Detail Information

Basic Information:


  VIRBase ID:  

HHID00092394

  Virus:  

Influenza A virus (A/Puerto Rico/8/1934(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-151a-3p:           MYL9:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-151a-3p MYL9
miRBase
Accession/Entrez ID		 MIMAT0000757 10398
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - LC20//MLC-2C//MLC2//MRLC1//MYRL2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-151a-3p
rs1264540051 chr8:140732598    T/C
rs746613804 chr8:140732607    G/A
rs746613804 chr8:140732607    G/C
rs753985396 chr8:140732596    G/A
rs925869245 chr8:140732595    A/G
rs969840716 chr8:140732590    C/T
rs980027590 chr8:140732591    A/C
rs1026367443 chr8:140732600    C/T
rs755215032 chr8:140732605    T/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MYL9
chr20:35175750(+) A-I      intronic
chr20:35173712(+) A-I      intronic
chr20:35174056(+) A-I      intronic
chr20:35175752(+) A-I      intronic
chr20:35175759(+) A-I      intronic
chr20:35175760(+) A-I      intronic
chr20:35175764(+) A-I      intronic
chr20:35175768(+) A-I      intronic
chr20:35175772(+) A-I      intronic
chr20:35175773(+) A-I      intronic
chr20:35175782(+) A-I      intronic
chr20:35175807(+) A-I      intronic
chr20:35175810(+) A-I      intronic
chr20:35175315(+) A-I      intronic
chr20:35175811(+) A-I      intronic
chr20:35176024(+) A-I      intronic
chr20:35176036(+) A-I      intronic
chr20:35175763(+) A-I      intronic
chr20:35176045(+) A-I      intronic
chr20:35176046(+) A-I      intronic
chr20:35176050(+) A-I      intronic
chr20:35174037(+) A-I      intronic
chr20:35175739(+) A-I      intronic
chr20:35175730(+) A-I      intronic
chr20:35175731(+) A-I      intronic
chr20:35175735(+) A-I      intronic
chr20:35175740(+) A-I      intronic
chr20:35173700(+) A-I      intronic
chr20:35175271(+) A-I      intronic
chr20:35175112(+) A-I      intronic
chr20:35175074(+) A-I      intronic
chr20:35175061(+) A-I      intronic
chr20:35175039(+) A-I      intronic
chr20:35174219(+) A-I      intronic
chr20:35174148(+) A-I      intronic
chr20:35174146(+) A-I      intronic
chr20:35174084(+) A-I      intronic
chr20:35175744(+) A-I      intronic
chr20:35175106(+) A-I      intronic
chr20:35175093(+) A-I      intronic
chr20:35175087(+) A-I      intronic
chr20:35175049(+) A-I      intronic
chr20:35175043(+) A-I      intronic
chr20:35175042(+) A-I      intronic
chr20:35175037(+) A-I      intronic
chr20:35174310(+) A-I      intronic
chr20:35174273(+) A-I      intronic
chr20:35174251(+) A-I      intronic
chr20:35174244(+) A-I      intronic
chr20:35174243(+) A-I      intronic
chr20:35174212(+) A-I      intronic
chr20:35174172(+) A-I      intronic
chr20:35174171(+) A-I      intronic
chr20:35174167(+) A-I      intronic
chr20:35174155(+) A-I      intronic
chr20:35175113(+) A-I      intronic
chr20:35173651(+) A-I      intronic
chr20:35173654(+) A-I      intronic
chr20:35173715(+) A-I      intronic
chr20:35173721(+) A-I      intronic
chr20:35173722(+) A-I      intronic
chr20:35173723(+) A-I      intronic
chr20:35173734(+) A-I      intronic
chr20:35173737(+) A-I      intronic
chr20:35173738(+) A-I      intronic
chr20:35173741(+) A-I      intronic
chr20:35173743(+) A-I      intronic
chr20:35173747(+) A-I      intronic
chr20:35173748(+) A-I      intronic
chr20:35173749(+) A-I      intronic
chr20:35173750(+) A-I      intronic
chr20:35173758(+) A-I      intronic
chr20:35173789(+) A-I      intronic
chr20:35173806(+) A-I      intronic
chr20:35175274(+) A-I      intronic
chr20:35175290(+) A-I      intronic
chr20:35175287(+) A-I      intronic
chr20:35175276(+) A-I      intronic
chr20:35173740(+) A-I      intronic
chr20:35174087(+) A-I      intronic
chr20:35173820(+) A-I      intronic
chr20:35173828(+) A-I      intronic
chr20:35173895(+) A-I      intronic
chr20:35174070(+) A-I      intronic
chr20:35175265(+) A-I      intronic
chr20:35175262(+) A-I      intronic
chr20:35175261(+) A-I      intronic
chr20:35175233(+) A-I      intronic
chr20:35175222(+) A-I      intronic
chr20:35175202(+) A-I      intronic
chr20:35175187(+) A-I      intronic
chr20:35175179(+) A-I      intronic
chr20:35175178(+) A-I      intronic
chr20:35175154(+) A-I      intronic
chr20:35175130(+) A-I      intronic
chr20:35175115(+) A-I      intronic
chr20:35174079(+) A-I      intronic
chr20:35174180(+) A-I      intronic
chr20:35174272(+) A-I      intronic
chr20:35174181(+) A-I      intronic
chr20:35174156(+) A-I      intronic
chr20:35174173(+) A-I      intronic
chr20:35173713(+) A-I      intronic
chr20:35174078(+) A-I      intronic
chr20:35173753(+) A-I      intronic
chr20:35174179(+) A-I      intronic
chr20:35174170(+) A-I      intronic
chr20:35174185(+) A-I      intronic
chr20:35173821(+) A-I      intronic
chr20:35174182(+) A-I      intronic
chr20:35174176(+) A-I      intronic
chr20:35175165(+) A-I      intronic
chr20:35175142(+) A-I      intronic
chr20:35175196(+) A-I      intronic
chr20:35173637(+) A-I      intronic
chr20:35173646(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MYL9
chr20:35170667(+) A-I intron -    15342557
chr20:35173637(+) A-I intron -    15258596
chr20:35173645(+) A-I intron -    15342557   //15258596
chr20:35173646(+) A-I intron -    15342557   //15258596
chr20:35173667(+) A-I intron -    15258596
chr20:35173713(+) A-I intron -    15342557   //15258596
chr20:35173753(+) A-I intron -    15342557
chr20:35173779(+) A-I intron -    15342557
chr20:35173785(+) A-I intron -    15342557
chr20:35173821(+) A-I intron -    15342557
chr20:35175142(+) A-I intron -    15258596
chr20:35175152(+) A-I intron -    15258596
chr20:35175165(+) A-I intron -    15258596
chr20:35175193(+) A-I intron -    15258596
chr20:35175196(+) A-I intron -    15258596
chr20:35175213(+) A-I intron -    15258596
chr20:35175283(+) A-I intron -    15258596

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MYL9
chr20:35169905-35169906(+) m6A 5'UTR       24284625//25456834//24981863
chr20:35173314-35173315(+) m6A CDS       24284625//25456834//24981863//22575960
chr20:35173417-35173418(+) m6A CDS       24284625//24981863//22575960
chr20:35173444-35173445(+) m6A CDS       24284625//24981863
chr20:35176440-35176441(+) m6A CDS//intron       24284625
chr20:35177791-35177792(+) m6A 3'UTR       24284625//22575960
chr20:35177884-35177885(+) m6A 3'UTR       24284625//25456834//22575960
chr20:35177898-35177899(+) m6A 3'UTR       24284625//25456834//22575960
chr20:35177917-35177918(+) m6A 3'UTR       24284625//25456834//22575960
chr20:35178025-35178026(+) m6A 3'UTR       24284625//25456834//22575960
chr20:35178176-35178177(+) m6A 3'UTR       24284625//24981863//22575960
chr20:35178213-35178214(+) m6A 3'UTR       24284625//24981863
chr20:35179578-35179579(+) m6A 3'UTR       -
chr20:35179604-35179605(+) m6A 3'UTR       -
chr20:35179672-35179673(+) m6A 3'UTR       -
chr20:35179689-35179690(+) m6A 3'UTR       -
chr20:35179703-35179704(+) m6A 3'UTR       -
chr20:35179712-35179713(+) m6A 3'UTR       -
chr20:35179733-35179734(+) m6A 3'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-151a-3p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Peripheral blood mononuclear cells     19002258
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
MYL9
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-151a-3p
S-Decyl p-toluenethiosulfonate 97461 Drug resistant
5-Iodo-8-quinolinol 96111 Drug resistant
[[4-(3-Aminophenyl)-2-pyridyl]methyleneamino]thiourea 9556427 Drug resistant
Dichlorodipropylstannane 93562 Drug resistant
Jacaranone 73307 Drug resistant
Reactive Blue 2 656725 Drug resistant
Caracemide 54747 Drug resistant
p-Chloranilinum[bis(p-chloraniline)dioxalatoruthenate(III)] 54608061 Drug resistant
(E)-1-(2,5-Dihydroxyphenyl)ethene-2-isonitrile 5388136 Drug resistant
Erioflorin acetate 5281443 Drug resistant
Kekule 499328 Drug resistant
Ammonia; dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498559 Drug resistant
Oridonin (thiol adduct OF) 432952 Drug resistant
2-[(Phenylamino)methyl]benzene-1,4-diol 403336 Drug resistant
3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug sensitive
3,8-Dimethyl-1,2-naphthoquinone 373912 Drug resistant
Dmask 32465 Drug resistant
1,1-Dimethyl-5-(2-naphthalenyl)dithiobiuret 3004012 Drug resistant
Dichloroallyl lawsone 277767 Drug resistant
Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug resistant
Dibutyltin dichloride 12688 Drug resistant
Melampodinin 11953936 Drug resistant
p-Toluquinone 11122 Drug resistant
(7S,9S)-7-[[(3As,4S,7aS)-1-[[(3aS,4S,7aS)-4-methyl-6-[[(1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl]oxy]-2,3a,4,6,7,7a-hexahydropyrano[4,3-d][1,3]oxazol-1-yl]methyl]-4-methyl-2,3a,4,6,7,7a-hexahydropyrano[4,3-d][1,3]oxazol-6-yl]oxy]-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione 101713728 Drug resistant
(1s,2e,4r,7e,11e)-4-hydroxy-2,7,11-cembratrien-6-one - Drug resistant
(E)-2-(2-(benzo[d][1,3]dioxol-5-yl)vinyl)-5-(3-methyl-1H-pyrazol-5-yl)-1,3,4-oxadiazole - Drug resistant
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug resistant
4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug resistant
benzene, 1,1'-[(1,3-butadiene-1,4-diyl)sulfonyl]bis - Drug resistant
cis-difluorobis(1-phenylhexane-1,3-dionato)titanium(iv) - Drug resistant
cyclopentanone, 2,5-bis[(trimethylamino)methyl]-, iodide - Drug resistant
n,n'-bis(oxydiethylene)thiocarbamoylsulfenamide - Drug resistant
phenol, 4,4'-(5,5'-biisoxazole-3,3'-diyl)bis- - Drug resistant
piceatannol, 4,3',5'-trimethyl,1s0 - Drug resistant
tris(1,3-diphenylpropane-1,3-dionata)gallium(iii) - Drug resistant
[bis(aminomethyl)diethylsilane]dichloroplatinum (ii) - Drug resistant
4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug resistant
7-propanoyltaxol - Drug resistant
maleimide carbazole - Drug resistant
methyl 3-farnesylthioacetate - Drug resistant
n-acetyl-4-s-cystaminyl phenol - Drug resistant
antineoplastic-d655481 - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-151a-3p
Formaldehyde 712 Drug interaction    RC00004380
Gemcitabine 60750 Drug interaction    RC00004386
Eloxatine 5310940 Drug interaction    RC00004392
Imatinib 5291 Drug interaction    RC00004383
Genistein 5280961 Drug interaction    RC00004391
Cholecalciferol 5280795 Drug interaction    RC00004390
Paroxetine 43815 Drug interaction    RC00004385
5-Fluorouracil 3385 Drug interaction    RC00004382
Doxorubicin 31703 Drug interaction    RC00004384
Tamoxifen 2733526 Drug interaction    RC00004389
Verapamil 2520 Drug interaction    RC00004381
Docetaxel 148124 Drug interaction    RC00004388
Ginsenoside Rh2 119307 Drug interaction    RC00004387
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00004393
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-151a-3p
Imatinib 5291       25349971

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-151a-3p
Interactor2: MYL9

Evidence Support:


Weak-Evidence MiRNA microarray
Prediction-Evidence microRNA.org//PITA//Targetscan
Support Database ViRBase

References:


PMID 29059211 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HUVECs Interactor2 expression None
Description The differential miRNAs and their target genes in the above pathways were concluded in Table S1 and Table S2.

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