Basic Information:

  VIRBase ID:  

HHID00092581

  Virus:  

Influenza A virus (A/swine/Guangxi/3861/2011(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4763-3p:  MIMAT0019913          TLR3:  NM_003265     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4763-3p	TLR3
miRBase Accession/Entrez ID	MIMAT0019913	7098
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD283//IIAE2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4763-3p	rs111509618 chr22:46113644    C/CG rs1293184635 chr22:46113643    G/A rs1293184635 chr22:46113643    G/T rs1480117916 chr22:46113632    G/T rs574975013 chr22:46113636    G/A rs748191060 chr22:46113644    C/G rs748191060 chr22:46113644    C/T rs768794912 chr22:46113637    T/G rs781389774 chr22:46113639    C/T rs909576682 chr22:46113642    G/A rs927719598 chr22:46113645    G/A rs927719598 chr22:46113645    G/C rs927719598 chr22:46113645    G/T rs1193544941 chr22:46113631    G/A rs1216027531 chr22:46113627    C/T rs1339640536 chr22:46113626    G/C rs1483337396 chr22:46113624    AGGCAGG/A rs967155183 chr22:46113630    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TLR3	chr4:187001863(+) A-I      intronic chr4:187003336(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TLR3	chr4:186990367-186990368(+) m6A 5'UTR       24981863 chr4:186997778-186997779(+) m6A CDS       24981863 chr4:187003525-187003526(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003579-187003580(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003649-187003650(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003659-187003660(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003978-187003979(+) m6A CDS//exon       24981863 chr4:187004022-187004023(+) m6A CDS//exon       24284625//24981863 chr4:187004037-187004038(+) m6A CDS//exon       24284625//24981863 chr4:187004177-187004178(+) m6A CDS//exon       24209618//24981863 chr4:187004260-187004261(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004635-187004636(+) m6A CDS//exon       24981863 chr4:187004686-187004687(+) m6A CDS//exon       24981863 chr4:187004746-187004747(+) m6A CDS//exon       24981863 chr4:187004829-187004830(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004906-187004907(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004932-187004933(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004948-187004949(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187005082-187005083(+) m6A CDS//exon       24284625//24981863 chr4:187005090-187005091(+) m6A CDS//exon       24284625//24981863 chr4:187005095-187005096(+) m6A CDS//exon       24284625//24981863 chr4:187005155-187005156(+) m6A CDS//exon       24284625//24981863 chr4:187005181-187005182(+) m6A CDS//exon       24284625//25456834//24981863 chr4:187005214-187005215(+) m6A CDS//exon       25456834//24981863 chr4:187005236-187005237(+) m6A CDS//exon       25456834//24981863 chr4:187005310-187005311(+) m6A CDS//exon       24981863 chr4:187005888-187005889(+) m6A CDS//exon       24981863 chr4:187005893-187005894(+) m6A CDS//exon       24981863 chr4:187005944-187005945(+) m6A CDS//exon       24981863 chr4:187006013-187006014(+) m6A CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4763-3p	Exosome Pooled sera     27278097 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	TLR3	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-4763-3p	Vincristine 5978 Drug interaction    RC00008583 5-Fluorouracil 3385 Drug interaction    RC00008582 Doxorubicin 31703 Drug interaction    RC00008584 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00008581

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-4763-3p	5-Fluorouracil 3385       23525256

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4763-3p
Interactor2: TLR3

Evidence Support:

Weak-Evidence	MiRNA microarray//RNA-Seq
Prediction-Evidence	microRNA.org//PITA//Targetscan
Support Database	ViRBase

References:

PMID	30605755	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	A549 cells	Interactor2 expression	Upregulation
Description	B. Relationships between miRNAs and inversely correlated mRNAs involved in the host defense to virus. Green and red represent downregulated and upregulated genes, while triangles and circles represent miRNAs and target gene mRNAs, respectively.