Basic Information:

  VIRBase ID:  

HHID00092045

  Virus:  

Influenza A virus (A/Mexico/InDRE4487/2009(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.8847

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:  MIMAT0000245          KIF11:  NM_004523     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30d-5p	KIF11
miRBase Accession/Entrez ID	MIMAT0000245	3832
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	EG5//HKSP//KNSL1//MCLMR//TRIP5

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30d-5p	rs1203910650 chr8:134804928    G/A rs1244539439 chr8:134804930    G/T rs1441595222 chr8:134804927    C/A rs1441595222 chr8:134804927    C/T rs374432132 chr8:134804931    G/A rs776972352 chr8:134804925    G/A rs1187386485 chr8:134804934    G/A rs1373057893 chr8:134804937    TACA/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KIF11	chr10:94396604(+) A-I      intronic chr10:94396603(+) A-I      intronic chr10:94396594(+) A-I      intronic chr10:94396580(+) A-I      intronic chr10:94373668(+) A-I      intronic chr10:94378147(+) A-I      intronic chr10:94393815(+) A-I      intronic chr10:94396534(+) A-I      intronic chr10:94394259(+) A-I      intronic chr10:94377758(+) A-I      intronic chr10:94381488(+) A-I      intronic chr10:94374906(+) A-I      intronic chr10:94381549(+) A-I      intronic chr10:94384774(+) A-I      intronic chr10:94359539(+) A-I      intronic chr10:94377547(+) A-I      intronic chr10:94381444(+) A-I      intronic chr10:94378353(+) A-I      intronic chr10:94386726(+) A-I      intronic chr10:94386787(+) A-I      intronic chr10:94377638(+) A-I      intronic chr10:94358664(+) A-I      intronic chr10:94358725(+) A-I      intronic chr10:94359072(+) A-I      intronic chr10:94390439(+) A-I      intronic chr10:94359161(+) A-I      intronic chr10:94359490(+) A-I      intronic chr10:94390545(+) A-I      intronic chr10:94390574(+) A-I      intronic chr10:94390581(+) A-I      intronic chr10:94359513(+) A-I      intronic chr10:94359843(+) A-I      intronic chr10:94368249(+) A-I      intronic chr10:94371455(+) A-I      intronic chr10:94390765(+) A-I      intronic chr10:94390864(+) A-I      intronic chr10:94371479(+) A-I      intronic chr10:94373571(+) A-I      intronic chr10:94390928(+) A-I      intronic chr10:94390957(+) A-I      intronic chr10:94373579(+) A-I      intronic chr10:94373583(+) A-I      intronic chr10:94374051(+) A-I      intronic chr10:94390958(+) A-I      intronic chr10:94374599(+) A-I      intronic chr10:94374816(+) A-I      intronic chr10:94391666(+) A-I      intronic chr10:94374833(+) A-I      intronic chr10:94376055(+) A-I      intronic chr10:94391946(+) A-I      intronic chr10:94392018(+) A-I      intronic chr10:94377652(+) A-I      intronic chr10:94392028(+) A-I      intronic chr10:94392067(+) A-I      intronic chr10:94392086(+) A-I      intronic chr10:94393820(+) A-I      intronic chr10:94378152(+) A-I      intronic chr10:94371469(+) A-I      intronic chr10:94374686(+) A-I      intronic chr10:94393821(+) A-I      intronic chr10:94393870(+) A-I      intronic chr10:94390539(+) A-I      intronic chr10:94407786(+) A-I      intronic chr10:94393947(+) A-I      intronic chr10:94378238(+) A-I      intronic chr10:94396173(+) A-I      intronic chr10:94396252(+) A-I      intronic chr10:94358604(+) A-I      intronic chr10:94396258(+) A-I      intronic chr10:94396279(+) A-I      intronic chr10:94396285(+) A-I      intronic chr10:94394251(+) A-I      intronic chr10:94371454(+) A-I      intronic chr10:94358598(+) A-I      intronic chr10:94396298(+) A-I      intronic chr10:94396253(+) A-I      intronic chr10:94389475(+) A-I      intronic chr10:94396314(+) A-I      intronic chr10:94396318(+) A-I      intronic chr10:94396670(+) A-I      intronic chr10:94376140(+) A-I      intronic chr10:94377747(+) A-I      intronic chr10:94381420(+) A-I      intronic chr10:94396696(+) A-I      intronic chr10:94372065(+) A-I      intronic chr10:94371176(+) A-I      intronic chr10:94376067(+) A-I      intronic chr10:94377577(+) A-I      intronic chr10:94359105(+) A-I      intronic chr10:94396188(+) A-I      intronic chr10:94377662(+) A-I      intronic chr10:94373586(+) A-I      intronic chr10:94396164(+) A-I      intronic chr10:94391652(+) A-I      intronic chr10:94381422(+) A-I      intronic chr10:94374122(+) A-I      intronic chr10:94381383(+) A-I      intronic chr10:94359171(+) A-I      intronic chr10:94374677(+) A-I      intronic chr10:94371536(+) A-I      intronic chr10:94394252(+) A-I      intronic chr10:94373479(+) A-I      intronic chr10:94373576(+) A-I      intronic chr10:94396715(+) A-I      intronic chr10:94376084(+) A-I      intronic chr10:94396239(+) A-I      intronic chr10:94381920(+) A-I      intronic chr10:94371581(+) A-I      intronic chr10:94379967(+) A-I      intronic chr10:94396187(+) A-I      intronic chr10:94357305(+) A-I      intronic chr10:94396219(+) A-I      intronic chr10:94390369(+) A-I      intronic chr10:94381436(+) A-I      intronic chr10:94375049(+) A-I      intronic chr10:94378220(+) A-I      intronic chr10:94378296(+) A-I      intronic chr10:94359106(+) A-I      intronic chr10:94360547(+) A-I      intronic chr10:94373940(+) A-I      intronic chr10:94371470(+) A-I      intronic chr10:94391502(+) A-I      intronic chr10:94368376(+) A-I      intronic chr10:94374594(+) A-I      intronic chr10:94373502(+) A-I      intronic chr10:94390367(+) A-I      intronic chr10:94390438(+) A-I      intronic chr10:94392054(+) A-I      intronic chr10:94390370(+) A-I      intronic chr10:94396322(+) A-I      intronic chr10:94373954(+) A-I      intronic chr10:94358599(+) A-I      intronic chr10:94377646(+) A-I      intronic chr10:94381459(+) A-I      intronic chr10:94360743(+) A-I      intronic chr10:94373652(+) A-I      intronic chr10:94394127(+) A-I      intronic chr10:94394166(+) A-I      intronic chr10:94359012(+) A-I      intronic chr10:94394214(+) A-I      intronic chr10:94373567(+) A-I      intronic chr10:94391615(+) A-I      intronic chr10:94359081(+) A-I      intronic chr10:94378272(+) A-I      intronic chr10:94378266(+) A-I      intronic chr10:94375043(+) A-I      intronic chr10:94371591(+) A-I      intronic chr10:94390410(+) A-I      intronic chr10:94394168(+) A-I      intronic chr10:94393880(+) A-I      intronic chr10:94381382(+) A-I      intronic chr10:94371406(+) A-I      intronic chr10:94378283(+) A-I      intronic chr10:94358634(+) A-I      intronic chr10:94371535(+) A-I      intronic chr10:94378146(+) A-I      intronic chr10:94371417(+) A-I      intronic chr10:94377571(+) A-I      intronic chr10:94396535(+) A-I      intronic chr10:94378195(+) A-I      intronic chr10:94374034(+) A-I      intronic chr10:94377697(+) A-I      intronic chr10:94373665(+) A-I      intronic chr10:94381458(+) A-I      intronic chr10:94359100(+) A-I      intronic chr10:94376143(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	KIF11	chr10:94378220(+) A-G intron -    22484847 chr10:94378272(+) A-G intron -    22484847 chr10:94378283(+) A-G intron -    22484847 chr10:94396187(+) A-G intron -    22484847 chr10:94396188(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KIF11	chr10:94353126-94353127(+) m6A 5'UTR       24981863 chr10:94353184-94353185(+) m6A CDS       24981863 chr10:94372866-94372867(+) Am CDS       - chr10:94376564-94376565(+) m6A CDS       24981863 chr10:94389964-94389965(+) m6A CDS       24981863 chr10:94389998-94389999(+) m6A CDS       24981863 chr10:94390006-94390007(+) m6A CDS       24981863 chr10:94390013-94390014(+) m6A CDS       24981863 chr10:94390024-94390025(+) m6A CDS       24981863 chr10:94390037-94390038(+) m6A CDS       24981863 chr10:94390099-94390100(+) m6A CDS       24981863 chr10:94397258-94397259(+) m6A CDS       22575960 chr10:94397270-94397271(+) m6A CDS       22575960 chr10:94397278-94397279(+) m6A CDS       22575960 chr10:94397290-94397291(+) m6A CDS       22575960 chr10:94405197-94405198(+) m6A CDS       24981863//22608085 chr10:94405248-94405249(+) m6A CDS       24981863//22608085 chr10:94405260-94405261(+) m6A CDS       24981863//22608085 chr10:94405294-94405295(+) m6A CDS       24981863//22608085 chr10:94405299-94405300(+) m6A CDS       24981863//22608085 chr10:94405319-94405320(+) m6A CDS       24981863//22608085 chr10:94405327-94405328(+) m6A CDS       24981863//22608085 chr10:94405344-94405345(+) m6A CDS       24981863//22608085 chr10:94405374-94405375(+) m6A CDS       22608085 chr10:94405380-94405381(+) m6A CDS       22608085 chr10:94413443-94413444(+) m6A CDS       27773535 chr10:94413452-94413453(+) m6A CDS       27773535 chr10:94413493-94413494(+) m6A CDS       27773535 chr10:94413589-94413590(+) m6A 3'UTR       24981863 chr10:94413602-94413603(+) m6A 3'UTR       24981863 chr10:94413609-94413610(+) m6A 3'UTR       24981863 chr10:94413617-94413618(+) m6A 3'UTR       24981863 chr10:94413741-94413742(+) m6A 3'UTR       24981863 chr10:94413764-94413765(+) m6A 3'UTR       24981863 chr10:94413853-94413854(+) m6A 3'UTR       - chr10:94413921-94413922(+) m6A 3'UTR       24981863 chr10:94413935-94413936(+) m6A 3'UTR       24981863 chr10:94414273-94414274(+) m6A 3'UTR       24981863 chr10:94414329-94414330(+) m6A 3'UTR       24981863//27773535 chr10:94414941-94414942(+) m6A 3'UTR       27773535 chr10:94414967-94414968(+) m6A 3'UTR       27773535 chr10:94414972-94414973(+) m6A 3'UTR       27773535 chr10:94415009-94415010(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30d-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome HCC tissues     30542726 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Cerebrospinal fluid     25420022 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	KIF11	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-30d-5p	Midostaurin 9829523 Drug resistant Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive 2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Antimycin A3 245869 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive 4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive Kinetin riboside 20345 Drug resistant Astrazon Orange R 135747272 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive (3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive antineoplastic-d655481 - Drug resistant 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isatin dr - Drug sensitive tetra(isobutenyl)antimony bromide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30d-5p	Gemcitabine 60750 Drug interaction    RC00001621 Sunitinib 5329102 Drug interaction    RC00001626 Eloxatine 5310940 Drug interaction    RC00001625 Trichostatin A 444732 Drug interaction    RC00001624 Paroxetine 43815 Drug interaction    RC00001620 Etoposide 36462 Drug interaction    RC00001619 5-Fluorouracil 3385 Drug interaction    RC00001617 Doxorubicin 31703 Drug interaction    RC00001618 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616 Verapamil 2520 Drug interaction    RC00001615 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627 Bicalutamide 2375 Drug interaction    RC00001614 Docetaxel 148124 Drug interaction    RC00001623 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628 Trastuzumab - Drug interaction    RC00001629

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30d-5p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30d-5p
Interactor2: KIF11

Evidence Support:

Strong-Evidence	qRT-PCR
Weak-Evidence	Microarray
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	22438559	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	A549 cells	Interactor2 expression	Upregulation
Description	Fig 3 The 8-hpi network shows a number of deregulated miRNAs and their predicted targets, including miR-766, that is consistently upregulated throughout infection with H1N1.