Detail Information

Basic Information:


  VIRBase ID:  

HHID00092518

  Virus:  

Influenza A virus (A/swine/Guangxi/3861/2011(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1915-3p:           TRIM5:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1915-3p TRIM5
miRBase
Accession/Entrez ID		 MIMAT0007892 85363
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - RNF88//TRIM5alpha

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1915-3p
rs1319660164 chr10:21496576    C/T
rs1335396985 chr10:21496581    C/G
rs1359100620 chr10:21496582    G/A
rs1416262346 chr10:21496578    C/A
rs540277336 chr10:21496579    G/A
rs540277336 chr10:21496579    G/C
rs983068182 chr10:21496591    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TRIM5
chr11:5689458(-) A-I      intronic
chr11:5685228(-) A-I      3'UTR
chr11:5685269(-) A-I      3'UTR
chr11:5685188(-) A-I      3'UTR
chr11:5685220(-) A-I      3'UTR
chr11:5689385(-) A-I      intronic
chr11:5685173(-) A-I      3'UTR
chr11:5685166(-) A-I      3'UTR
chr11:5689417(-) A-I      intronic
chr11:5689448(-) A-I      intronic
chr11:5685362(-) A-I      NonSyn:Thr->Ala
chr11:5685348(-) A-I      Syn:Gln->Gln
chr11:5685368(-) A-I      NonSyn:Thr->Ala
chr11:5685387(-) A-I      Syn:Ala->Ala
chr11:5685344(-) A-I      NonSyn:Ile->Val
chr11:5685331(-) A-I      NonSyn:Gln->Arg
chr11:5685319(-) A-I      NonSyn:Stp->Trp
chr11:5688522(-) A-I      intronic
chr11:5688513(-) A-I      intronic
chr11:5688505(-) A-I      intronic
chr11:5688499(-) A-I      intronic
chr11:5691062(-) A-I      intronic
chr11:5688470(-) A-I      intronic
chr11:5691536(-) A-I      intronic
chr11:5688548(-) A-I      intronic
chr11:5692273(-) A-I      intronic
chr11:5688504(-) A-I      intronic
chr11:5689737(-) A-I      intronic
chr11:5689812(-) A-I      intronic
chr11:5689821(-) A-I      intronic
chr11:5689849(-) A-I      intronic
chr11:5689862(-) A-I      intronic
chr11:5689883(-) A-I      intronic
chr11:5689899(-) A-I      intronic
chr11:5689917(-) A-I      intronic
chr11:5690406(-) A-I      intronic
chr11:5690421(-) A-I      intronic
chr11:5690425(-) A-I      intronic
chr11:5690431(-) A-I      intronic
chr11:5690434(-) A-I      intronic
chr11:5690447(-) A-I      intronic
chr11:5690448(-) A-I      intronic
chr11:5690965(-) A-I      intronic
chr11:5690998(-) A-I      intronic
chr11:5693714(-) A-I      intronic
chr11:5691011(-) A-I      intronic
chr11:5691053(-) A-I      intronic
chr11:5691142(-) A-I      intronic
chr11:5691620(-) A-I      intronic
chr11:5689395(-) A-I      intronic
chr11:5691455(-) A-I      intronic
chr11:5703286(-) A-I      intronic
chr11:5692276(-) A-I      intronic
chr11:5692217(-) A-I      intronic
chr11:5698834(-) A-I      intronic
chr11:5703494(-) A-I      intronic
chr11:5703377(-) A-I      intronic
chr11:5692369(-) A-I      intronic
chr11:5689874(-) A-I      intronic
chr11:5703459(-) A-I      intronic
chr11:5692344(-) A-I      intronic
chr11:5688612(-) A-I      intronic
chr11:5703495(-) A-I      intronic
chr11:5703521(-) A-I      intronic
chr11:5691158(-) A-I      intronic
chr11:5689952(-) A-I      intronic
chr11:5689386(-) A-I      intronic
chr11:5691519(-) A-I      intronic
chr11:5691521(-) A-I      intronic
chr11:5693654(-) A-I      intronic
chr11:5690416(-) A-I      intronic
chr11:5691522(-) A-I      intronic
chr11:5691036(-) A-I      intronic
chr11:5689505(-) A-I      intronic
chr11:5692356(-) A-I      intronic
chr11:5688601(-) A-I      intronic
chr11:5693518(-) A-I      intronic
chr11:5692281(-) A-I      intronic
chr11:5693520(-) A-I      intronic
chr11:5692450(-) A-I      intronic
chr11:5692334(-) A-I      intronic
chr11:5696327(-) A-I      intronic
chr11:5689467(-) A-I      intronic
chr11:5691580(-) A-I      intronic
chr11:5696331(-) A-I      intronic
chr11:5689881(-) A-I      intronic
chr11:5693708(-) A-I      intronic
chr11:5689419(-) A-I      intronic
chr11:5688635(-) A-I      intronic
chr11:5689791(-) A-I      intronic
chr11:5689776(-) A-I      intronic
chr11:5690528(-) A-I      intronic
chr11:5692229(-) A-I      intronic
chr11:5693645(-) A-I      intronic
chr11:5691119(-) A-I      intronic
chr11:5693618(-) A-I      intronic
chr11:5696319(-) A-I      intronic
chr11:5693553(-) A-I      intronic
chr11:5688702(-) A-I      intronic
chr11:5692425(-) A-I      intronic
chr11:5688558(-) A-I      intronic
chr11:5693580(-) A-I      intronic
chr11:5693606(-) A-I      intronic
chr11:5691513(-) A-I      intronic
chr11:5691514(-) A-I      intronic
chr11:5692239(-) A-I      intronic
chr11:5685266(-) A-I      3'UTR
chr11:5685309(-) A-I      3'UTR
chr11:5685230(-) A-I      3'UTR
chr11:5685282(-) A-I      3'UTR
chr11:5685430(-) A-I      3'UTR
chr11:5685240(-) A-I      3'UTR
chr11:5685355(-) A-I      NonSyn:Gln->Arg
chr11:5685323(-) A-I      NonSyn:Lys->Glu
chr11:5685392(-) A-I      NonSyn:Met->Val
chr11:5693590(-) A-I      intronic
chr11:5689953(-) A-I      intronic
chr11:5688575(-) A-I      intronic
chr11:5691610(-) A-I      intronic
chr11:5692253(-) A-I      intronic
chr11:5703193(-) A-I      intronic
chr11:5689396(-) A-I      intronic
chr11:5689453(-) A-I      intronic
chr11:5691123(-) A-I      intronic
chr11:5692307(-) A-I      intronic
chr11:5689930(-) A-I      intronic
chr11:5691060(-) A-I      intronic
chr11:5691043(-) A-I      intronic
chr11:5696433(-) A-I      intronic
chr11:5692373(-) A-I      intronic
chr11:5703390(-) A-I      intronic
chr11:5692324(-) A-I      intronic
chr11:5692454(-) A-I      intronic
chr11:5703383(-) A-I      intronic
chr11:5691198(-) A-I      intronic
chr11:5691048(-) A-I      intronic
chr11:5692290(-) A-I      intronic
chr11:5693579(-) A-I      intronic
chr11:5692308(-) A-I      intronic
chr11:5689898(-) A-I      intronic
chr11:5691121(-) A-I      intronic
chr11:5689808(-) A-I      intronic
chr11:5691096(-) A-I      intronic
chr11:5703462(-) A-I      intronic
chr11:5688574(-) A-I      intronic
chr11:5689464(-) A-I      intronic
chr11:5698940(-) A-I      intronic
chr11:5693615(-) A-I      intronic
chr11:5692396(-) A-I      intronic
chr11:5688471(-) A-I      intronic
chr11:5693713(-) A-I      intronic
chr11:5689844(-) A-I      intronic
chr11:5688616(-) A-I      intronic
chr11:5703471(-) A-I      intronic
chr11:5698931(-) A-I      intronic
chr11:5692370(-) A-I      intronic
chr11:5691148(-) A-I      intronic
chr11:5688494(-) A-I      intronic
chr11:5691546(-) A-I      intronic
chr11:5691143(-) A-I      intronic
chr11:5691122(-) A-I      intronic
chr11:5691023(-) A-I      intronic
chr11:5692361(-) A-I      intronic
chr11:5688569(-) A-I      intronic
chr11:5703223(-) A-I      intronic
chr11:5689380(-) A-I      intronic
chr11:5698932(-) A-I      intronic
chr11:5691093(-) A-I      intronic
chr11:5689382(-) A-I      intronic
chr11:5689859(-) A-I      intronic
chr11:5691105(-) A-I      intronic
chr11:5691572(-) A-I      intronic
chr11:5689817(-) A-I      intronic
chr11:5689409(-) A-I      intronic
chr11:5703161(-) A-I      intronic
chr11:5691671(-) A-I      intronic
chr11:5693565(-) A-I      intronic
chr11:5693539(-) A-I      intronic
chr11:5692394(-) A-I      intronic
chr11:5688565(-) A-I      intronic
chr11:5689718(-) A-I      intronic
chr11:5690971(-) A-I      intronic
chr11:5690993(-) A-I      intronic
chr11:5692288(-) A-I      intronic
chr11:5688704(-) A-I      intronic
chr11:5703386(-) A-I      intronic
chr11:5693611(-) A-I      intronic
chr11:5689491(-) A-I      intronic
chr11:5690969(-) A-I      intronic
chr11:5689392(-) A-I      intronic
chr11:5689756(-) A-I      intronic
chr11:5693624(-) A-I      intronic
chr11:5692442(-) A-I      intronic
chr11:5692387(-) A-I      intronic
chr11:5698810(-) A-I      intronic
chr11:5691480(-) A-I      intronic
chr11:5703041(-) A-I      intronic
chr11:5689873(-) A-I      intronic
chr11:5689818(-) A-I      intronic
chr11:5693609(-) A-I      intronic
chr11:5691672(-) A-I      intronic
chr11:5689331(-) A-I      intronic
chr11:5703451(-) A-I      intronic
chr11:5692299(-) A-I      intronic
chr11:5690582(-) A-I      intronic
chr11:5688615(-) A-I      intronic
chr11:5690415(-) A-I      intronic
chr11:5691010(-) A-I      intronic
chr11:5688472(-) A-I      intronic
chr11:5690583(-) A-I      intronic
chr11:5689931(-) A-I      intronic
chr11:5691118(-) A-I      intronic
chr11:5689418(-) A-I      intronic
chr11:5685187(-) A-I      3'UTR
chr11:5685175(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TRIM5
chr11:5689382(-) A-I intron -    22327324
chr11:5689464(-) A-I intron -    22327324
chr11:5689818(-) A-I intron -    22327324
chr11:5689953(-) A-I intron -    22327324
chr11:5691105(-) A-I intron -    22327324
chr11:5691122(-) A-I intron -    22327324
chr11:5691672(-) A-I intron -    22327324
chr11:5692334(-) A-I intron -    22327324
chr11:5692394(-) A-I intron -    22327324
chr11:5693606(-) A-I intron -    22327324
chr11:5693713(-) A-I intron -    22327324
chr11:5692273(-) A-I intron -    21960545
chr11:5688504(-) A-G intron -    22484847
chr11:5689331(-) A-G intron -    22484847
chr11:5689382(-) A-G intron -    22484847
chr11:5689392(-) A-G intron -    22484847
chr11:5689396(-) A-G intron -    22484847
chr11:5689419(-) A-G intron -    22484847
chr11:5689453(-) A-G intron -    22484847
chr11:5689464(-) A-G intron -    22484847
chr11:5689791(-) A-G intron -    22484847
chr11:5689808(-) A-G intron -    22484847
chr11:5689817(-) A-G intron -    22484847
chr11:5689818(-) A-G intron -    22484847
chr11:5689881(-) A-G intron -    22484847
chr11:5689931(-) A-G intron -    22484847
chr11:5689953(-) A-G intron -    22484847
chr11:5690415(-) A-G intron -    22484847
chr11:5690416(-) A-G intron -    22484847
chr11:5690583(-) A-G intron -    22484847
chr11:5691105(-) A-G intron -    22484847
chr11:5691121(-) A-G intron -    22484847
chr11:5691122(-) A-G intron -    22484847
chr11:5691123(-) A-G intron -    22484847
chr11:5691480(-) A-G intron -    22484847
chr11:5691513(-) A-G intron -    22484847
chr11:5691672(-) A-G intron -    22484847
chr11:5692273(-) A-G intron -    22484847
chr11:5692290(-) A-G intron -    22484847
chr11:5692334(-) A-G intron -    22484847
chr11:5692370(-) A-G intron -    22484847
chr11:5692394(-) A-G intron -    22484847
chr11:5692425(-) A-G intron -    22484847
chr11:5693606(-) A-G intron -    22484847
chr11:5693713(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TRIM5
chr11:5684846-5684847(-) m6A 3'UTR       27773535
chr11:5684853-5684854(-) m6A 3'UTR       27773535
chr11:5684914-5684915(-) m6A 3'UTR       27773535
chr11:5685777-5685778(-) m6A 3'UTR//intron       27773535
chr11:5685802-5685803(-) m6A 3'UTR//intron       27773535
chr11:5685972-5685973(-) m6A 3'UTR//intron       27773535
chr11:5686037-5686038(-) m6A 3'UTR//intron       27773535
chr11:5686153-5686154(-) m6A 3'UTR//CDS//intron       27773535
chr11:5686192-5686193(-) m6A 3'UTR//CDS//intron       27773535
chr11:5686415-5686416(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr11:5686446-5686447(-) m6A 3'UTR//CDS//exon//intron       24981863//26404942//27773535
chr11:5686508-5686509(-) m6A 3'UTR//CDS//exon//intron       24981863//26404942//27773535
chr11:5686520-5686521(-) m6A 3'UTR//CDS//exon//intron       24981863//26404942//27773535
chr11:5686548-5686549(-) m6A 3'UTR//CDS//exon//intron       24981863//26404942//27773535
chr11:5686566-5686567(-) m6A 3'UTR//CDS//exon//intron       24981863//26404942//27773535
chr11:5686603-5686604(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr11:5687279-5687280(-) m6A CDS//exon//intron       27773535
chr11:5699326-5699327(-) m6A exon//intron       -
chr11:5699504-5699505(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27371828//22608085
chr11:5699522-5699523(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27371828//22608085
chr11:5699530-5699531(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27371828//22608085
chr11:5699551-5699552(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22608085
chr11:5699572-5699573(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr11:5699599-5699600(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr11:5699608-5699609(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr11:5699642-5699643(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr11:5701104-5701105(-) m6A CDS//exon       27773535
chr11:5701210-5701211(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828
chr11:5701261-5701262(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr11:5701282-5701283(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr11:5701321-5701322(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr11:5701347-5701348(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr11:5701433-5701434(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27371828
chr11:5701448-5701449(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27371828
chr11:5701457-5701458(-) m6A 5'UTR       24284625//24209618//27371828
chr11:5705223-5705224(-) m6A 5'UTR//intron       24284625//24209618//27371828
chr11:5706111-5706112(-) m6A 5'UTR//intron       24981863//27773535
chr11:5706116-5706117(-) m6A 5'UTR//intron       24981863//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1915-3p
Exosome Pooled sera     27278097
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
TRIM5
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1915-3p
Interactor2: TRIM5

Evidence Support:


Weak-Evidence MiRNA microarray//RNA-Seq
Prediction-Evidence microRNA.org//PITA//Targetscan
Support Database ViRBase

References:


PMID 30605755 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line A549 cells Interactor2 expression Upregulation
Description B. Relationships between miRNAs and inversely correlated mRNAs involved in the host defense to virus. Green and red represent downregulated and upregulated genes, while triangles and circles represent miRNAs and target gene mRNAs, respectively.

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