Basic Information:

  VIRBase ID:  

HHID00091980

  Virus:  

Influenza A virus (A/California/07/2009(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-125a-5p:  MIMAT0000443          MYL9:  NM_006097     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-125a-5p	MYL9
miRBase Accession/Entrez ID	MIMAT0000443	10398
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	LC20//MLC-2C//MLC2//MRLC1//MYRL2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-125a-5p	rs755486470 chr19:51693290    G/A rs12975333 chr19:51693275    G/T rs1384918474 chr19:51693273    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MYL9	chr20:35175750(+) A-I      intronic chr20:35173712(+) A-I      intronic chr20:35174056(+) A-I      intronic chr20:35175752(+) A-I      intronic chr20:35175759(+) A-I      intronic chr20:35175760(+) A-I      intronic chr20:35175764(+) A-I      intronic chr20:35175768(+) A-I      intronic chr20:35175772(+) A-I      intronic chr20:35175773(+) A-I      intronic chr20:35175782(+) A-I      intronic chr20:35175807(+) A-I      intronic chr20:35175810(+) A-I      intronic chr20:35175315(+) A-I      intronic chr20:35175811(+) A-I      intronic chr20:35176024(+) A-I      intronic chr20:35176036(+) A-I      intronic chr20:35175763(+) A-I      intronic chr20:35176045(+) A-I      intronic chr20:35176046(+) A-I      intronic chr20:35176050(+) A-I      intronic chr20:35174037(+) A-I      intronic chr20:35175739(+) A-I      intronic chr20:35175730(+) A-I      intronic chr20:35175731(+) A-I      intronic chr20:35175735(+) A-I      intronic chr20:35175740(+) A-I      intronic chr20:35173700(+) A-I      intronic chr20:35175271(+) A-I      intronic chr20:35175112(+) A-I      intronic chr20:35175074(+) A-I      intronic chr20:35175061(+) A-I      intronic chr20:35175039(+) A-I      intronic chr20:35174219(+) A-I      intronic chr20:35174148(+) A-I      intronic chr20:35174146(+) A-I      intronic chr20:35174084(+) A-I      intronic chr20:35175744(+) A-I      intronic chr20:35175106(+) A-I      intronic chr20:35175093(+) A-I      intronic chr20:35175087(+) A-I      intronic chr20:35175049(+) A-I      intronic chr20:35175043(+) A-I      intronic chr20:35175042(+) A-I      intronic chr20:35175037(+) A-I      intronic chr20:35174310(+) A-I      intronic chr20:35174273(+) A-I      intronic chr20:35174251(+) A-I      intronic chr20:35174244(+) A-I      intronic chr20:35174243(+) A-I      intronic chr20:35174212(+) A-I      intronic chr20:35174172(+) A-I      intronic chr20:35174171(+) A-I      intronic chr20:35174167(+) A-I      intronic chr20:35174155(+) A-I      intronic chr20:35175113(+) A-I      intronic chr20:35173651(+) A-I      intronic chr20:35173654(+) A-I      intronic chr20:35173715(+) A-I      intronic chr20:35173721(+) A-I      intronic chr20:35173722(+) A-I      intronic chr20:35173723(+) A-I      intronic chr20:35173734(+) A-I      intronic chr20:35173737(+) A-I      intronic chr20:35173738(+) A-I      intronic chr20:35173741(+) A-I      intronic chr20:35173743(+) A-I      intronic chr20:35173747(+) A-I      intronic chr20:35173748(+) A-I      intronic chr20:35173749(+) A-I      intronic chr20:35173750(+) A-I      intronic chr20:35173758(+) A-I      intronic chr20:35173789(+) A-I      intronic chr20:35173806(+) A-I      intronic chr20:35175274(+) A-I      intronic chr20:35175290(+) A-I      intronic chr20:35175287(+) A-I      intronic chr20:35175276(+) A-I      intronic chr20:35173740(+) A-I      intronic chr20:35174087(+) A-I      intronic chr20:35173820(+) A-I      intronic chr20:35173828(+) A-I      intronic chr20:35173895(+) A-I      intronic chr20:35174070(+) A-I      intronic chr20:35175265(+) A-I      intronic chr20:35175262(+) A-I      intronic chr20:35175261(+) A-I      intronic chr20:35175233(+) A-I      intronic chr20:35175222(+) A-I      intronic chr20:35175202(+) A-I      intronic chr20:35175187(+) A-I      intronic chr20:35175179(+) A-I      intronic chr20:35175178(+) A-I      intronic chr20:35175154(+) A-I      intronic chr20:35175130(+) A-I      intronic chr20:35175115(+) A-I      intronic chr20:35174079(+) A-I      intronic chr20:35174180(+) A-I      intronic chr20:35174272(+) A-I      intronic chr20:35174181(+) A-I      intronic chr20:35174156(+) A-I      intronic chr20:35174173(+) A-I      intronic chr20:35173713(+) A-I      intronic chr20:35174078(+) A-I      intronic chr20:35173753(+) A-I      intronic chr20:35174179(+) A-I      intronic chr20:35174170(+) A-I      intronic chr20:35174185(+) A-I      intronic chr20:35173821(+) A-I      intronic chr20:35174182(+) A-I      intronic chr20:35174176(+) A-I      intronic chr20:35175165(+) A-I      intronic chr20:35175142(+) A-I      intronic chr20:35175196(+) A-I      intronic chr20:35173637(+) A-I      intronic chr20:35173646(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MYL9	chr20:35170667(+) A-I intron -    15342557 chr20:35173637(+) A-I intron -    15258596 chr20:35173645(+) A-I intron -    15342557   //15258596 chr20:35173646(+) A-I intron -    15342557   //15258596 chr20:35173667(+) A-I intron -    15258596 chr20:35173713(+) A-I intron -    15342557   //15258596 chr20:35173753(+) A-I intron -    15342557 chr20:35173779(+) A-I intron -    15342557 chr20:35173785(+) A-I intron -    15342557 chr20:35173821(+) A-I intron -    15342557 chr20:35175142(+) A-I intron -    15258596 chr20:35175152(+) A-I intron -    15258596 chr20:35175165(+) A-I intron -    15258596 chr20:35175193(+) A-I intron -    15258596 chr20:35175196(+) A-I intron -    15258596 chr20:35175213(+) A-I intron -    15258596 chr20:35175283(+) A-I intron -    15258596

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MYL9	chr20:35169905-35169906(+) m6A 5'UTR       24284625//25456834//24981863 chr20:35173314-35173315(+) m6A CDS       24284625//25456834//24981863//22575960 chr20:35173417-35173418(+) m6A CDS       24284625//24981863//22575960 chr20:35173444-35173445(+) m6A CDS       24284625//24981863 chr20:35176440-35176441(+) m6A CDS//intron       24284625 chr20:35177791-35177792(+) m6A 3'UTR       24284625//22575960 chr20:35177884-35177885(+) m6A 3'UTR       24284625//25456834//22575960 chr20:35177898-35177899(+) m6A 3'UTR       24284625//25456834//22575960 chr20:35177917-35177918(+) m6A 3'UTR       24284625//25456834//22575960 chr20:35178025-35178026(+) m6A 3'UTR       24284625//25456834//22575960 chr20:35178176-35178177(+) m6A 3'UTR       24284625//24981863//22575960 chr20:35178213-35178214(+) m6A 3'UTR       24284625//24981863 chr20:35179578-35179579(+) m6A 3'UTR       - chr20:35179604-35179605(+) m6A 3'UTR       - chr20:35179672-35179673(+) m6A 3'UTR       - chr20:35179689-35179690(+) m6A 3'UTR       - chr20:35179703-35179704(+) m6A 3'UTR       - chr20:35179712-35179713(+) m6A 3'UTR       - chr20:35179733-35179734(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-125a-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Renal cancer cells     21670082 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Blood|Breast milk|Endothelial cells|Epithelial cells|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Hepatoma cells     23771658 Microvesicle Serum     24797360 Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Myotube     27396686 Mitochondrion Skeletal muscle cells     27563705 Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus HeLa cells     23940654 Nucleolus Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	MYL9	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-125a-5p	Curcumin 969516 Drug interaction    RC00003034 Hyaluronidase 91820602 Drug interaction    RC00003036 Gemcitabine 60750 Drug interaction    RC00003029 Vincristine 5978 Drug interaction    RC00003024 Imatinib 5291 Drug interaction    RC00003023 Decitabine 451668 Drug interaction    RC00003033 Epirubicin 41867 Drug interaction    RC00003028 Paclitaxel 36314 Drug interaction    RC00003027 5-Fluorouracil 3385 Drug interaction    RC00003022 Doxorubicin 31703 Drug interaction    RC00003026 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003021 Tamoxifen 2733526 Drug interaction    RC00003035 Arsenic trioxide 14888 Drug interaction    RC00003025 Docetaxel 148124 Drug interaction    RC00003032 Gefitinib 123631 Drug interaction    RC00003031 Trastuzumab - Drug interaction    RC00003037 Glucocorticoid - Drug interaction    RC00003038 Marine fungal metabolite 1386A - Drug interaction    RC00003039

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-125a-5p	Cisplatin 5702198       25356050 Cisplatin 5702198       29767234 Imatinib 5291       25349971 Imatinib 5291       30249101 5-Fluorouracil 3385       25356050 Doxorubicin 31703       24759738 Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       24759738 Cetuximab -       26107137

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-125a-5p	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Sorafenib       216239 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Dovitinib       135398510 Crizotinib       11626560 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-125a-5p
Interactor2: MYL9

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	microRNA.org//PITA//Targetscan
Support Database	ViRBase

References:

PMID	29059211	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVECs	Interactor2 expression	None
Description	The differential miRNAs and their target genes in the above pathways were concluded in Table S1 and Table S2.