Basic Information:

  VIRBase ID:  

HHID00092440

  Virus:  

Influenza A virus (A/Puerto Rico/8/1934(H1N1))

  Host:  

Mus musculus

  Confidence Score:  

0.9374

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-451a:  MIMAT0001632          Il6:  NM_001314054     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-451a	Il6
miRBase Accession/Entrez ID	MIMAT0001632	16193
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	Il//Il-6

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Il6	chr5:30014859-30014860(+) m6A CDS       25412662 chr5:30014883-30014884(+) m6A CDS       25412662 chr5:30014893-30014894(+) m6A CDS       25412662 chr5:30014930-30014931(+) m6A CDS       25412662 chr5:30019470-30019471(+) m6A 3'UTR//CDS       24981863 chr5:30019476-30019477(+) m6A 3'UTR//CDS       24981863 chr5:30019542-30019543(+) m6A 3'UTR//CDS       24981863 chr5:30019578-30019579(+) m6A 3'UTR       24981863 chr5:30019648-30019649(+) m6A 3'UTR       24981863 chr5:30019669-30019670(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-451a	Exosome Mast cells     17486113 Exosome B6 BMDCs     22031862 Exosome Mouse hypothalamic neuronal cell line (GT1-7)     22965126 Mitochondrion Heart tissue (subsarcolemmal and interfibrillar)     26377859 Nucleus Liver cells     21862971 Synaptoneurosome ForeBrain     18410515

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-451a
Interactor2: Il6

Evidence Support:

Strong-Evidence	qRT-PCR//RT-PCR
Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	23169590	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	CD8(+) T cells//Splenic dendritic cells	Interactor2 expression	Upregulation
Description	We used quantitative RT-PCR to confirm that miR-451 is increased following influenza infection for 8 hours. miR-451 regulates dendritic cell cytokine responses to influenza infection. Inhibition of miR-451 expression correlated with increased YWHAZ protein expression and decreased ZFP36 expression, providing a possible mechanism for the elevated secretion of IL-6, TNF, CCL5/RANTES, and CCL3/MIP1 alpha.