Basic Information:

  VIRBase ID:  

HHID00092110

  Virus:  

Influenza A virus (A/Mexico/InDRE4487/2009(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.8847

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-138-1-3p:  MIMAT0004607          LGSN:  NM_001143940     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-138-1-3p	LGSN
miRBase Accession/Entrez ID	MIMAT0004607	51557
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GLULD1//LGS

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-138-1-3p	rs1215016527 chr3:44114288    C/T rs759234321 chr3:44114292    G/A rs759234321 chr3:44114292    G/C rs770499543 chr3:44114276    T/C rs773680447 chr3:44114278    C/A rs892673276 chr3:44114281    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LGSN	chr6:63988501(-) A-I      3'UTR chr6:63987879(-) A-I      3'UTR chr6:63987948(-) A-I      3'UTR chr6:63987807(-) A-I      3'UTR chr6:63987949(-) A-I      3'UTR chr6:63988438(-) A-I      3'UTR chr6:63988452(-) A-I      3'UTR chr6:63987892(-) A-I      3'UTR chr6:63987867(-) A-I      3'UTR chr6:63987855(-) A-I      3'UTR chr6:63988556(-) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LGSN	chr6:63986042-63986043(-) m6A 3'UTR       27773535 chr6:63986120-63986121(-) m6A 3'UTR       27773535 chr6:63986125-63986126(-) m6A 3'UTR       27773535 chr6:63986181-63986182(-) m6A 3'UTR       24981863//27773535 chr6:63986269-63986270(-) m6A 3'UTR       27773535 chr6:63986306-63986307(-) m6A 3'UTR       27773535 chr6:63986319-63986320(-) m6A 3'UTR       27773535 chr6:63988381-63988382(-) m6A 3'UTR       24981863 chr6:63988538-63988539(-) Y 3'UTR       26075521 chr6:63989404-63989405(-) m6A 3'UTR//intron       27773535 chr6:63989417-63989418(-) m6A 3'UTR//intron       27773535 chr6:63989494-63989495(-) m6A 3'UTR//intron       24981863//27773535 chr6:63989593-63989594(-) m6A 3'UTR//intron       24981863//27773535 chr6:63989696-63989697(-) m6A 3'UTR//intron       24981863//27773535 chr6:63989733-63989734(-) m6A 3'UTR//intron       24981863//27773535 chr6:63989760-63989761(-) m6A 3'UTR//intron       24981863//27773535 chr6:63989851-63989852(-) m6A 3'UTR//intron       24981863//27773535 chr6:63989856-63989857(-) m6A 3'UTR//intron       24981863//27773535 chr6:63989864-63989865(-) m6A 3'UTR//intron       24981863//27773535 chr6:63989898-63989899(-) m6A 3'UTR//intron       24981863//27773535 chr6:63990020-63990021(-) m6A 3'UTR//CDS//intron       24981863//27773535 chr6:63990036-63990037(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535 chr6:63990081-63990082(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535 chr6:63990102-63990103(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535 chr6:63990118-63990119(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22575960 chr6:63990165-63990166(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22575960 chr6:63990211-63990212(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22575960 chr6:63990231-63990232(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22575960 chr6:63990331-63990332(-) m6A 3'UTR//CDS//intron       24284625//25456834//24981863//27773535 chr6:63990340-63990341(-) m6A 3'UTR//CDS//intron       24284625//25456834//24981863//27773535 chr6:63990414-63990415(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535 chr6:63990455-63990456(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535 chr6:63990478-63990479(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535 chr6:63990539-63990540(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535 chr6:63990596-63990597(-) m6A 3'UTR//CDS//intron       24284625//24981863 chr6:63990962-63990963(-) m6A 3'UTR//CDS       24981863 chr6:63991060-63991061(-) m6A 3'UTR//CDS       24981863//27773535 chr6:63995514-63995515(-) m6A 3'UTR//CDS       27773535 chr6:63995540-63995541(-) m6A 3'UTR//CDS       27773535 chr6:63995590-63995591(-) m6A 3'UTR//CDS       27773535 chr6:63995599-63995600(-) m6A 3'UTR//CDS       27773535 chr6:63995645-63995646(-) m6A CDS//intron       27773535 chr6:64004869-64004870(-) m6A CDS       24981863 chr6:64004889-64004890(-) m6A CDS       24981863 chr6:64004903-64004904(-) m6A CDS       24981863 chr6:64004922-64004923(-) m6A CDS       24981863 chr6:64029831-64029832(-) m6A CDS       24981863 chr6:64029864-64029865(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-138-1-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	LGSN	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-138-1-3p
Interactor2: LGSN

Evidence Support:

Strong-Evidence	qRT-PCR
Weak-Evidence	Microarray
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	22438559	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	A549 cells	Interactor2 expression	Downregulation
Description	Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1.