Basic Information:

  VIRBase ID:  

HHID00092439

  Virus:  

Influenza A virus (A/Puerto Rico/8/1934(H1N1))

  Host:  

Mus musculus

  Confidence Score:  

0.7311

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-155-5p:  MIMAT0000165          Il6:  NM_001314054     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-155-5p	Il6
miRBase Accession/Entrez ID	MIMAT0000165	16193
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	Il//Il-6

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Il6	chr5:30014859-30014860(+) m6A CDS       25412662 chr5:30014883-30014884(+) m6A CDS       25412662 chr5:30014893-30014894(+) m6A CDS       25412662 chr5:30014930-30014931(+) m6A CDS       25412662 chr5:30019470-30019471(+) m6A 3'UTR//CDS       24981863 chr5:30019476-30019477(+) m6A 3'UTR//CDS       24981863 chr5:30019542-30019543(+) m6A 3'UTR//CDS       24981863 chr5:30019578-30019579(+) m6A 3'UTR       24981863 chr5:30019648-30019649(+) m6A 3'UTR       24981863 chr5:30019669-30019670(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-155-5p	Exosome Mouse metastatic mammary carcinoma cells (4T1)|Non-tumorigenic mouse mammary epithelial cells (NMuMG)     25446899 Exosome Bone marrow-derived dendritic cells     26084661 Exosome Serum     28160157 Exosome B6 BMDCs     22031862 Exosome Mouse hypothalamic neuronal cell line (GT1-7)     22965126 Exosome Bone marrow-derived macrophages     25159140 Mitochondrion Hippocampus neuron|Liver tissue     27396686 Mitochondrion Liver tissue     20733615 Nucleus Cortex neurons|Hippocampus neurons     28804446

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-155-5p
Interactor2: Il6

Evidence Support:

Strong-Evidence	qPCR
Support Database	ViRBase

References:

PMID	24876306	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	HEK293T cells//MDCK cells	Interactor2 expression	Upregulation
Description	Using qPCR and dual luciferase technology we show that miR-155 delivery resulted in a significant increase in cellular miR-155 which facilitated a downregulation of SOCS1 gene expression and a functional increase in IL-6 and IFN-beta cytokines.