Basic Information:

  VIRBase ID:  

HHID00092515

  Virus:  

Influenza A virus (A/swine/Guangxi/3861/2011(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1915-3p:  MIMAT0007892          ZC3HAV1:  NM_001363491     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1915-3p	ZC3HAV1
miRBase Accession/Entrez ID	MIMAT0007892	56829
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARTD13//FLB6421//PARP13//ZAP//ZC3H2//ZC3HDC2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1915-3p	rs1319660164 chr10:21496576    C/T rs1335396985 chr10:21496581    C/G rs1359100620 chr10:21496582    G/A rs1416262346 chr10:21496578    C/A rs540277336 chr10:21496579    G/A rs540277336 chr10:21496579    G/C rs983068182 chr10:21496591    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZC3HAV1	chr7:138750501(-) A-I      intronic chr7:138737160(-) A-I      intronic chr7:138750467(-) A-I      intronic chr7:138750470(-) A-I      intronic chr7:138737186(-) A-I      intronic chr7:138752124(-) A-I      intronic chr7:138752143(-) A-I      intronic chr7:138752148(-) A-I      intronic chr7:138752866(-) A-I      intronic chr7:138752868(-) A-I      intronic chr7:138752974(-) A-I      intronic chr7:138752999(-) A-I      intronic chr7:138753079(-) A-I      intronic chr7:138755604(-) A-I      intronic chr7:138755697(-) A-I      intronic chr7:138755940(-) A-I      intronic chr7:138755950(-) A-I      intronic chr7:138756065(-) A-I      intronic chr7:138756124(-) A-I      intronic chr7:138757008(-) A-I      intronic chr7:138757105(-) A-I      intronic chr7:138757107(-) A-I      intronic chr7:138757108(-) A-I      intronic chr7:138757109(-) A-I      intronic chr7:138757114(-) A-I      intronic chr7:138757812(-) A-I      intronic chr7:138757894(-) A-I      intronic chr7:138757898(-) A-I      intronic chr7:138757921(-) A-I      intronic chr7:138758026(-) A-I      intronic chr7:138758414(-) A-I      intronic chr7:138758415(-) A-I      intronic chr7:138758483(-) A-I      intronic chr7:138758504(-) A-I      intronic chr7:138758528(-) A-I      intronic chr7:138762058(-) A-I      intronic chr7:138737567(-) A-I      intronic chr7:138737618(-) A-I      intronic chr7:138739682(-) A-I      intronic chr7:138739690(-) A-I      intronic chr7:138739753(-) A-I      intronic chr7:138740957(-) A-I      intronic chr7:138740989(-) A-I      intronic chr7:138740999(-) A-I      intronic chr7:138741035(-) A-I      intronic chr7:138774861(-) A-I      intronic chr7:138741060(-) A-I      intronic chr7:138741162(-) A-I      intronic chr7:138741173(-) A-I      intronic chr7:138741216(-) A-I      intronic chr7:138741266(-) A-I      intronic chr7:138741273(-) A-I      intronic chr7:138762154(-) A-I      intronic chr7:138762178(-) A-I      intronic chr7:138741291(-) A-I      intronic chr7:138762217(-) A-I      intronic chr7:138762263(-) A-I      intronic chr7:138768437(-) A-I      intronic chr7:138768446(-) A-I      intronic chr7:138774860(-) A-I      intronic chr7:138741366(-) A-I      intronic chr7:138775989(-) A-I      intronic chr7:138776176(-) A-I      intronic chr7:138780899(-) A-I      intronic chr7:138780901(-) A-I      intronic chr7:138780963(-) A-I      intronic chr7:138780987(-) A-I      intronic chr7:138781033(-) A-I      intronic chr7:138781636(-) A-I      intronic chr7:138755981(-) A-I      intronic chr7:138755971(-) A-I      intronic chr7:138755954(-) A-I      intronic chr7:138781661(-) A-I      intronic chr7:138755652(-) A-I      intronic chr7:138781667(-) A-I      intronic chr7:138781750(-) A-I      intronic chr7:138755646(-) A-I      intronic chr7:138755645(-) A-I      intronic chr7:138755616(-) A-I      intronic chr7:138782302(-) A-I      intronic chr7:138782345(-) A-I      intronic chr7:138782348(-) A-I      intronic chr7:138755606(-) A-I      intronic chr7:138741396(-) A-I      intronic chr7:138741404(-) A-I      intronic chr7:138741417(-) A-I      intronic chr7:138741850(-) A-I      intronic chr7:138741903(-) A-I      intronic chr7:138741992(-) A-I      intronic chr7:138741995(-) A-I      intronic chr7:138742078(-) A-I      intronic chr7:138743068(-) A-I      intronic chr7:138782349(-) A-I      intronic chr7:138743131(-) A-I      intronic chr7:138743148(-) A-I      intronic chr7:138750407(-) A-I      intronic chr7:138782360(-) A-I      intronic chr7:138736031(-) A-I      intronic chr7:138782361(-) A-I      intronic chr7:138782409(-) A-I      intronic chr7:138782439(-) A-I      intronic chr7:138784456(-) A-I      intronic chr7:138784507(-) A-I      intronic chr7:138750426(-) A-I      intronic chr7:138784510(-) A-I      intronic chr7:138784524(-) A-I      intronic chr7:138784525(-) A-I      intronic chr7:138787421(-) A-I      intronic chr7:138787472(-) A-I      intronic chr7:138787659(-) A-I      intronic chr7:138741316(-) A-I      intronic chr7:138741385(-) A-I      intronic chr7:138741399(-) A-I      intronic chr7:138743070(-) A-I      intronic chr7:138786982(-) A-I      intronic chr7:138787004(-) A-I      intronic chr7:138736068(-) A-I      intronic chr7:138733135(-) A-I      intronic chr7:138733227(-) A-I      intronic chr7:138733872(-) A-I      intronic chr7:138733873(-) A-I      intronic chr7:138735821(-) A-I      intronic chr7:138735889(-) A-I      intronic chr7:138735941(-) A-I      intronic chr7:138735942(-) A-I      intronic chr7:138735958(-) A-I      intronic chr7:138736023(-) A-I      intronic chr7:138736041(-) A-I      intronic chr7:138736046(-) A-I      intronic chr7:138736071(-) A-I      intronic chr7:138736076(-) A-I      intronic chr7:138736188(-) A-I      intronic chr7:138736245(-) A-I      intronic chr7:138736268(-) A-I      intronic chr7:138736309(-) A-I      intronic chr7:138736383(-) A-I      intronic chr7:138736397(-) A-I      intronic chr7:138736420(-) A-I      intronic chr7:138737135(-) A-I      intronic chr7:138737150(-) A-I      intronic chr7:138765265(-) A-I      intronic chr7:138737563(-) A-I      intronic chr7:138756052(-) A-I      intronic chr7:138741325(-) A-I      intronic chr7:138781773(-) A-I      intronic chr7:138791322(-) A-I      intronic chr7:138736050(-) A-I      intronic chr7:138752034(-) A-I      intronic chr7:138755935(-) A-I      intronic chr7:138756120(-) A-I      intronic chr7:138735295(-) A-I      intronic chr7:138757933(-) A-I      intronic chr7:138761433(-) A-I      intronic chr7:138789225(-) A-I      intronic chr7:138735389(-) A-I      intronic chr7:138736443(-) A-I      intronic chr7:138774926(-) A-I      intronic chr7:138737424(-) A-I      intronic chr7:138735205(-) A-I      intronic chr7:138788078(-) A-I      intronic chr7:138792284(-) A-I      intronic chr7:138758006(-) A-I      intronic chr7:138783291(-) A-I      intronic chr7:138743084(-) A-I      intronic chr7:138757923(-) A-I      intronic chr7:138755689(-) A-I      intronic chr7:138757962(-) A-I      intronic chr7:138756051(-) A-I      intronic chr7:138781721(-) A-I      intronic chr7:138736291(-) A-I      intronic chr7:138788069(-) A-I      intronic chr7:138741034(-) A-I      intronic chr7:138741253(-) A-I      intronic chr7:138741403(-) A-I      intronic chr7:138774946(-) A-I      intronic chr7:138787633(-) A-I      intronic chr7:138735332(-) A-I      intronic chr7:138761562(-) A-I      intronic chr7:138741891(-) A-I      intronic chr7:138741838(-) A-I      intronic chr7:138757785(-) A-I      intronic chr7:138741327(-) A-I      intronic chr7:138761420(-) A-I      intronic chr7:138742004(-) A-I      intronic chr7:138731989(-) A-I      3'UTR chr7:138741029(-) A-I      intronic chr7:138736098(-) A-I      intronic chr7:138774870(-) A-I      intronic chr7:138774953(-) A-I      intronic chr7:138742071(-) A-I      intronic chr7:138757850(-) A-I      intronic chr7:138733297(-) A-I      intronic chr7:138741043(-) A-I      intronic chr7:138737464(-) A-I      intronic chr7:138756067(-) A-I      intronic chr7:138774726(-) A-I      intronic chr7:138740965(-) A-I      intronic chr7:138762169(-) A-I      intronic chr7:138756026(-) A-I      intronic chr7:138756027(-) A-I      intronic chr7:138752988(-) A-I      intronic chr7:138781827(-) A-I      intronic chr7:138742073(-) A-I      intronic chr7:138791167(-) A-I      intronic chr7:138740959(-) A-I      intronic chr7:138741829(-) A-I      intronic chr7:138781720(-) A-I      intronic chr7:138735900(-) A-I      intronic chr7:138741950(-) A-I      intronic chr7:138781635(-) A-I      intronic chr7:138755980(-) A-I      intronic chr7:138753000(-) A-I      intronic chr7:138735252(-) A-I      intronic chr7:138737628(-) A-I      intronic chr7:138787365(-) A-I      intronic chr7:138757945(-) A-I      intronic chr7:138751991(-) A-I      intronic chr7:138750401(-) A-I      intronic chr7:138735202(-) A-I      intronic chr7:138768397(-) A-I      intronic chr7:138758377(-) A-I      intronic chr7:138743036(-) A-I      intronic chr7:138741371(-) A-I      intronic chr7:138741832(-) A-I      intronic chr7:138787446(-) A-I      intronic chr7:138733287(-) A-I      intronic chr7:138750538(-) A-I      intronic chr7:138752061(-) A-I      intronic chr7:138736242(-) A-I      intronic chr7:138737239(-) A-I      intronic chr7:138776080(-) A-I      intronic chr7:138736449(-) A-I      intronic chr7:138752984(-) A-I      intronic chr7:138758416(-) A-I      intronic chr7:138741982(-) A-I      intronic chr7:138761472(-) A-I      intronic chr7:138750612(-) A-I      intronic chr7:138741892(-) A-I      intronic chr7:138752183(-) A-I      intronic chr7:138761538(-) A-I      intronic chr7:138737645(-) A-I      intronic chr7:138757055(-) A-I      intronic chr7:138737476(-) A-I      intronic chr7:138781711(-) A-I      intronic chr7:138741309(-) A-I      intronic chr7:138751987(-) A-I      intronic chr7:138741380(-) A-I      intronic chr7:138736456(-) A-I      intronic chr7:138776055(-) A-I      intronic chr7:138782453(-) A-I      intronic chr7:138741326(-) A-I      intronic chr7:138741324(-) A-I      intronic chr7:138741313(-) A-I      intronic chr7:138788070(-) A-I      intronic chr7:138781644(-) A-I      intronic chr7:138741314(-) A-I      intronic chr7:138735208(-) A-I      intronic chr7:138741980(-) A-I      intronic chr7:138741163(-) A-I      intronic chr7:138756121(-) A-I      intronic chr7:138757205(-) A-I      intronic chr7:138783330(-) A-I      intronic chr7:138755897(-) A-I      intronic chr7:138753048(-) A-I      intronic chr7:138736299(-) A-I      intronic chr7:138757872(-) A-I      intronic chr7:138743154(-) A-I      intronic chr7:138750395(-) A-I      intronic chr7:138741317(-) A-I      intronic chr7:138782937(-) A-I      intronic chr7:138741434(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZC3HAV1	chr7:138733287(-) A-G intron -    22484847 chr7:138735278(-) A-G intron -    22484847 chr7:138735295(-) A-G intron -    22484847 chr7:138741313(-) A-G intron -    22484847 chr7:138741317(-) A-G intron -    22484847 chr7:138741372(-) A-G intron -    22484847 chr7:138741380(-) A-G intron -    22484847 chr7:138741950(-) A-G intron -    22484847 chr7:138755689(-) A-G intron -    22484847 chr7:138755935(-) A-G intron -    22484847 chr7:138755980(-) A-G intron -    22484847 chr7:138756051(-) A-G intron -    22484847 chr7:138756052(-) A-G intron -    22484847 chr7:138756067(-) A-G intron -    22484847 chr7:138756120(-) A-G intron -    22484847 chr7:138756121(-) A-G intron -    22484847 chr7:138757055(-) A-G intron -    22484847 chr7:138757797(-) A-G intron -    22484847 chr7:138757845(-) A-G intron -    22484847 chr7:138757850(-) A-G intron -    22484847 chr7:138757876(-) A-G intron -    22484847 chr7:138757945(-) A-G intron -    22484847 chr7:138757962(-) A-G intron -    22484847 chr7:138758006(-) A-G intron -    22484847 chr7:138758377(-) A-G intron -    22484847 chr7:138758416(-) A-G intron -    22484847 chr7:138761562(-) A-G intron -    22484847 chr7:138762169(-) A-G intron -    22484847 chr7:138768397(-) A-G intron -    22484847 chr7:138774870(-) A-G intron -    22484847 chr7:138774926(-) A-G intron -    22484847 chr7:138774946(-) A-G intron -    22484847 chr7:138774953(-) A-G intron -    22484847 chr7:138781635(-) A-G intron -    22484847 chr7:138781644(-) A-G intron -    22484847 chr7:138781668(-) A-G intron -    22484847 chr7:138781720(-) A-G intron -    22484847 chr7:138781747(-) A-G intron -    22484847 chr7:138781768(-) A-G intron -    22484847 chr7:138781773(-) A-G intron -    22484847 chr7:138781827(-) A-G intron -    22484847 chr7:138781840(-) A-G intron -    22484847 chr7:138782453(-) A-G intron -    22484847 chr7:138787162(-) A-G intron -    22484847 chr7:138787446(-) A-G intron -    22484847 chr7:138789225(-) A-G intron -    22484847 chr7:138791167(-) A-G intron -    22484847 chr7:138791322(-) A-G intron -    22484847 chr7:138791327(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZC3HAV1	chr7:138728978-138728979(-) m6A 3'UTR       24981863 chr7:138728983-138728984(-) m6A 3'UTR       24981863 chr7:138729001-138729002(-) m6A 3'UTR       24981863 chr7:138729015-138729016(-) m6A 3'UTR       24981863 chr7:138729031-138729032(-) m6A 3'UTR       24981863 chr7:138729050-138729051(-) m6A 3'UTR       24981863 chr7:138729680-138729681(-) m6A 3'UTR       24981863//27773535 chr7:138729754-138729755(-) m6A 3'UTR       24981863//27773535 chr7:138729805-138729806(-) m6A 3'UTR       24981863//27773535 chr7:138729856-138729857(-) m6A 3'UTR       27773535 chr7:138729866-138729867(-) m6A 3'UTR       27773535 chr7:138730399-138730400(-) m6A 3'UTR       27773535 chr7:138730425-138730426(-) m6A 3'UTR       27773535 chr7:138730480-138730481(-) m6A 3'UTR       27773535 chr7:138730538-138730539(-) m6A 3'UTR       27773535 chr7:138731459-138731460(-) m6A 3'UTR       27773535 chr7:138731502-138731503(-) m6A 3'UTR       27773535 chr7:138731556-138731557(-) m6A 3'UTR       27773535 chr7:138734369-138734370(-) m6A intron       27773535 chr7:138734658-138734659(-) m6A intron       27773535 chr7:138734669-138734670(-) m6A intron       27773535 chr7:138734723-138734724(-) m6A intron       27773535 chr7:138745381-138745382(-) m6A 3'UTR//intron       27773535 chr7:138745592-138745593(-) Tm 3'UTR//intron       - chr7:138745831-138745832(-) m6A CDS       - chr7:138745854-138745855(-) m6A CDS       - chr7:138745872-138745873(-) m6A CDS       - chr7:138749644-138749645(-) m6A CDS       - chr7:138764034-138764035(-) m6A CDS//intron       25456834//24981863//27773535//27371828//22608085 chr7:138764116-138764117(-) m6A CDS//intron       24981863//27773535//27371828//22608085 chr7:138764134-138764135(-) m6A CDS//intron       24981863//27773535//27371828//22608085 chr7:138764197-138764198(-) m6A CDS//intron       24981863//27773535//27371828//22608085 chr7:138764288-138764289(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//22575960//22608085 chr7:138764424-138764425(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr7:138764431-138764432(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr7:138764460-138764461(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr7:138764509-138764510(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr7:138764563-138764564(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr7:138764673-138764674(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr7:138764710-138764711(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr7:138764725-138764726(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr7:138764937-138764938(-) Gm CDS       - chr7:138768572-138768573(-) m6A CDS       27773535 chr7:138768581-138768582(-) m6A CDS       27773535 chr7:138768599-138768600(-) m6A CDS       27773535//22575960 chr7:138768638-138768639(-) m6A CDS       27773535//22575960 chr7:138768680-138768681(-) m6A CDS       27773535 chr7:138768712-138768713(-) m6A CDS       27773535 chr7:138774424-138774425(-) m6A CDS       27773535 chr7:138774429-138774430(-) m6A CDS       27773535 chr7:138774438-138774439(-) m6A CDS       27773535 chr7:138793917-138793918(-) m6A CDS       27773536 chr7:138794069-138794070(-) m6A CDS       24981863//27773536 chr7:138794119-138794120(-) m6A 5'UTR       24981863//22575960 chr7:138794153-138794154(-) m6A 5'UTR       24981863//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1915-3p	Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	ZC3HAV1	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1915-3p
Interactor2: ZC3HAV1

Evidence Support:

Weak-Evidence	MiRNA microarray//RNA-Seq
Prediction-Evidence	microRNA.org//PITA//Targetscan
Support Database	ViRBase

References:

PMID	30605755	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	A549 cells	Interactor2 expression	Upregulation
Description	B. Relationships between miRNAs and inversely correlated mRNAs involved in the host defense to virus. Green and red represent downregulated and upregulated genes, while triangles and circles represent miRNAs and target gene mRNAs, respectively.