Basic Information:

  VIRBase ID:  

HHID00092510

  Virus:  

Influenza A virus (A/swine/Guangxi/3861/2011(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1915-3p:  MIMAT0007892          TLR3:  NM_003265     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1915-3p	TLR3
miRBase Accession/Entrez ID	MIMAT0007892	7098
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD283//IIAE2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1915-3p	rs1319660164 chr10:21496576    C/T rs1335396985 chr10:21496581    C/G rs1359100620 chr10:21496582    G/A rs1416262346 chr10:21496578    C/A rs540277336 chr10:21496579    G/A rs540277336 chr10:21496579    G/C rs983068182 chr10:21496591    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TLR3	chr4:187001863(+) A-I      intronic chr4:187003336(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TLR3	chr4:186990367-186990368(+) m6A 5'UTR       24981863 chr4:186997778-186997779(+) m6A CDS       24981863 chr4:187003525-187003526(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003579-187003580(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003649-187003650(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003659-187003660(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003978-187003979(+) m6A CDS//exon       24981863 chr4:187004022-187004023(+) m6A CDS//exon       24284625//24981863 chr4:187004037-187004038(+) m6A CDS//exon       24284625//24981863 chr4:187004177-187004178(+) m6A CDS//exon       24209618//24981863 chr4:187004260-187004261(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004635-187004636(+) m6A CDS//exon       24981863 chr4:187004686-187004687(+) m6A CDS//exon       24981863 chr4:187004746-187004747(+) m6A CDS//exon       24981863 chr4:187004829-187004830(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004906-187004907(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004932-187004933(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004948-187004949(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187005082-187005083(+) m6A CDS//exon       24284625//24981863 chr4:187005090-187005091(+) m6A CDS//exon       24284625//24981863 chr4:187005095-187005096(+) m6A CDS//exon       24284625//24981863 chr4:187005155-187005156(+) m6A CDS//exon       24284625//24981863 chr4:187005181-187005182(+) m6A CDS//exon       24284625//25456834//24981863 chr4:187005214-187005215(+) m6A CDS//exon       25456834//24981863 chr4:187005236-187005237(+) m6A CDS//exon       25456834//24981863 chr4:187005310-187005311(+) m6A CDS//exon       24981863 chr4:187005888-187005889(+) m6A CDS//exon       24981863 chr4:187005893-187005894(+) m6A CDS//exon       24981863 chr4:187005944-187005945(+) m6A CDS//exon       24981863 chr4:187006013-187006014(+) m6A CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1915-3p	Exosome Pooled sera     27278097 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	TLR3	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1915-3p
Interactor2: TLR3

Evidence Support:

Weak-Evidence	MiRNA microarray//RNA-Seq
Prediction-Evidence	microRNA.org//PITA//Targetscan
Support Database	ViRBase

References:

PMID	30605755	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	A549 cells	Interactor2 expression	Upregulation
Description	A. Relationships between miRNAs and inversely correlated mRNAs involved in the influenza A pathway.