Detail Information

Basic Information:


  VIRBase ID:  

HHID00092046

  Virus:  

Influenza A virus (A/Mexico/InDRE4487/2009(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.8847

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:           RAD23B:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30d-5p RAD23B
miRBase
Accession/Entrez ID		 MIMAT0000245 5887
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HHR23B//HR23B//P58

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30d-5p
rs1203910650 chr8:134804928    G/A
rs1244539439 chr8:134804930    G/T
rs1441595222 chr8:134804927    C/A
rs1441595222 chr8:134804927    C/T
rs374432132 chr8:134804931    G/A
rs776972352 chr8:134804925    G/A
rs1187386485 chr8:134804934    G/A
rs1373057893 chr8:134804937    TACA/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RAD23B
chr9:110089130(+) A-I      intronic
chr9:110089019(+) A-I      intronic
chr9:110089014(+) A-I      intronic
chr9:110089001(+) A-I      intronic
chr9:110088995(+) A-I      intronic
chr9:110088682(+) A-I      intronic
chr9:110088641(+) A-I      intronic
chr9:110088615(+) A-I      intronic
chr9:110088599(+) A-I      intronic
chr9:110070709(+) A-I      intronic
chr9:110070700(+) A-I      intronic
chr9:110088606(+) A-I      intronic
chr9:110070629(+) A-I      intronic
chr9:110056205(+) A-I      intronic
chr9:110056196(+) A-I      intronic
chr9:110058909(+) A-I      intronic
chr9:110058912(+) A-I      intronic
chr9:110058957(+) A-I      intronic
chr9:110058955(+) A-I      intronic
chr9:110088598(+) A-I      intronic
chr9:110051605(+) A-I      intronic
chr9:110050929(+) A-I      intronic
chr9:110088607(+) A-I      intronic
chr9:110050856(+) A-I      intronic
chr9:110088583(+) A-I      intronic
chr9:110058918(+) A-I      intronic
chr9:110093528(+) A-I      3'UTR
chr9:110093545(+) A-I      3'UTR
chr9:110051545(+) A-I      intronic
chr9:110058896(+) A-I      intronic
chr9:110050827(+) A-I      intronic
chr9:110051514(+) A-I      intronic
chr9:110049209(+) A-I      intronic
chr9:110054707(+) A-I      intronic
chr9:110089182(+) A-I      intronic
chr9:110088572(+) A-I      intronic
chr9:110059682(+) A-I      intronic
chr9:110067443(+) A-I      intronic
chr9:110089101(+) A-I      intronic
chr9:110089060(+) A-I      intronic
chr9:110056182(+) A-I      intronic
chr9:110068122(+) A-I      intronic
chr9:110063913(+) A-I      intronic
chr9:110089044(+) A-I      intronic
chr9:110059318(+) A-I      intronic
chr9:110051583(+) A-I      intronic
chr9:110050866(+) A-I      intronic
chr9:110049258(+) A-I      intronic
chr9:110089016(+) A-I      intronic
chr9:110056134(+) A-I      intronic
chr9:110089126(+) A-I      intronic
chr9:110070604(+) A-I      intronic
chr9:110054782(+) A-I      intronic
chr9:110051519(+) A-I      intronic
chr9:110054882(+) A-I      intronic
chr9:110054911(+) A-I      intronic
chr9:110051672(+) A-I      intronic
chr9:110059278(+) A-I      intronic
chr9:110059090(+) A-I      intronic
chr9:110054807(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED RAD23B
chr9:110056182(+) A-I intron -    21960545
chr9:110088572(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RAD23B
chr9:110045643-110045644(+) m6A 5'UTR//intron       24209618//24981863//27773536//22575960
chr9:110045851-110045852(+) m6A 5'UTR       24209618//24981863//27773536//22575960
chr9:110045928-110045929(+) m6A CDS       24209618//24981863//26404942//22575960
chr9:110045943-110045944(+) m6A CDS       24209618//24981863//26404942//22575960
chr9:110045956-110045957(+) m6A CDS       24209618//24981863//26404942
chr9:110058395-110058396(+) Tm intron       -
chr9:110068838-110068839(+) m6A CDS       24981863//26404942//22575960
chr9:110068862-110068863(+) m6A CDS       24981863//22575960
chr9:110086219-110086220(+) m6A CDS//intron       27773535
chr9:110087158-110087159(+) m6A CDS//intron       24981863//26404942//27773535
chr9:110087241-110087242(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:110091849-110091850(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:110091920-110091921(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:110091942-110091943(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr9:110092581-110092582(+) m6A 3'UTR//intron       27773535
chr9:110093029-110093030(+) m6A 3'UTR//intron       27773535
chr9:110093034-110093035(+) m6A 3'UTR//intron       27773535
chr9:110093068-110093069(+) m6A 3'UTR//intron       27773535
chr9:110093498-110093499(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr9:110093584-110093585(+) m6A 3'UTR//intron       24284625//24209618//22608085
chr9:110093607-110093608(+) m6A 3'UTR//intron       24284625//24209618//24981863//22608085
chr9:110093704-110093705(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085
chr9:110093753-110093754(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085
chr9:110093770-110093771(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085
chr9:110093961-110093962(+) m6A 3'UTR//CDS       24284625//24981863//22608085
chr9:110093968-110093969(+) m6A 3'UTR//CDS       24284625//24981863//22608085
chr9:110093981-110093982(+) m6A 3'UTR//CDS       24284625//24981863//22608085
chr9:110094036-110094037(+) m6A 3'UTR       24284625//24981863//22608085
chr9:110094074-110094075(+) m6A 3'UTR       24284625//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30d-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome HCC tissues     30542726
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Cerebrospinal fluid     25420022
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
RAD23B
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-30d-5p
Midostaurin 9829523 Drug resistant
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive
Kinetin riboside 20345 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
Cladospirone bisepoxide 10316810 Drug sensitive
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
antineoplastic-d655481 - Drug resistant
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
isatin dr - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30d-5p
Gemcitabine 60750 Drug interaction    RC00001621
Sunitinib 5329102 Drug interaction    RC00001626
Eloxatine 5310940 Drug interaction    RC00001625
Trichostatin A 444732 Drug interaction    RC00001624
Paroxetine 43815 Drug interaction    RC00001620
Etoposide 36462 Drug interaction    RC00001619
5-Fluorouracil 3385 Drug interaction    RC00001617
Doxorubicin 31703 Drug interaction    RC00001618
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616
Verapamil 2520 Drug interaction    RC00001615
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627
Bicalutamide 2375 Drug interaction    RC00001614
Docetaxel 148124 Drug interaction    RC00001623
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628
Trastuzumab - Drug interaction    RC00001629
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30d-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30d-5p
Interactor2: RAD23B

Evidence Support:


Strong-Evidence qRT-PCR
Weak-Evidence Microarray
Prediction-Evidence miRanda
Support Database ViRBase

References:


PMID 22438559 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line A549 cells Interactor2 expression Upregulation
Description Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1.

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