Detail Information

Basic Information:


  VIRBase ID:  

HHID00092573

  Virus:  

Influenza A virus (A/swine/Guangxi/3861/2011(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4739:           UNC93B1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-4739 UNC93B1
miRBase
Accession/Entrez ID		 MIMAT0019868 81622
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IIAE1//Unc-93B1//UNC93//UNC93B

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-4739
rs1223789593 chr17:79707226    C/T
rs1279007964 chr17:79707223    C/T
rs1345189697 chr17:79707219    G/T
rs1350222948 chr17:79707231    C/A
rs1350222948 chr17:79707231    C/G
rs1350222948 chr17:79707231    C/T
rs1440530436 chr17:79707228    C/A
rs1555819261 chr17:79707222    C/T
rs73410309 chr17:79707227    G/A
rs73410309 chr17:79707227    G/C
rs73410309 chr17:79707227    G/T
rs1313792237 chr17:79707236    C/T
rs1416844919 chr17:79707238    C/T
rs1555819263 chr17:79707233    C/T
rs1555819268 chr17:79707239    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR UNC93B1
chr11:67760135(-) A-I      intronic
chr11:67769497(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase UNC93B1
chr11:67758676-67758677(-) m6A 3'UTR//exon       -
chr11:67758773-67758774(-) m6A 3'UTR//exon       -
chr11:67758813-67758814(-) m6A 3'UTR//exon       -
chr11:67758944-67758945(-) m6A 3'UTR//intron       24284625//25456834//24981863//28052920//27371828//27773536//22608085
chr11:67758996-67758997(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr11:67759052-67759053(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr11:67759079-67759080(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr11:67759176-67759177(-) m6A CDS//intron       27773536
chr11:67761248-67761249(-) Y CDS//exon//intron       26075521
chr11:67765857-67765858(-) m6A 3'UTR//CDS//exon       27773535
chr11:67765878-67765879(-) m6A 3'UTR//CDS//exon       27773535
chr11:67771318-67771319(-) m6A exon//intron       27371828//27773536
chr11:67771406-67771407(-) m6A exon//intron       27773536
chr11:67771451-67771452(-) m6A CDS//exon//intron       24981863//27371828//27773536
chr11:67771552-67771553(-) m6A 5'UTR//exon//intron       24981863
chr11:67772329-67772330(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-4739
Exosome HeLa cells     24205503
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Urine     -
UNC93B1
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-4739
Interactor2: UNC93B1

Evidence Support:


Weak-Evidence MiRNA microarray//RNA-Seq
Prediction-Evidence microRNA.org//PITA//Targetscan
Support Database ViRBase

References:


PMID 30605755 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line A549 cells Interactor2 expression Upregulation
Description B. Relationships between miRNAs and inversely correlated mRNAs involved in the host defense to virus. Green and red represent downregulated and upregulated genes, while triangles and circles represent miRNAs and target gene mRNAs, respectively.

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