Detail Information

Basic Information:


  VIRBase ID:  

HHID00092125

  Virus:  

Influenza A virus (A/Mexico/InDRE4487/2009(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.8847

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1281:           MRAP2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1281 MRAP2
miRBase
Accession/Entrez ID
MIMAT0005939 112609
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - bA51G5.2//C6orf117

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1281
rs1249189883 chr22:41092558    T/TC
rs1329557126 chr22:41092557    C/CT
rs1335249194 chr22:41092555    C/T
rs1404486533 chr22:41092558    T/G
rs367572051 chr22:41092554    C/T
rs753061558 chr22:41092561    C/G
rs753061558 chr22:41092561    C/T
rs767773698 chr22:41092560    C/T
rs894845994 chr22:41092557    C/T
rs1160712735 chr22:41092548    C/T
rs1223934567 chr22:41092549    C/G
rs1321275091 chr22:41092547    G/T
rs540658952 chr22:41092546    C/T
rs751614908 chr22:41092552    C/T
rs762834103 chr22:41092550    T/G
rs766466053 chr22:41092551    C/T
rs903676881 chr22:41092547    GCCT/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MRAP2
chr6:84791309(+) A-I      intronic
chr6:84791306(+) A-I      intronic
chr6:84791283(+) A-I      intronic
chr6:84791282(+) A-I      intronic
chr6:84791280(+) A-I      intronic
chr6:84756349(+) A-I      intronic
chr6:84756313(+) A-I      intronic
chr6:84773541(+) A-I      intronic
chr6:84774413(+) A-I      intronic
chr6:84756353(+) A-I      intronic
chr6:84756245(+) A-I      intronic
chr6:84757154(+) A-I      intronic
chr6:84757185(+) A-I      intronic
chr6:84761399(+) A-I      intronic
chr6:84757176(+) A-I      intronic
chr6:84756323(+) A-I      intronic
chr6:84757110(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MRAP2
chr6:84798961-84798962(+) m6A CDS       25456834//24981863//22608085
chr6:84798984-84798985(+) m6A CDS       25456834//24981863//22608085
chr6:84799057-84799058(+) m6A CDS       25456834//24981863//22608085
chr6:84799093-84799094(+) m6A CDS       25456834//24981863//22608085
chr6:84799099-84799100(+) m6A CDS       25456834//24981863//22608085
chr6:84799105-84799106(+) m6A CDS       25456834//24981863//22608085
chr6:84799139-84799140(+) m6A CDS       25456834//24981863//22608085
chr6:84799158-84799159(+) m6A CDS       25456834//24981863//22608085
chr6:84799176-84799177(+) m6A CDS       25456834//24981863//22608085
chr6:84799189-84799190(+) m6A CDS       25456834//24981863//22608085
chr6:84799203-84799204(+) m6A 3'UTR       25456834//24981863//22608085
chr6:84799302-84799303(+) m6A 3'UTR       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1281
Exosome Pooled sera     27278097
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
MRAP2
Chromatin K562 cells     -
Cytosol K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID
Function Link  
RNAInter hsa-miR-1281
Eloxatine 5310940 Drug interaction    RC00007834
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1281
Paclitaxel       36314

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1281
Interactor2: MRAP2

Evidence Support:


Strong-Evidence qRT-PCR
Weak-Evidence Microarray
Prediction-Evidence miRanda
Support Database ViRBase

References:


PMID 22438559 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line A549 cells Interactor2 expression Downregulation
Description Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1.

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