-) m6A CDS       26404942
chr3:98539128-98539129(-) m6A CDS       26404942
chr3:98568411-98568412(-) m6A CDS//exon       26404942
chr3:98600392-98600393(-) m6A CDS//exon//intron       26404942
chr3:98600542-98600543(-) m6A 5'UTR//CDS//exon//intron       26404942
chr3:98600553-98600554(-) m6A 5'UTR//CDS//exon//intron       26404942
chr3:98600569-98600570(-) m6A 5'UTR//CDS//exon//intron       26404942
chr3:98600597-98600598(-) m6A 5'UTR//CDS//exon//intron       26404942//27773535
chr3:98609242-98609243(-) m6A 5'UTR//intron       26404942//27773535
chr3:98614089-98614090(-) m6A exon//intron       27773535
chr3:98620185-98620186(-) m6A 5'UTR       24209618//27773536
chr3:98620417-98620418(-) m6A 5'UTR       24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-132-3p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Ovarian follicular fluid     22116803
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Peripheral blood     32785072
Exosome Blood|Endothelial cells|Mast cells     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Human neuroblastoma cell line (SK-N-AS)     27583637
DCBLD2
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-132-3p
Hedamycin 98033 Drug sensitive
Gardenin B 96539 Drug sensitive
1-(2-Thiazolylazo)-2-naphthol 93572 Drug resistant
5-Methyl-1,10-phenanthroline 72791 Drug resistant
2-Amino-3H-phenoxazin-3-one 72725 Drug sensitive
4,4'-Bis(dimethylamino)thiobenzophenone 71045 Drug sensitive
Resorufin 69462 Drug sensitive
1-(2-Pyridylazo)-2-naphthol 6825 Drug resistant
Tributyrin 6050 Drug resistant
(Z)-6-(2-(Pyridin-2-ylmethylene)hydrazinyl)-9H-purine 60147744 Drug resistant
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-(1H-pyrrol-2-yl)thieno[3,2-d]pyrimidin-4-amine;hydrochloride 57401575 Drug resistant
Ethaverine hydrochloride 5702159 Drug sensitive
Dezaguanine 55710 Drug resistant
5,10-Dimethoxybenzo[g]quinolin-2(1H)-one 54612875 Drug sensitive
Bindschedler's green 458960 Drug sensitive
2-(3-Chloropropyloxy)naphthazarin 378771 Drug sensitive
4-Methylthio-N-(3,4,5-trimethoxybenzyl)aniline 373808 Drug sensitive
Antineoplastic-642316 369949 Drug sensitive
Diethoxybis(1,4-naphthochinone-2-olato)titanium(IV) 368297 Drug sensitive
Miltefosine 3599 Drug resistant
2,3-Dimethylbenzo[g]quinoxaline-5,10-dione 353644 Drug sensitive
Chelerythrine 2703 Drug sensitive
2-(7-Aminotriazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)oxolane-3,4-diol 251928 Drug resistant
Fluorene, 9-bromo-2,4,7-trichloro- 248608 Drug sensitive
1,2-Benzo-8-(L-alanyl)-3-phenoxazone nitrate salt 24202491 Drug sensitive
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive
Mitomycin C methylamine 213803 Drug sensitive
3-Amino-N-(2-fluorophenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide 1856915 Drug sensitive
Erlotinib 176870 Drug resistant
N-(4-(1-Aziridinyl)butyl)-1,3-propanediamine 160395 Drug resistant
Triethyltin chloride 13820 Drug sensitive
Eriochrome black t 135465089 Drug resistant
Cytochalasin q 11970174 Drug resistant
Cinnoline, 4-nitro-, 1-oxide 100397 Drug resistant
1,6:2,3-dianhydro-4-o-benzyl-.beta.-d-mannopyranose - Drug resistant
ethanol, 2-[4-(2,2':6',2-terpyridin-4'-yl)phenoxy]- - Drug resistant
ethanone, 1-(2-pyrimidinyl)-, (2-benzoxazolyl)hydrazone - Drug resistant
1-o-benzoylcastanospermine - Drug resistant
7-pentanoyltaxol - Drug resistant
7-propanoyltaxol - Drug resistant
hymenialdisine - Drug resistant
(Z)-3-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive
(Z)-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)-5-methoxyindolin-2-one - Drug sensitive
1,2-benzo-8-(d,l-alanyl)-3-phenoxazone nitrate salt - Drug sensitive
1,4-naphthoquinone, 2-chloro-3-furfurylamino- - Drug sensitive
N-(benzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine-5-carboxamide - Drug sensitive
naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive
naphthalene-1,2-dione, 1,2-dihydro-4-[(3-pyridinyl)amino]- - Drug sensitive
2-oxo-N-(pyridin-4-yl)-2-(1-tosyl-1H-indol-3-yl)acetamide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-132-3p
10-Hydroxycamptothecin 97226 Drug interaction    RC00002708
Gemcitabine 60750 Drug interaction    RC00002707
Progesterone 5994 Drug interaction    RC00002702
Estradiol 5757 Drug interaction    RC00002701
Temozolomide 5394 Drug interaction    RC00002700
Vorinostat 5311 Drug interaction    RC00002699
Imatinib 5291 Drug interaction    RC00002698
Morphine 5288826 Drug interaction    RC00002710
Paroxetine 43815 Drug interaction    RC00002706
Ifosfamide 3690 Drug interaction    RC00002697
Paclitaxel 36314 Drug interaction    RC00002705
5-Fluorouracil 3385 Drug interaction    RC00002696
Doxorubicin 31703 Drug interaction    RC00002704
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002695
Verapamil 2520 Drug interaction    RC00002694
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00002711
Arsenic trioxide 14888 Drug interaction    RC00002703
Gefitinib 123631 Drug interaction    RC00002709
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00002712
5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00002713
Chemotherapy - Drug interaction    RC00008843

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-132-3p
Interactor2: DCBLD2

Evidence Support:


Weak-Evidence Microarray
Prediction-Evidence miRWalk//Targetscan
Support Database ViRBase

References:


PMID 22822053 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line A549 cells//BEAS-2B cells//Vero cells Interactor2 expression Downregulation
Description Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems.

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