Basic Information:

  VIRBase ID:  

HHID00092414

  Virus:  

Influenza A virus (A/Puerto Rico/8/1934(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-148a-5p:  MIMAT0004549          CDKN1B:  NM_004064     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-148a-5p	CDKN1B
miRBase Accession/Entrez ID	MIMAT0004549	1027
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CDKN4//KIP1//MEN1B//MEN4//P27KIP1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-148a-5p	rs1169404442 chr7:25949960    A/G rs1305387183 chr7:25949963    C/T rs1340640170 chr7:25949981    T/C rs1382103906 chr7:25949968    T/C rs1392050107 chr7:25949964    G/A rs752022883 chr7:25949961    G/A rs758401446 chr7:25949962    TC/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CDKN1B	chr12:12868290(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CDKN1B	chr12:12870457-12870458(+) m6A 5'UTR//intron       24284625//24981863//22575960//22608085 chr12:12870481-12870482(+) m6A 5'UTR//intron       24284625//24981863//22575960//22608085 chr12:12870568-12870569(+) m6A 5'UTR//intron       - chr12:12870760-12870761(+) m6A 5'UTR//intron       24209618//24981863//22608085 chr12:12870864-12870865(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr12:12870882-12870883(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr12:12870903-12870904(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr12:12870921-12870922(+) Gm CDS//intron       - chr12:12870924-12870925(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr12:12870976-12870977(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:12871042-12871043(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr12:12871152-12871153(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr12:12871167-12871168(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:12871175-12871176(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:12871188-12871189(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:12871773-12871774(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:12871790-12871791(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:12871880-12871881(+) m6A 3'UTR//exon//intron       24284625//24981863//22608085 chr12:12874075-12874076(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//22608085 chr12:12874098-12874099(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//27773535//22608085 chr12:12874247-12874248(+) m6A 3'UTR       24981863//22608085 chr12:12874282-12874283(+) m6A 3'UTR       24981863 chr12:12875101-12875102(+) m6A 3'UTR       27773535 chr12:12875290-12875291(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-148a-5p	Exosome Peripheral blood     31746410 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Seminal fluid     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	CDKN1B	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-148a-5p
Interactor2: CDKN1B

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA
Support Database	ViRBase

References:

PMID	31985023	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	In the predication analysis, NEAT1 targeted 144 mRNAs through miRNAs (Table III).