Detail Information

Basic Information:


  VIRBase ID:  

HHID00092512

  Virus:  

Influenza A virus (A/swine/Guangxi/3861/2011(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1915-3p:           DDX58:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1915-3p DDX58
miRBase
Accession/Entrez ID		 MIMAT0007892 23586
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - RIG-I//RIG1//RIGI//RLR-1//SGMRT2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1915-3p
rs1319660164 chr10:21496576    C/T
rs1335396985 chr10:21496581    C/G
rs1359100620 chr10:21496582    G/A
rs1416262346 chr10:21496578    C/A
rs540277336 chr10:21496579    G/A
rs540277336 chr10:21496579    G/C
rs983068182 chr10:21496591    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DDX58
chr9:32501381(-) A-I      intronic
chr9:32499647(-) A-I      intronic
chr9:32499649(-) A-I      intronic
chr9:32499657(-) A-I      intronic
chr9:32501386(-) A-I      intronic
chr9:32482774(-) A-I      intronic
chr9:32482775(-) A-I      intronic
chr9:32501496(-) A-I      intronic
chr9:32520987(-) A-I      intronic
chr9:32482749(-) A-I      intronic
chr9:32524707(-) A-I      intronic
chr9:32486278(-) A-I      intronic
chr9:32524761(-) A-I      intronic
chr9:32524777(-) A-I      intronic
chr9:32524783(-) A-I      intronic
chr9:32486405(-) A-I      intronic
chr9:32478338(-) A-I      intronic
chr9:32481585(-) A-I      intronic
chr9:32481708(-) A-I      intronic
chr9:32481712(-) A-I      intronic
chr9:32499591(-) A-I      intronic
chr9:32499592(-) A-I      intronic
chr9:32499614(-) A-I      intronic
chr9:32475078(-) A-I      intronic
chr9:32475088(-) A-I      intronic
chr9:32475114(-) A-I      intronic
chr9:32478322(-) A-I      intronic
chr9:32481730(-) A-I      intronic
chr9:32520964(-) A-I      intronic
chr9:32481748(-) A-I      intronic
chr9:32481778(-) A-I      intronic
chr9:32481855(-) A-I      intronic
chr9:32501292(-) A-I      intronic
chr9:32481737(-) A-I      intronic
chr9:32499623(-) A-I      intronic
chr9:32499629(-) A-I      intronic
chr9:32456407(-) A-I      3'UTR
chr9:32456374(-) A-I      3'UTR
chr9:32504018(-) A-I      intronic
chr9:32462601(-) A-I      intronic
chr9:32462576(-) A-I      intronic
chr9:32501394(-) A-I      intronic
chr9:32524686(-) A-I      intronic
chr9:32459156(-) A-I      intronic
chr9:32524833(-) A-I      intronic
chr9:32524708(-) A-I      intronic
chr9:32495796(-) A-I      intronic
chr9:32482794(-) A-I      intronic
chr9:32498818(-) A-I      intronic
chr9:32462985(-) A-I      intronic
chr9:32501291(-) A-I      intronic
chr9:32456507(-) A-I      3'UTR
chr9:32456480(-) A-I      3'UTR
chr9:32456367(-) A-I      3'UTR
chr9:32481829(-) A-I      intronic
chr9:32524679(-) A-I      intronic
chr9:32524755(-) A-I      intronic
chr9:32462963(-) A-I      intronic
chr9:32482677(-) A-I      intronic
chr9:32481777(-) A-I      intronic
chr9:32524706(-) A-I      intronic
chr9:32481878(-) A-I      intronic
chr9:32463039(-) A-I      intronic
chr9:32501275(-) A-I      intronic
chr9:32482748(-) A-I      intronic
chr9:32473422(-) A-I      intronic
chr9:32481681(-) A-I      intronic
chr9:32462625(-) A-I      intronic
chr9:32463047(-) A-I      intronic
chr9:32481754(-) A-I      intronic
chr9:32524716(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DDX58
chr9:32455466(-) A-I exon 3'UTR    15258596
chr9:32456316(-) A-I exon 3'UTR    15258596
chr9:32456318(-) A-I exon 3'UTR    15258596   //21960545
chr9:32456365(-) A-I exon 3'UTR    15258596   //19478186
chr9:32456380(-) A-I exon 3'UTR    15258596
chr9:32456486(-) A-I exon 3'UTR    15258596   //22327324
chr9:32456488(-) A-I exon 3'UTR    15258596
chr9:32456316(-) A-G exon 3'UTR    21725310   //22484847
chr9:32456486(-) A-G exon 3'UTR    21725310
chr9:32479714(-) T-C intron -    22484847
chr9:32456302(-) A-G exon 3'UTR    22484847
chr9:32456318(-) A-G exon 3'UTR    22484847
chr9:32456365(-) A-G exon 3'UTR    22484847
chr9:32456368(-) A-G exon 3'UTR    22484847
chr9:32456371(-) A-G exon 3'UTR    22484847
chr9:32456380(-) A-G exon 3'UTR    22484847
chr9:32456413(-) A-G exon 3'UTR    22484847
chr9:32456449(-) A-G exon 3'UTR    22484847
chr9:32456453(-) A-G exon 3'UTR    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DDX58
chr9:32457063-32457064(-) m6A 3'UTR       24209618//24981863//27773535//27371828//22575960//22608085
chr9:32457168-32457169(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr9:32457190-32457191(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr9:32457256-32457257(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr9:32457294-32457295(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr9:32457362-32457363(-) m6A CDS       24981863//27773535
chr9:32467765-32467766(-) m6A CDS       27773535
chr9:32476997-32476998(-) m6A CDS       27773535
chr9:32477021-32477022(-) m6A CDS       27773535
chr9:32477029-32477030(-) m6A CDS       27773535
chr9:32477065-32477066(-) m6A CDS       27773535
chr9:32477073-32477074(-) m6A CDS       27773535
chr9:32526102-32526103(-) m6A 5'UTR//CDS       24981863
chr9:32526109-32526110(-) m6A 5'UTR//CDS       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1915-3p
Exosome Pooled sera     27278097
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
DDX58
Cytosol HCC cell line (HepG2)|K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1915-3p
Interactor2: DDX58

Evidence Support:


Weak-Evidence MiRNA microarray//RNA-Seq
Prediction-Evidence microRNA.org//PITA//Targetscan
Support Database ViRBase

References:


PMID 30605755 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line A549 cells Interactor2 expression Upregulation
Description A. Relationships between miRNAs and inversely correlated mRNAs involved in the influenza A pathway.

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