Basic Information:

  VIRBase ID:  

HHID00092535

  Virus:  

Influenza A virus (A/swine/Guangxi/3861/2011(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4281:  MIMAT0016907          CASP10:  NM_001230     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4281	CASP10
miRBase Accession/Entrez ID	MIMAT0016907	843
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ALPS2//FLICE-2//FLICE2//MCH4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4281	rs746495416 chr5:176629453    C/G rs746495416 chr5:176629453    C/T rs759166911 chr5:176629455    TC/T rs768735686 chr5:176629454    C/G rs779751131 chr5:176629449    C/A rs779751131 chr5:176629449    C/T rs921488943 chr5:176629466    C/T rs1040286402 chr5:176629464    C/T rs1375541904 chr5:176629459    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CASP10	chr2:202077289(+) A-I      intronic chr2:202077308(+) A-I      intronic chr2:202077298(+) A-I      intronic chr2:202077283(+) A-I      intronic chr2:202077280(+) A-I      intronic chr2:202077274(+) A-I      intronic chr2:202083746(+) A-I      3'UTR chr2:202083768(+) A-I      3'UTR chr2:202083778(+) A-I      3'UTR chr2:202083897(+) A-I      3'UTR chr2:202083902(+) A-I      3'UTR chr2:202083973(+) A-I      3'UTR chr2:202063926(+) A-I      intronic chr2:202092825(+) A-I      intronic chr2:202092844(+) A-I      intronic chr2:202080994(+) A-I      intronic chr2:202092797(+) A-I      intronic chr2:202053650(+) A-I      intronic chr2:202077322(+) A-I      intronic chr2:202053797(+) A-I      intronic chr2:202092830(+) A-I      intronic chr2:202092839(+) A-I      intronic chr2:202082763(+) A-I      3'UTR chr2:202092855(+) A-I      intronic chr2:202077259(+) A-I      intronic chr2:202077264(+) A-I      intronic chr2:202077265(+) A-I      intronic chr2:202083125(+) A-I      3'UTR chr2:202077268(+) A-I      intronic chr2:202092858(+) A-I      intronic chr2:202064495(+) A-I      intronic chr2:202083287(+) A-I      3'UTR chr2:202083743(+) A-I      3'UTR chr2:202054144(+) A-I      intronic chr2:202053015(+) A-I      intronic chr2:202053711(+) A-I      intronic chr2:202053829(+) A-I      intronic chr2:202053838(+) A-I      intronic chr2:202053855(+) A-I      intronic chr2:202053856(+) A-I      intronic chr2:202053857(+) A-I      intronic chr2:202053887(+) A-I      intronic chr2:202054157(+) A-I      intronic chr2:202054166(+) A-I      intronic chr2:202054488(+) A-I      intronic chr2:202054512(+) A-I      intronic chr2:202054559(+) A-I      intronic chr2:202057010(+) A-I      intronic chr2:202057006(+) A-I      intronic chr2:202056863(+) A-I      intronic chr2:202056854(+) A-I      intronic chr2:202054575(+) A-I      intronic chr2:202092899(+) A-I      intronic chr2:202092834(+) A-I      intronic chr2:202092826(+) A-I      intronic chr2:202092513(+) A-I      intronic chr2:202092489(+) A-I      intronic chr2:202092397(+) A-I      intronic chr2:202092379(+) A-I      intronic chr2:202087079(+) A-I      intronic chr2:202087069(+) A-I      intronic chr2:202080604(+) A-I      intronic chr2:202076801(+) A-I      intronic chr2:202064119(+) A-I      intronic chr2:202082239(+) A-I      intronic chr2:202082237(+) A-I      intronic chr2:202082207(+) A-I      intronic chr2:202082171(+) A-I      intronic chr2:202080949(+) A-I      intronic chr2:202080605(+) A-I      intronic chr2:202073621(+) A-I      intronic chr2:202073559(+) A-I      intronic chr2:202073501(+) A-I      intronic chr2:202072134(+) A-I      intronic chr2:202071423(+) A-I      intronic chr2:202065874(+) A-I      intronic chr2:202064439(+) A-I      intronic chr2:202064432(+) A-I      intronic chr2:202064423(+) A-I      intronic chr2:202064391(+) A-I      intronic chr2:202064378(+) A-I      intronic chr2:202062250(+) A-I      intronic chr2:202062128(+) A-I      intronic chr2:202054561(+) A-I      intronic chr2:202061938(+) A-I      intronic chr2:202062247(+) A-I      intronic chr2:202083277(+) A-I      3'UTR chr2:202083913(+) A-I      3'UTR chr2:202083264(+) A-I      3'UTR chr2:202083138(+) A-I      3'UTR chr2:202083764(+) A-I      3'UTR chr2:202083759(+) A-I      3'UTR chr2:202083904(+) A-I      3'UTR chr2:202083958(+) A-I      3'UTR chr2:202082711(+) A-I      3'UTR chr2:202082867(+) A-I      3'UTR chr2:202083729(+) A-I      3'UTR chr2:202083817(+) A-I      3'UTR chr2:202083272(+) A-I      3'UTR chr2:202083792(+) A-I      3'UTR chr2:202083725(+) A-I      3'UTR chr2:202082907(+) A-I      3'UTR chr2:202083143(+) A-I      3'UTR chr2:202082866(+) A-I      3'UTR chr2:202083878(+) A-I      3'UTR chr2:202083942(+) A-I      3'UTR chr2:202083943(+) A-I      3'UTR chr2:202061883(+) A-I      intronic chr2:202091219(+) A-I      intronic chr2:202056956(+) A-I      intronic chr2:202080553(+) A-I      intronic chr2:202092898(+) A-I      intronic chr2:202087020(+) A-I      intronic chr2:202054652(+) A-I      intronic chr2:202081062(+) A-I      intronic chr2:202092979(+) A-I      intronic chr2:202086988(+) A-I      intronic chr2:202057059(+) A-I      intronic chr2:202062118(+) A-I      intronic chr2:202064112(+) A-I      intronic chr2:202064375(+) A-I      intronic chr2:202081011(+) A-I      intronic chr2:202082701(+) A-I      3'UTR chr2:202082723(+) A-I      3'UTR chr2:202082754(+) A-I      3'UTR chr2:202083093(+) A-I      3'UTR chr2:202082905(+) A-I      3'UTR chr2:202083895(+) A-I      3'UTR chr2:202082730(+) A-I      3'UTR chr2:202083286(+) A-I      3'UTR chr2:202083873(+) A-I      3'UTR chr2:202083872(+) A-I      3'UTR chr2:202083905(+) A-I      3'UTR chr2:202083975(+) A-I      3'UTR chr2:202083235(+) A-I      3'UTR chr2:202083126(+) A-I      3'UTR chr2:202083972(+) A-I      3'UTR chr2:202083197(+) A-I      3'UTR chr2:202083773(+) A-I      3'UTR chr2:202082704(+) A-I      3'UTR chr2:202082737(+) A-I      3'UTR chr2:202082762(+) A-I      3'UTR chr2:202083260(+) A-I      3'UTR chr2:202082776(+) A-I      3'UTR chr2:202083882(+) A-I      3'UTR chr2:202083914(+) A-I      3'UTR chr2:202083755(+) A-I      3'UTR chr2:202083925(+) A-I      3'UTR chr2:202082865(+) A-I      3'UTR chr2:202082662(+) A-I      3'UTR chr2:202064498(+) A-I      intronic chr2:202087162(+) A-I      intronic chr2:202071420(+) A-I      intronic chr2:202054560(+) A-I      intronic chr2:202092938(+) A-I      intronic chr2:202092795(+) A-I      intronic chr2:202061974(+) A-I      intronic chr2:202092820(+) A-I      intronic chr2:202054642(+) A-I      intronic chr2:202054601(+) A-I      intronic chr2:202054649(+) A-I      intronic chr2:202080971(+) A-I      intronic chr2:202071413(+) A-I      intronic chr2:202061889(+) A-I      intronic chr2:202072227(+) A-I      intronic chr2:202064415(+) A-I      intronic chr2:202054072(+) A-I      intronic chr2:202061920(+) A-I      intronic chr2:202054091(+) A-I      intronic chr2:202066014(+) A-I      intronic chr2:202072143(+) A-I      intronic chr2:202061890(+) A-I      intronic chr2:202062283(+) A-I      intronic chr2:202080995(+) A-I      intronic chr2:202053674(+) A-I      intronic chr2:202064559(+) A-I      intronic chr2:202092785(+) A-I      intronic chr2:202053624(+) A-I      intronic chr2:202064549(+) A-I      intronic chr2:202080977(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CASP10	chr2:202082668(+) A-I exon 3'UTR    15342557   //22327324 chr2:202083057(+) A-I exon 3'UTR    15342557 chr2:202083152(+) A-I exon 3'UTR    15342557 chr2:202083197(+) A-I exon 3'UTR    15342557 chr2:202083755(+) A-I exon 3'UTR    15342557 chr2:202083773(+) A-I exon 3'UTR    15342557 chr2:202083872(+) A-I exon 3'UTR    15342557   //22327324 chr2:202083905(+) A-I exon 3'UTR    15342557 chr2:202082730(+) A-I intron -    22327324 chr2:202083918(+) A-I intron -    22327324 chr2:202083057(+) A-G intron -    21725310   //22484847 chr2:202086083(+) T-C intron -    21725310 chr2:202054601(+) A-G intron -    22484847 chr2:202055641(+) A-G intron -    22484847 chr2:202061920(+) A-G intron -    22484847 chr2:202061974(+) A-G intron -    22484847 chr2:202062118(+) A-G intron -    22484847 chr2:202064549(+) A-G intron -    22484847 chr2:202071413(+) A-G intron -    22484847 chr2:202072143(+) A-G intron -    22484847 chr2:202072279(+) A-G intron -    22484847 chr2:202082668(+) A-G intron -    22484847 chr2:202082730(+) A-G intron -    22484847 chr2:202082762(+) A-G intron -    22484847 chr2:202083245(+) A-G intron -    22484847 chr2:202083872(+) A-G intron -    22484847 chr2:202083873(+) A-G intron -    22484847 chr2:202083899(+) A-G intron -    22484847 chr2:202083918(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CASP10	chr2:202047831-202047832(+) m6A 5'UTR       24981863 chr2:202047876-202047877(+) m6A 5'UTR//exon       24981863 chr2:202047927-202047928(+) m6A 5'UTR//exon       24981863 chr2:202047963-202047964(+) m6A 5'UTR//exon       24981863 chr2:202047991-202047992(+) m6A 5'UTR//exon       24981863 chr2:202073915-202073916(+) m6A 3'UTR//CDS//exon       - chr2:202074033-202074034(+) m6A 3'UTR//CDS//exon       25456834//24981863 chr2:202074045-202074046(+) m6A 3'UTR//CDS//exon       25456834//24981863 chr2:202074051-202074052(+) m6A 3'UTR//CDS//exon       25456834 chr2:202074122-202074123(+) m6A 3'UTR//CDS//exon       25456834//24981863 chr2:202074152-202074153(+) m6A 3'UTR//CDS//exon       25456834 chr2:202082380-202082381(+) m6A 3'UTR//CDS//exon//intron       24981863 chr2:202082388-202082389(+) m6A 3'UTR//CDS//exon//intron       24981863 chr2:202082424-202082425(+) m6A 3'UTR//CDS//exon//intron       24981863 chr2:202083711-202083712(+) m6A 3'UTR//intron       25456834//24981863 chr2:202083793-202083794(+) m6A 3'UTR//intron       25456834//24981863 chr2:202083816-202083817(+) m6A 3'UTR//intron       25456834//24981863 chr2:202083834-202083835(+) m6A 3'UTR//intron       25456834//24981863 chr2:202083982-202083983(+) m6A 3'UTR//intron       22608085 chr2:202084019-202084020(+) m6A 3'UTR//intron       22608085 chr2:202084042-202084043(+) m6A 3'UTR//intron       24981863//22608085 chr2:202084101-202084102(+) m6A 3'UTR//intron       25456834//24981863//22608085 chr2:202084146-202084147(+) m6A 3'UTR//intron       25456834//24981863//22608085 chr2:202084210-202084211(+) m6A 3'UTR//intron       25456834//24981863//22608085 chr2:202084220-202084221(+) m6A 3'UTR//intron       25456834//24981863//22608085 chr2:202084295-202084296(+) m6A 3'UTR//intron       24209618//25456834//24981863//22608085 chr2:202084460-202084461(+) m6A 3'UTR//intron       24209618//24981863//22608085 chr2:202084484-202084485(+) m6A 3'UTR//intron       24981863//22608085 chr2:202084587-202084588(+) m6A 3'UTR//intron       24981863//22608085 chr2:202084636-202084637(+) m6A 3'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4281	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	CASP10	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4281
Interactor2: CASP10

Evidence Support:

Weak-Evidence	MiRNA microarray//RNA-Seq
Prediction-Evidence	microRNA.org//PITA//Targetscan
Support Database	ViRBase

References:

PMID	30605755	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	A549 cells	Interactor2 expression	Upregulation
Description	A. Relationships between miRNAs and inversely correlated mRNAs involved in the influenza A pathway.