Basic Information:

  VIRBase ID:  

HHID00092273

  Virus:  

Influenza A virus (A/Puerto Rico/8/1934(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30a-3p:  MIMAT0000088          RUNX2:  NR_103532     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30a-3p	RUNX2
miRBase Accession/Entrez ID	MIMAT0000088	860
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AML3//CBF-alpha-1//CBFA1//CCD//CCD1//CLCD//OSF-2//OSF2//PEA2aA//PEBP2aA

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30a-3p	rs149150037 chr6:71403567    G/A rs149150037 chr6:71403567    G/C rs370184894 chr6:71403566    C/A rs370184894 chr6:71403566    C/T rs552541514 chr6:71403558    C/G rs745605208 chr6:71403563    ATCCG/A rs746505574 chr6:71403557    G/A rs746505574 chr6:71403557    G/T rs746965145 chr6:71403554    GCT/G rs750918072 chr6:71403564    T/C rs765735953 chr6:71403560    A/T rs770865356 chr6:71403559    A/AC rs776574456 chr6:71403560    A/AAGCTGGAGT rs368070339 chr6:71403571    G/A rs769702885 chr6:71403570    TG/T rs775921090 chr6:71403574    AGCC/A rs781617967 chr6:71403573    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RUNX2	chr6:45348414(+) A-I      intronic chr6:45410988(+) A-I      intronic chr6:45347354(+) A-I      intronic chr6:45433512(+) A-I      intronic chr6:45411010(+) A-I      intronic chr6:45517661(+) A-I      3'UTR chr6:45503194(+) A-I      intronic chr6:45491288(+) A-I      intronic chr6:45493556(+) A-I      intronic chr6:45491282(+) A-I      intronic chr6:45491416(+) A-I      intronic chr6:45347472(+) A-I      intronic chr6:45493470(+) A-I      intronic chr6:45491143(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RUNX2	chr6:45424493(+) A-I intron -    21960545 chr6:45347472(+) A-G intron -    22484847 chr6:45491129(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RUNX2	chr6:45296079-45296080(+) m6A 5'UTR//exon       - chr6:45296090-45296091(+) m6A 5'UTR//exon       - chr6:45296108-45296109(+) m6A 5'UTR//exon       - chr6:45296123-45296124(+) m6A 5'UTR//exon       - chr6:45296184-45296185(+) m6A 5'UTR//exon       - chr6:45389885-45389886(+) m6A 5'UTR//intron       - chr6:45389893-45389894(+) m6A 5'UTR//intron       - chr6:45389915-45389916(+) m6A 5'UTR//intron       25456834 chr6:45389966-45389967(+) m6A 5'UTR//intron       25456834//24981863 chr6:45389985-45389986(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr6:45390013-45390014(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863 chr6:45390060-45390061(+) m6A 5'UTR//intron       24284625//24209618//24981863//27371828 chr6:45390126-45390127(+) m6A 5'UTR//intron       24284625//24209618//24981863//27371828 chr6:45390144-45390145(+) m6A 5'UTR//intron       24284625//24209618//24981863//27371828 chr6:45390171-45390172(+) m6A 5'UTR//intron       24209618 chr6:45390606-45390607(+) m6A CDS//intron       - chr6:45390673-45390674(+) m6A CDS//intron       - chr6:45405771-45405772(+) m6A 3'UTR//CDS       - chr6:45405780-45405781(+) m6A 3'UTR//CDS       - chr6:45459684-45459685(+) m6A 3'UTR//CDS//intron       - chr6:45459705-45459706(+) m6A 3'UTR//CDS//intron       - chr6:45459785-45459786(+) m6A 3'UTR//CDS//intron       - chr6:45459803-45459804(+) m6A 3'UTR//CDS//intron       - chr6:45459834-45459835(+) m6A 3'UTR//CDS//intron       - chr6:45514573-45514574(+) m6A 3'UTR//CDS//intron       - chr6:45514590-45514591(+) m6A 3'UTR//CDS//intron       - chr6:45514780-45514781(+) m6A 3'UTR//CDS//intron       24284625//24209618 chr6:45514790-45514791(+) m6A 3'UTR//CDS//intron       24209618 chr6:45515247-45515248(+) m6A 3'UTR//intron       24209618//24981863 chr6:45515303-45515304(+) m6A 3'UTR//intron       24209618//24981863 chr6:45515388-45515389(+) m6A 3'UTR//intron       24209618//24981863 chr6:45515441-45515442(+) m6A 3'UTR//intron       24209618//25456834//24981863 chr6:45515474-45515475(+) m6A 3'UTR//intron       24209618//25456834//24981863 chr6:45515491-45515492(+) m6A 3'UTR//intron       24209618//25456834//24981863 chr6:45515503-45515504(+) m6A 3'UTR//intron       24209618//25456834//24981863 chr6:45515526-45515527(+) m6A 3'UTR//intron       24209618//25456834//24981863 chr6:45515597-45515598(+) m6A 3'UTR//intron       24209618//24981863 chr6:45515620-45515621(+) m6A 3'UTR//intron       24209618//24981863 chr6:45515741-45515742(+) m6A 3'UTR//intron       24209618 chr6:45515766-45515767(+) m6A 3'UTR//intron       24209618 chr6:45516898-45516899(+) m6A 3'UTR//intron       - chr6:45517017-45517018(+) m6A 3'UTR//intron       - chr6:45517053-45517054(+) m6A 3'UTR//intron       - chr6:45630872-45630873(+) m6A 3'UTR//CDS       24209618 chr6:45631334-45631335(+) m6A 3'UTR//CDS       24209618//25456834 chr6:45631354-45631355(+) m6A 3'UTR//CDS       24209618//25456834 chr6:45631373-45631374(+) m6A 3'UTR//CDS       24209618//25456834 chr6:45631398-45631399(+) m6A 3'UTR//CDS       24209618//25456834 chr6:45631616-45631617(+) m6A 3'UTR       24209618 chr6:45631774-45631775(+) m6A 3'UTR       24209618

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30a-3p	Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Endothelial cells|Epithelial cells|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Serum     24797360 Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	RUNX2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30a-3p	Sorafenib 216239 Drug interaction    RC00000903

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30a-3p	Imatinib 5291       25349971

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30a-3p
Interactor2: RUNX2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA
Support Database	ViRBase

References:

PMID	31985023	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	In the predication analysis, NEAT1 targeted 144 mRNAs through miRNAs (Table III).