Detail Information

Basic Information:


  VIRBase ID:  

HHID00092459

  Virus:  

Influenza A virus (A/swine/Guangxi/3861/2011(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-210-3p:           DHX58:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-210-3p DHX58
miRBase
Accession/Entrez ID		 MIMAT0000267 79132
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - D11LGP2//D11lgp2e//LGP2//RLR-3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-210-3p
rs1220183952 chr11:568118    G/A
rs1241231800 chr11:568112    T/G
rs1280245998 chr11:568115    G/A
rs1344162213 chr11:568120    T/C
rs1355496181 chr11:568117    C/A
rs1355496181 chr11:568117    C/T
rs1490451308 chr11:568121    G/A
rs558661304 chr11:568125    C/T
rs745930382 chr11:568119    C/CT
rs753825152 chr11:568133    G/A
rs753825152 chr11:568133    G/C
rs781628850 chr11:568114    AG/A
rs1247955373 chr11:568128    G/A
rs759616365 chr11:568131    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DHX58
chr17:40256119(-) A-I      intronic
chr17:40255025(-) A-I      intronic
chr17:40256117(-) A-I      intronic
chr17:40256179(-) A-I      intronic
chr17:40256210(-) A-I      intronic
chr17:40258816(-) A-I      intronic
chr17:40254939(-) A-I      intronic
chr17:40254930(-) A-I      intronic
chr17:40255987(-) A-I      intronic
chr17:40255998(-) A-I      intronic
chr17:40255072(-) A-I      intronic
chr17:40258631(-) A-I      intronic
chr17:40255101(-) A-I      intronic
chr17:40254966(-) A-I      intronic
chr17:40256158(-) A-I      intronic
chr17:40254917(-) A-I      intronic
chr17:40254904(-) A-I      intronic
chr17:40254975(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DHX58
chr17:40253673(-) A-C exon 3'UTR    21725310

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DHX58
chr17:40253537-40253538(-) m6A 3'UTR       28052920//27773535
chr17:40253570-40253571(-) m6A 3'UTR       28052920//27773535
chr17:40253591-40253592(-) m6A 3'UTR       28052920//27773535
chr17:40253619-40253620(-) m6A 3'UTR//exon       27773535
chr17:40253719-40253720(-) m6A 3'UTR//exon       27371828
chr17:40253782-40253783(-) m6A 3'UTR//CDS//exon       27371828
chr17:40253794-40253795(-) m6A 3'UTR//CDS//exon       27371828
chr17:40253803-40253804(-) m6A 3'UTR//CDS//exon       27371828
chr17:40253891-40253892(-) m6A 3'UTR//CDS//exon       27371828
chr17:40254243-40254244(-) m6A 3'UTR//CDS//exon       -
chr17:40254276-40254277(-) m6A 3'UTR//CDS//exon       -
chr17:40254327-40254328(-) m6A CDS//exon       -
chr17:40254407-40254408(-) m6A exon//intron       -
chr17:40254485-40254486(-) m6A exon//intron       27773535
chr17:40254528-40254529(-) m6A exon//intron       27773535
chr17:40254554-40254555(-) m6A exon//intron       27773535
chr17:40254563-40254564(-) m6A exon//intron       27773535
chr17:40254575-40254576(-) m6A exon//intron       27773535
chr17:40254667-40254668(-) m6A exon//intron       27773535
chr17:40255754-40255755(-) m6A CDS//exon//intron       27371828
chr17:40256805-40256806(-) m6A CDS//exon       27371828
chr17:40257138-40257139(-) m6A CDS//exon       27371828
chr17:40257145-40257146(-) m6A CDS//exon       27371828
chr17:40257180-40257181(-) m6A CDS//exon       27371828
chr17:40257781-40257782(-) m6A CDS//exon//intron       27371828
chr17:40257814-40257815(-) m6A CDS//exon//intron       27371828
chr17:40257821-40257822(-) m6A CDS//exon//intron       27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-210-3p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Plasma     19289371
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome B lymphoblastoid cells|Endothelial cells|Epithelial cells|Lymphoma tissue|Mast cells|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Myotube     27396686
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Colon adenocarcinoma cells     20864815
Nucleus Neural progenitor cells     21363885
DHX58
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-210-3p
N~4~-(3-Methyl-1h-Indazol-6-Yl)-N~2~-(3,4,5-Trimethoxyphenyl)pyrimidine-2,4-Diamine 9822610 Drug sensitive
Cyclo[N-methyl-L-alanyl-beta-alanyl-(2R)-2-hydroxy-4-pentenoyl-L-prolyl-L-isoleucyl-N-methyl-L-valyl] 91746256 Drug resistant
Piperidinium pentamethylenedithiocarbamate 72508 Drug resistant
Tolonium chloride 7083 Drug resistant
3-Hydroxy-3'-nitro-2-naphthanilide 67277 Drug resistant
Pyrazolo[1,5-b]pyridazine deriv. 40 6539382 Drug sensitive
Cytarabine 6253 Drug resistant
Adenosine, 2-bromo-2'-deoxy- 55914 Drug resistant
Di-p-tolyliodinium bromide 54601177 Drug resistant
Herbimycin 5311102 Drug resistant
Asimicinone 393461 Drug resistant
7-Chloro-6-(2-fluoroethylamino)quinoline-5,8-dione 379079 Drug resistant
2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant
1H-Benz[g]indol-5-ol, 2-phenyl 371327 Drug resistant
Diethoxybis(1,4-naphthochinone-2-olato)titanium(IV) 368297 Drug resistant
Diisopropoxybis(1,4-naphthochinone-2-olato)titanium(IV) 368058 Drug resistant
10-(2,4-Dichlorophenyl)-3-methylbenzo[g]pteridine-2,4-dione 362038 Drug resistant
2,3-Dimethylbenzo[g]quinoxaline-5,10-dione 353644 Drug resistant
3'-Chloro-2-hydroxy-2'-methyl-3-nitrobenzanilide 332278 Drug resistant
Acetylstrophanthidin 261075 Drug resistant
Scillirosidin, glycoside 222160 Drug resistant
Sesbanimide 163490 Drug resistant
(1R,6R,13S)-16,17-Dimethoxy-6-propan-2-yl-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one 13845974 Drug resistant
Methyl (7E,9Z,11R,12S,13R,14R,15R,17R,18S,19S,20E)-2,16-diacetyloxy-12,14,18,19,31-pentahydroxy-3,7,11,13,17,19,21,27-octamethyl-6,28-dioxo-23,25-dioxa-5-azatetracyclo[20.7.1.14,29.026,30]hentriaconta-1,3,7,9,20,22(30),26,29(31)-octaene-15-carboxylate 138319083 Drug resistant
(2R,4R,6S,7S,12S)-6,7,16-Trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.02,4]nonadeca-1(15),9,16,18-tetraene-8,14-dione 131676399 Drug resistant
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 2-phenyl- - Drug resistant
benzo[b]naphtho[2,3-d]furan-6,11-dione, 4-chloro-3-hydroxy - Drug resistant
naphtho[2,3-d]-1,3-dioxepin-6,11-dione, 4-methyl- - Drug resistant
naphtho[2,3-d]oxazole-4,9-dione, 2-(1,1-dimethylethyl)- - Drug resistant
b705009k098 - Drug resistant
discorhabdin i - Drug resistant
o-linoleoyl-2-butoxy-1-desoamine - Drug resistant
indole-2,3-dione, 5-methyl-, 3-[(o-nitrophenyl)hydrazone] - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-210-3p
Curcumin 969516 Drug interaction    RC00002040
Oxaliplatine 6857599 Drug interaction    RC00002041
Capecitabine 60953 Drug interaction    RC00002033
Gemcitabine 60750 Drug interaction    RC00002032
Vincristine 5978 Drug interaction    RC00002026
Alanine 5950 Drug interaction    RC00002025
Dexamethasone 5743 Drug interaction    RC00002024
Temozolomide 5394 Drug interaction    RC00002023
Imatinib 5291 Drug interaction    RC00002022
Goserelinacetate 47725 Drug interaction    RC00002031
Decitabine 451668 Drug interaction    RC00002039
Paclitaxel 36314 Drug interaction    RC00002030
5-Fluorouracil 3385 Drug interaction    RC00002021
Doxorubicin 31703 Drug interaction    RC00002029
Daunorubicin 30323 Drug interaction    RC00002028
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002020
Bicalutamide 2375 Drug interaction    RC00002019
Lenalidomide 216326 Drug interaction    RC00002038
Lapatinib 208908 Drug interaction    RC00002037
Arsenic trioxide 14888 Drug interaction    RC00002027
Docetaxel 148124 Drug interaction    RC00002036
Leucovorin 135403648 Drug interaction    RC00002042
Methotrexate 126941 Drug interaction    RC00002035
Ginsenoside Rh2 119307 Drug interaction    RC00002034
Asparaginase Escherichia coli - Drug interaction    RC00002043
Trastuzumab - Drug interaction    RC00002044
Aidi injection - Drug interaction    RC00002045
Olea europaea leaf extract - Drug interaction    RC00002046
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-210-3p
Cisplatin 5702198       30957179
5-Fluorouracil 3385       25356050

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-210-3p
Interactor2: DHX58

Evidence Support:


Weak-Evidence MiRNA microarray//RNA-Seq
Prediction-Evidence microRNA.org//PITA//Targetscan
Support Database ViRBase

References:


PMID 30605755 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line A549 cells Interactor2 expression Upregulation
Description B. Relationships between miRNAs and inversely correlated mRNAs involved in the host defense to virus. Green and red represent downregulated and upregulated genes, while triangles and circles represent miRNAs and target gene mRNAs, respectively.

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