Basic Information:

  VIRBase ID:  

HHID00092622

  Virus:  

Influenza A virus (A/WSN/1933(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-187-3p:  MIMAT0000262          TLCD5:  NM_001198674     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-187-3p	TLCD5
miRBase Accession/Entrez ID	MIMAT0000262	219902
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	TMEM136

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-187-3p	rs1215538134 chr18:35904835    C/A rs1367272804 chr18:35904839    C/T rs1376568875 chr18:35904841    G/A rs372062575 chr18:35904838    G/A rs372062575 chr18:35904838    G/T rs759600111 chr18:35904836    C/T rs769745913 chr18:35904837    G/A rs1034938851 chr18:35904855    G/A rs775590170 chr18:35904854    C/T rs969703243 chr18:35904849    A/G

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-187-3p	Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293)     22984580
	TLCD5	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-187-3p
Interactor2: TLCD5

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRWalk//Targetscan
Support Database	ViRBase

References:

PMID	22822053	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	A549 cells//BEAS-2B cells//Vero cells	Interactor2 expression	Downregulation
Description	Gene expression profiling identified 26 cellular mRNAs targeted by these miRNAs, including IRAK1, MAPK3, and other components of innate immune signaling systems.