Basic Information:

  VIRBase ID:  

HHID00092348

  Virus:  

Influenza A virus (A/Puerto Rico/8/1934(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-23b-3p:  MIMAT0000418          VEGFA:  NM_001171622     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-23b-3p	VEGFA
miRBase Accession/Entrez ID	MIMAT0000418	7422
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MVCD1//VEGF//VPF

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-23b-3p	rs1165985173 chr9:95085265    A/G rs1316630116 chr9:95085276    A/G rs1356837387 chr9:95085278    G/T rs567029494 chr9:95085287    C/A rs567029494 chr9:95085287    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	VEGFA	chr6:43738036-43738037(+) m6A 5'UTR//exon       24981863 chr6:43738048-43738049(+) m6A 5'UTR//exon       24981863 chr6:43738124-43738125(+) m6A 5'UTR//exon       24981863 chr6:43738139-43738140(+) m6A 5'UTR//exon       24284625 chr6:43738249-43738250(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr6:43738450-43738451(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:43738458-43738459(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:43738509-43738510(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:43738601-43738602(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:43738738-43738739(+) m1A 5'UTR//CDS//exon       26863196//26863410 chr6:43738825-43738826(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:43738980-43738981(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960 chr6:43738987-43738988(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960 chr6:43741786-43741787(+) m6A exon//intron       - chr6:43745461-43745462(+) m6A exon//intron       27773535 chr6:43745833-43745834(+) m6A exon//intron       - chr6:43745926-43745927(+) m6A exon//intron       - chr6:43746210-43746211(+) m6A CDS//exon//intron       24284625//24209618 chr6:43746477-43746478(+) m6A exon//intron       24981863 chr6:43746646-43746647(+) m6A CDS//exon//intron       24981863 chr6:43746762-43746763(+) m6A exon//intron       24981863 chr6:43747745-43747746(+) m6A exon//intron       - chr6:43748323-43748324(+) m6A exon//intron       - chr6:43749769-43749770(+) m6A CDS//exon//intron       24284625 chr6:43749775-43749776(+) m6A CDS//exon//intron       24284625 chr6:43752338-43752339(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:43752360-43752361(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr6:43752386-43752387(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr6:43752423-43752424(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr6:43752441-43752442(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43752463-43752464(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43752498-43752499(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:43752632-43752633(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr6:43752790-43752791(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43752852-43752853(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43752961-43752962(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43752971-43752972(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43753013-43753014(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43753021-43753022(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43753022-43753023(+) Cm 3'UTR//exon       - chr6:43753046-43753047(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43753082-43753083(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43753211-43753212(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:43753243-43753244(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:43753288-43753289(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr6:43753339-43753340(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr6:43753362-43753363(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr6:43753387-43753388(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr6:43753464-43753465(+) m6A 3'UTR//exon       24284625//24209618//22575960 chr6:43753562-43753563(+) m6A 3'UTR//exon       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-23b-3p	Apoptotic body Human umbilical vein endothelial cells     19996457 Cytoplasm Cell line (HeLa)     21695135 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Renal cancer cells     21670082 Exosome Ovarian follicular fluid     22116803 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Endothelial cells|Epithelial cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Myotube     27396686 Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Colon adenocarcinoma cells     20864815
	VEGFA	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Endoplasmic reticulum Human fibrosarcoma cells (HT1080)     25753659 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HeLa cells     25063809

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-23b-3p	Arjunolic acid 73641 Drug resistant Phosphotrienin 6913994 Drug resistant Adenosine, 2-bromo-2'-deoxy- 55914 Drug resistant Plumericin 5281545 Drug resistant Jolkinolide B 161954 Drug resistant (1S,3R,7Z,9R,12S,13R,15S)-13-Butan-2-yl-13-hydroxy-3,7,12-trimethyl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 11972510 Drug resistant 6-[4-(1-Cyclohexenyl)-1,3-butadiyn-1-yl]-2(2H)-pyranone 10263039 Drug resistant 2-(1-(2-fluorophenylsulfonyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide - Drug resistant 2-methylellpticinium - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-23b-3p	Curcumin 969516 Drug interaction    RC00002484 Formaldehyde 712 Drug interaction    RC00002465 Medroxyprogesterone acetate 6279 Drug interaction    RC00002473 Alocrest 60780 Drug interaction    RC00002478 Vincristine 5978 Drug interaction    RC00002472 D-Glucose 5793 Drug interaction    RC00002471 Estradiol 5757 Drug interaction    RC00002470 Temozolomide 5394 Drug interaction    RC00002469 Eloxatine 5310940 Drug interaction    RC00002486 Morphine 5288826 Drug interaction    RC00002485 Decitabine 451668 Drug interaction    RC00002483 Trichostatin A 444732 Drug interaction    RC00002482 Cyclopamine 442972 Drug interaction    RC00002481 Etoposide 36462 Drug interaction    RC00002477 Paclitaxel 36314 Drug interaction    RC00002476 5-Fluorouracil 3385 Drug interaction    RC00002468 Doxorubicin 31703 Drug interaction    RC00002475 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002467 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00002487 Bicalutamide 2375 Drug interaction    RC00002466 Arsenic trioxide 14888 Drug interaction    RC00002474 Ginsenoside Rh2 119307 Drug interaction    RC00002480 Bevacizumab - Drug interaction    RC00002488 platinum-based doublet chemotherapy - Drug interaction    RC00002489 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00002490 Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00002491

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-23b-3p	Cisplatin 5702198       25996293 Cisplatin 5702198       29162158 Paclitaxel 36314       26323677 5-Fluorouracil 3385       25996293 5-Fluorouracil 3385       29162158 Doxorubicin 31703       25698578 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124 Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       25996293

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-23b-3p
Interactor2: VEGFA

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA
Support Database	ViRBase

References:

PMID	31985023	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	In the predication analysis, NEAT1 targeted 144 mRNAs through miRNAs (Table III).