Basic Information:

  VIRBase ID:  

HHID00092442

  Virus:  

Influenza A virus (A/Puerto Rico/8/1934(H1N1))

  Host:  

Mus musculus

  Confidence Score:  

0.9374

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-451a:  MIMAT0001632          Ccl5:  NM_013653     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-451a	Ccl5
miRBase Accession/Entrez ID	MIMAT0001632	20304
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	MuRa//MuRantes//RA//RANTES//S//Scy//Scya5//SISd//TCP22//TCP228

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-451a	Exosome Mast cells     17486113 Exosome B6 BMDCs     22031862 Exosome Mouse hypothalamic neuronal cell line (GT1-7)     22965126 Mitochondrion Heart tissue (subsarcolemmal and interfibrillar)     26377859 Nucleus Liver cells     21862971 Synaptoneurosome ForeBrain     18410515

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-451a
Interactor2: Ccl5

Evidence Support:

Strong-Evidence	qRT-PCR//RT-PCR
Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	23169590	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	CD8(+) T cells//Splenic dendritic cells	Interactor2 expression	None
Description	We used quantitative RT-PCR to confirm that miR-451 is increased following influenza infection for 8 hours. miR-451 regulates dendritic cell cytokine responses to influenza infection. Inhibition of miR-451 expression correlated with increased YWHAZ protein expression and decreased ZFP36 expression, providing a possible mechanism for the elevated secretion of IL-6, TNF, CCL5/RANTES, and CCL3/MIP1 alpha.