Basic Information:

  VIRBase ID:  

HHID00092476

  Virus:  

Influenza A virus (A/swine/Guangxi/3861/2011(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-371a-5p:  MIMAT0004687          CXCL8:  NM_000584     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-371a-5p	CXCL8
miRBase Accession/Entrez ID	MIMAT0004687	3576
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GCP-1//GCP1//IL8//LECT//LUCT//LYNAP//MDNCF//MONAP//NAF//NAP-1//NAP1//SCYB8

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-371a-5p	rs1004685112 chr19:53787689    G/C rs1318684148 chr19:53787691    G/C rs772543475 chr19:53787692    G/C rs1034874198 chr19:53787693    G/C rs1049004182 chr19:53787684    A/C rs1049004182 chr19:53787684    A/G rs1185000692 chr19:53787682    T/C rs1202234248 chr19:53787687    C/T rs1428290628 chr19:53787686    A/AC rs1480794990 chr19:53787686    A/C rs770734168 chr19:53787687    CTG/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CXCL8	chr4:74606289-74606290(+) m6A 5'UTR//exon       24981863//26404942 chr4:74606299-74606300(+) m6A 5'UTR//exon       24981863//26404942 chr4:74606324-74606325(+) m6A 5'UTR//exon       24981863//26404942//27773535 chr4:74606341-74606342(+) m6A 5'UTR//exon       24981863//26404942//27773535 chr4:74606354-74606355(+) m6A 5'UTR//exon       24981863//26404942//27773535 chr4:74606373-74606374(+) m6A 5'UTR//exon       24981863//26404942//27773535 chr4:74607286-74607287(+) m6A CDS//exon       27773535 chr4:74607308-74607309(+) m6A CDS//exon       27773535 chr4:74607319-74607320(+) m6A CDS//exon       26404942//27773535 chr4:74607346-74607347(+) m6A CDS//exon       26404942//27773535 chr4:74607367-74607368(+) m6A CDS//exon       26404942//27773535 chr4:74607434-74607435(+) m6A exon//intron       26404942 chr4:74608331-74608332(+) m6A 3'UTR       27773535 chr4:74608370-74608371(+) m6A 3'UTR       27773535 chr4:74608413-74608414(+) m6A 3'UTR       27773535 chr4:74608510-74608511(+) m6A 3'UTR       26404942//27773535 chr4:74608579-74608580(+) m6A 3'UTR       26404942//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-371a-5p	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     - Nucleus Nasopharyngeal carcinoma cells     20498841
	CXCL8	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-371a-5p	10-Hydroxycamptothecin 97226 Drug interaction    RC00007074 Gemcitabine 60750 Drug interaction    RC00007073 Progesterone 5994 Drug interaction    RC00007072 Calcitriol 5280453 Drug interaction    RC00007075 5-Fluorouracil 3385 Drug interaction    RC00007071 Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00007076

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-371a-5p	CID 14440697 14440697       21293479

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-371a-5p
Interactor2: CXCL8

Evidence Support:

Weak-Evidence	MiRNA microarray//RNA-Seq
Prediction-Evidence	microRNA.org//PITA//Targetscan
Support Database	ViRBase

References:

PMID	30605755	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	A549 cells	Interactor2 expression	Upregulation
Description	A. Relationships between miRNAs and inversely correlated mRNAs involved in the influenza A pathway.