Detail Information

Basic Information:


  VIRBase ID:  

HHID00092498

  Virus:  

Influenza A virus (A/swine/Guangxi/3861/2011(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.9124

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1290:           EGLN3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1290 EGLN3
miRBase
Accession/Entrez ID		 MIMAT0005880 112399
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HIFP4H3//HIFPH3//PHD3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1290
rs1007973249 chr1:18897079    C/T
rs1476283250 chr1:18897083    G/A
rs761060305 chr1:18897085    T/C
rs775733608 chr1:18897080    C/A
rs775733608 chr1:18897080    C/G
rs530117318 chr1:18897094    C/T
rs764376563 chr1:18897093    T/C
rs764376563 chr1:18897093    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR EGLN3
chr14:34405257(-) A-I      intronic
chr14:34396550(-) A-I      intronic
chr14:34405360(-) A-I      intronic
chr14:34405353(-) A-I      intronic
chr14:34578273(-) A-I      intronic
chr14:34415535(-) A-I      intronic
chr14:34395360(-) A-I      intronic
chr14:34578278(-) A-I      intronic
chr14:34396601(-) A-I      intronic
chr14:34415336(-) A-I      intronic
chr14:34413531(-) A-I      intronic
chr14:34413506(-) A-I      intronic
chr14:34411680(-) A-I      intronic
chr14:34411720(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase EGLN3
chr14:34394212-34394213(-) m6A 3'UTR       24981863
chr14:34394229-34394230(-) m6A 3'UTR       24981863
chr14:34394358-34394359(-) m6A 3'UTR       24981863//22575960//22608085
chr14:34394363-34394364(-) m6A 3'UTR       24981863//22575960//22608085
chr14:34394387-34394388(-) m6A 3'UTR       24981863//22575960//22608085
chr14:34394512-34394513(-) m6A 3'UTR       24284625//24981863//28052920//27773535//22575960//22608085
chr14:34394539-34394540(-) m6A 3'UTR       24284625//24981863//28052920//27773535//22575960//22608085
chr14:34394640-34394641(-) m6A 3'UTR       24284625//25456834//24981863//28052920//22575960//22608085
chr14:34394663-34394664(-) m6A 3'UTR       24284625//25456834//24981863//28052920//22608085
chr14:34394777-34394778(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//22608085
chr14:34394859-34394860(-) m6A 3'UTR//exon       24284625//24981863//22608085
chr14:34394927-34394928(-) m6A 3'UTR//exon       24284625//24981863//22608085
chr14:34418529-34418530(-) m6A 3'UTR//intron       24981863
chr14:34418589-34418590(-) m6A 3'UTR//intron       24981863
chr14:34418628-34418629(-) m6A 3'UTR//intron       24284625//24981863
chr14:34418640-34418641(-) m6A 3'UTR//intron       24284625//24981863
chr14:34418650-34418651(-) m6A 3'UTR//intron       24284625//24981863
chr14:34418883-34418884(-) m6A 3'UTR//intron       24284625//24981863
chr14:34418933-34418934(-) m6A 3'UTR//intron       24284625//25456834//24981863
chr14:34419028-34419029(-) m6A 3'UTR//intron       24284625//25456834//24981863
chr14:34419045-34419046(-) m6A 3'UTR//intron       24284625//25456834//24981863
chr14:34419079-34419080(-) m6A 3'UTR//intron       24284625//25456834
chr14:34419245-34419246(-) m6A 3'UTR//intron       -
chr14:34419264-34419265(-) m6A 3'UTR//intron       -
chr14:34419335-34419336(-) m6A 3'UTR//intron       24981863
chr14:34419396-34419397(-) m6A 3'UTR//intron       24981863
chr14:34419863-34419864(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773536//22575960//22608085
chr14:34419929-34419930(-) m6A CDS//intron       24284625//25456834//24981863//28052920//27773536//22575960//22608085
chr14:34419946-34419947(-) m6A CDS//intron       24284625//25456834//24981863//28052920//27773536//22575960//22608085
chr14:34419977-34419978(-) m6A 5'UTR//intron       24284625//25456834//24981863//28052920//27773536//22575960//22608085
chr14:34420057-34420058(-) m6A 5'UTR//intron       24284625//25456834//27773536//22575960//22608085
chr14:34420117-34420118(-) m6A 5'UTR//intron       24284625//27773536
chr14:34454392-34454393(-) m6A exon//intron       -
chr14:34454400-34454401(-) m6A exon//intron       -
chr14:34454436-34454437(-) m6A exon//intron       -
chr14:34454451-34454452(-) m6A exon//intron       -
chr14:34454561-34454562(-) m6A exon//intron       27371828
chr14:34454591-34454592(-) m6A exon//intron       -
chr14:34454666-34454667(-) m6A exon//intron       -
chr14:34454680-34454681(-) m6A exon//intron       -
chr14:34456226-34456227(-) m6A exon//intron       -
chr14:34903479-34903480(-) Y intron       26075521
chr14:34904268-34904269(-) m6A intron       24284625//24981863//26404942//27773535//22608085
chr14:34904287-34904288(-) m6A intron       24284625//24981863//26404942//27773535//22608085
chr14:34904323-34904324(-) m6A intron       24284625//24981863//26404942//27773535//22608085
chr14:34904343-34904344(-) m6A intron       24284625//24981863//26404942//27773535//27371828//22608085
chr14:34904368-34904369(-) m6A intron       24284625//24981863//26404942//27773535//27371828//22608085
chr14:34908159-34908160(-) Tm intron       -
chr14:34911418-34911419(-) Am intron       -
chr14:34931447-34931448(-) m6A intron       24284625//24209618//24981863//27371828//27773536//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1290
Exosome Plasma     23663360
Exosome Chronic lymphocytic leukemia cells     -
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)     -
EGLN3
Chromatin K562 cells     -
Endoplasmic reticulum Human fibrosarcoma cells (HT1080)     25753659
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1290
Gemcitabine 60750 Drug interaction    RC00007727
Eloxatine 5310940 Drug interaction    RC00007731
Epirubicin 41867 Drug interaction    RC00007726
Bortezomib 387447 Drug interaction    RC00007730
Paclitaxel 36314 Drug interaction    RC00007725
5-Fluorouracil 3385 Drug interaction    RC00007724
Emodin 3220 Drug interaction    RC00007723
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007722
Sorafenib 216239 Drug interaction    RC00007729
Ginsenoside Rh2 119307 Drug interaction    RC00007728
platinum-based doublet chemotherapy - Drug interaction    RC00007732
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1290
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1290
Interactor2: EGLN3

Evidence Support:


Strong-Evidence RT-qPCR
Weak-Evidence MiRNA microarray//RNA-Seq
Prediction-Evidence microRNA.org//PITA//Targetscan
Support Database ViRBase

References:


PMID 30605755 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line A549 cells Interactor2 expression Downregulation
Description Table 1. Relationships between 8 miRNAs and inversely correlated 13 target genes selected in RT-qPCR.

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