Detail Information

Basic Information:


  VIRBase ID:  

HHID00092443

  Virus:  

Influenza A virus (A/Puerto Rico/8/1934(H1N1))

  Host:  

Mus musculus

  Confidence Score:  

0.9751

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-451a:           Ywhaz:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol mmu-miR-451a Ywhaz
miRBase
Accession/Entrez ID		 MIMAT0001632 22631
Organism Mus musculus Mus musculus
Category miRNA mRNA
Alias - 1110013I11Rik//14-3-3zeta//AI596267//AL022924//AU020854

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR Ywhaz
chr15:36713119(-) A-I      intronic
chr15:36714265(-) A-I      intronic
chr15:36713140(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED Ywhaz
chr15:36783364(-) A-I intron -    22524474
chr15:36783385(-) A-I intron -    22524474
chr15:36784510(-) A-I intron -    22524474

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase Ywhaz
chr15:36770904-36770905(-) m6A 3'UTR       24981863//25569111//22608085
chr15:36770911-36770912(-) m6A 3'UTR       24981863//25569111//22608085
chr15:36771484-36771485(-) m6A 3'UTR       24981863//25456834//26404942
chr15:36771548-36771549(-) Y 3'UTR//exon       26075521
chr15:36771553-36771554(-) m6A 3'UTR       24981863//25456834//26404942//22608085
chr15:36771646-36771647(-) m6A 3'UTR       24981863//26404942//22608085
chr15:36771703-36771704(-) m6A 3'UTR       24981863//22608085
chr15:36771751-36771752(-) m6A 3'UTR       24981863
chr15:36771775-36771776(-) m6A 3'UTR       24981863
chr15:36771974-36771975(-) m6A 3'UTR       24981863
chr15:36775278-36775279(-) m6A CDS//exon       22608085
chr15:36775310-36775311(-) m6A CDS//exon       22608085
chr15:36775417-36775418(-) m6A CDS//exon       22608085
chr15:36775449-36775450(-) m6A CDS//exon       22608085
chr15:36775496-36775497(-) m6A CDS//exon       22608085
chr15:36775552-36775553(-) Y CDS//exon       26075521
chr15:36775569-36775570(-) m6A CDS//exon       22608085
chr15:36790852-36790853(-) m6A CDS//exon       24981863//25569111
chr15:36792153-36792154(-) m6A 5'UTR//intron       24981863//25456834//25569111
chr15:36793483-36793484(-) m6A 5'UTR//exon//intron       25412662//24981863//25456834//25569111//22575960
chr15:36793521-36793522(-) m6A 5'UTR//intron       25412662//24981863//25456834//25569111//22575960
chr15:36793569-36793570(-) m6A 5'UTR//intron       25412662//24981863//25456834//25569111//22575960
chr15:36793617-36793618(-) m6A 5'UTR//intron       25412662//24981863//25569111
chr15:36793707-36793708(-) m6A 5'UTR//intron       25683224//25412662//24981863//25569111

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate mmu-miR-451a
Exosome Mast cells     17486113
Exosome B6 BMDCs     22031862
Exosome Mouse hypothalamic neuronal cell line (GT1-7)     22965126
Mitochondrion Heart tissue (subsarcolemmal and interfibrillar)     26377859
Nucleus Liver cells     21862971
Synaptoneurosome ForeBrain     18410515
Ywhaz
Exosome Mast cells     17486113

Interaction Network (The top 100 interactions):


Interactor1: mmu-miR-451a
Interactor2: Ywhaz

Evidence Support:


Strong-Evidence qRT-PCR//RT-PCR//Western blot
Weak-Evidence Microarray
Support Database ViRBase

References:


PMID 23169590 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line CD8(+) T cells//Splenic dendritic cells Interactor2 expression Downregulation
Description We used quantitative RT-PCR to confirm that miR-451 is increased following influenza infection for 8 hours. miR-451 regulates dendritic cell cytokine responses to influenza infection. Inhibition of miR-451 expression correlated with increased YWHAZ protein expression and decreased ZFP36 expression, providing a possible mechanism for the elevated secretion of IL-6, TNF, CCL5/RANTES, and CCL3/MIP1 alpha.

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