Detail Information

Basic Information:


  VIRBase ID:  

HHID00092552

  Virus:  

Influenza A virus (A/swine/Guangxi/3861/2011(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4478:           SPON2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-4478 SPON2
miRBase
Accession/Entrez ID		 MIMAT0019006 10417
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DIL-1//DIL1//M-SPONDIN//MINDIN

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-4478
rs1181519808 chr9:122120163    C/T
rs955299183 chr9:122120155    C/T
rs1012836877 chr9:122120158    A/G
rs1242497537 chr9:122120157    C/G
rs985417685 chr9:122120161    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SPON2
chr4:1178532(-) A-I      intronic
chr4:1178529(-) A-I      intronic
chr4:1178479(-) A-I      intronic
chr4:1178478(-) A-I      intronic
chr4:1178466(-) A-I      intronic
chr4:1178460(-) A-I      intronic
chr4:1178052(-) A-I      intronic
chr4:1178024(-) A-I      intronic
chr4:1178011(-) A-I      intronic
chr4:1177893(-) A-I      intronic
chr4:1177872(-) A-I      intronic
chr4:1167788(-) A-I      intronic
chr4:1179420(-) A-I      intronic
chr4:1179413(-) A-I      intronic
chr4:1178597(-) A-I      intronic
chr4:1180243(-) A-I      intronic
chr4:1180240(-) A-I      intronic
chr4:1180230(-) A-I      intronic
chr4:1179037(-) A-I      intronic
chr4:1178974(-) A-I      intronic
chr4:1179433(-) A-I      intronic
chr4:1176917(-) A-I      intronic
chr4:1178938(-) A-I      intronic
chr4:1178914(-) A-I      intronic
chr4:1178991(-) A-I      intronic
chr4:1176905(-) A-I      intronic
chr4:1177974(-) A-I      intronic
chr4:1179043(-) A-I      intronic
chr4:1179057(-) A-I      intronic
chr4:1179131(-) A-I      intronic
chr4:1179332(-) A-I      intronic
chr4:1180291(-) A-I      intronic
chr4:1179333(-) A-I      intronic
chr4:1180270(-) A-I      intronic
chr4:1179374(-) A-I      intronic
chr4:1180269(-) A-I      intronic
chr4:1180266(-) A-I      intronic
chr4:1178900(-) A-I      intronic
chr4:1178698(-) A-I      intronic
chr4:1178663(-) A-I      intronic
chr4:1178643(-) A-I      intronic
chr4:1179387(-) A-I      intronic
chr4:1180260(-) A-I      intronic
chr4:1179388(-) A-I      intronic
chr4:1180256(-) A-I      intronic
chr4:1178616(-) A-I      intronic
chr4:1179372(-) A-I      intronic
chr4:1178668(-) A-I      intronic
chr4:1167918(-) A-I      intronic
chr4:1178954(-) A-I      intronic
chr4:1179059(-) A-I      intronic
chr4:1177913(-) A-I      intronic
chr4:1179136(-) A-I      intronic
chr4:1167822(-) A-I      intronic
chr4:1177868(-) A-I      intronic
chr4:1195495(-) A-I      intronic
chr4:1178488(-) A-I      intronic
chr4:1167785(-) A-I      intronic
chr4:1178541(-) A-I      intronic
chr4:1180364(-) A-I      intronic
chr4:1176946(-) A-I      intronic
chr4:1177871(-) A-I      intronic
chr4:1178538(-) A-I      intronic
chr4:1178557(-) A-I      intronic
chr4:1176837(-) A-I      intronic
chr4:1176907(-) A-I      intronic
chr4:1195555(-) A-I      intronic
chr4:1197887(-) A-I      intronic
chr4:1179330(-) A-I      intronic
chr4:1177903(-) A-I      intronic
chr4:1178554(-) A-I      intronic
chr4:1195552(-) A-I      intronic
chr4:1178996(-) A-I      intronic
chr4:1179091(-) A-I      intronic
chr4:1167732(-) A-I      intronic
chr4:1179092(-) A-I      intronic
chr4:1180229(-) A-I      intronic
chr4:1180371(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SPON2
chr4:1176907(-) A-I intron -    22327324
chr4:1176946(-) A-I intron -    22327324
chr4:1177868(-) A-I intron -    22327324
chr4:1178488(-) A-I intron -    22327324
chr4:1178541(-) A-I intron -    22327324
chr4:1178557(-) A-I intron -    22327324
chr4:1178662(-) A-I intron -    22327324
chr4:1167822(-) A-G intron -    22484847
chr4:1167918(-) A-G intron -    22484847
chr4:1168291(-) G-T intron -    22484847
chr4:1176837(-) A-G intron -    22484847
chr4:1176907(-) A-G intron -    22484847
chr4:1176908(-) T-C intron -    22484847
chr4:1176909(-) T-C intron -    22484847
chr4:1176922(-) T-C intron -    22484847
chr4:1176946(-) A-G intron -    22484847
chr4:1177028(-) G-T intron -    22484847
chr4:1177868(-) A-G intron -    22484847
chr4:1177871(-) A-G intron -    22484847
chr4:1177973(-) A-G intron -    22484847
chr4:1178541(-) A-G intron -    22484847
chr4:1178557(-) A-G intron -    22484847
chr4:1178625(-) A-G intron -    22484847
chr4:1178642(-) A-G intron -    22484847
chr4:1178954(-) A-G intron -    22484847
chr4:1179060(-) A-G intron -    22484847
chr4:1179091(-) A-G intron -    22484847
chr4:1179092(-) A-G intron -    22484847
chr4:1179106(-) A-G intron -    22484847
chr4:1179136(-) A-G intron -    22484847
chr4:1179137(-) A-G intron -    22484847
chr4:1179330(-) A-G intron -    22484847
chr4:1179339(-) A-G intron -    22484847
chr4:1179444(-) A-G intron -    22484847
chr4:1180371(-) A-G intron -    22484847
chr4:1182015(-) C-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SPON2
chr4:1160739-1160740(-) m6A 3'UTR       24284625
chr4:1160877-1160878(-) m6A 3'UTR       24284625
chr4:1161076-1161077(-) m6A 3'UTR       24284625//25456834
chr4:1161257-1161258(-) m6A 3'UTR       24284625//27371828
chr4:1161351-1161352(-) m6A CDS       24284625//25456834//27371828
chr4:1161363-1161364(-) m6A CDS       24284625//25456834//27371828
chr4:1161394-1161395(-) m6A CDS       24284625//25456834//27371828
chr4:1161425-1161426(-) m6A CDS       24284625//25456834//27371828
chr4:1163695-1163696(-) m6A exon//intron       24284625
chr4:1163910-1163911(-) m6A exon//intron       27773535//27371828
chr4:1163925-1163926(-) m6A exon//intron       27773535//27371828
chr4:1163939-1163940(-) m6A exon//intron       24284625//27773535//27371828
chr4:1164116-1164117(-) m6A exon//intron       27773535
chr4:1164122-1164123(-) m6A exon//intron       27773535
chr4:1164146-1164147(-) m6A exon//intron       24284625//27773535
chr4:1164163-1164164(-) m6A exon//intron       24284625//27773535
chr4:1164181-1164182(-) m6A exon//intron       24284625//27773535
chr4:1164200-1164201(-) m6A CDS//exon       24284625//27773535
chr4:1164215-1164216(-) m6A CDS//exon       24284625//27773535
chr4:1164799-1164800(-) m6A CDS//exon       24284625//27773535
chr4:1164847-1164848(-) m6A CDS//exon       24284625//27773535
chr4:1164874-1164875(-) m6A CDS//exon       24284625//27773535
chr4:1164888-1164889(-) m6A CDS//exon       24284625//27773535
chr4:1164901-1164902(-) m6A CDS//exon       24284625
chr4:1164916-1164917(-) m6A CDS//exon       24284625
chr4:1164925-1164926(-) m6A CDS//exon       24284625
chr4:1165234-1165235(-) m6A CDS//exon       24284625
chr4:1165525-1165526(-) m6A exon//intron       24284625
chr4:1165851-1165852(-) m6A CDS//exon       24284625
chr4:1166440-1166441(-) m6A 5'UTR//exon       -
chr4:1166449-1166450(-) m6A 5'UTR//exon       -
chr4:1166626-1166627(-) m6A 5'UTR//exon//intron       -
chr4:1166634-1166635(-) m6A 5'UTR//intron       -
chr4:1175215-1175216(-) Tm intron       -
chr4:1188791-1188792(-) m6A 5'UTR//intron       24284625
chr4:1190758-1190759(-) m6A exon//intron       24284625
chr4:1190815-1190816(-) m6A exon//intron       24284625
chr4:1190899-1190900(-) m6A exon//intron       24284625
chr4:1193749-1193750(-) m6A exon//intron       27371828
chr4:1193789-1193790(-) m6A exon//intron       27371828
chr4:1195068-1195069(-) m6A 5'UTR//exon//intron       24284625//27371828
chr4:1195081-1195082(-) m6A 5'UTR//exon//intron       24284625//27371828
chr4:1195145-1195146(-) m6A 5'UTR//exon//intron       24284625//27371828
chr4:1195186-1195187(-) m6A 5'UTR//exon//intron       24284625//27371828
chr4:1198786-1198787(-) m6A 5'UTR//exon//intron       24284625//27371828
chr4:1198795-1198796(-) m6A 5'UTR//exon//intron       24284625//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-4478
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
SPON2
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-4478
Interactor2: SPON2

Evidence Support:


Weak-Evidence MiRNA microarray//RNA-Seq
Prediction-Evidence microRNA.org//PITA//Targetscan
Support Database ViRBase

References:


PMID 30605755 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line A549 cells Interactor2 expression Downregulation
Description B. Relationships between miRNAs and inversely correlated mRNAs involved in the host defense to virus. Green and red represent downregulated and upregulated genes, while triangles and circles represent miRNAs and target gene mRNAs, respectively.

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