Basic Information:

  VIRBase ID:  

HHID00091968

  Virus:  

Influenza A virus (A/California/07/2009(H1N1))

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-212-3p:  MIMAT0000269          MYL9:  NM_006097     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-212-3p	MYL9
miRBase Accession/Entrez ID	MIMAT0000269	10398
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	LC20//MLC-2C//MLC2//MRLC1//MYRL2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-212-3p	rs1159612457 chr17:2050291    G/A rs1376681081 chr17:2050294    G/C rs1469423347 chr17:2050302    A/T rs771129305 chr17:2050292    C/T rs1260414176 chr17:2050309    T/TA rs1434342640 chr17:2050307    G/C rs756181076 chr17:2050305    CTG/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MYL9	chr20:35175750(+) A-I      intronic chr20:35173712(+) A-I      intronic chr20:35174056(+) A-I      intronic chr20:35175752(+) A-I      intronic chr20:35175759(+) A-I      intronic chr20:35175760(+) A-I      intronic chr20:35175764(+) A-I      intronic chr20:35175768(+) A-I      intronic chr20:35175772(+) A-I      intronic chr20:35175773(+) A-I      intronic chr20:35175782(+) A-I      intronic chr20:35175807(+) A-I      intronic chr20:35175810(+) A-I      intronic chr20:35175315(+) A-I      intronic chr20:35175811(+) A-I      intronic chr20:35176024(+) A-I      intronic chr20:35176036(+) A-I      intronic chr20:35175763(+) A-I      intronic chr20:35176045(+) A-I      intronic chr20:35176046(+) A-I      intronic chr20:35176050(+) A-I      intronic chr20:35174037(+) A-I      intronic chr20:35175739(+) A-I      intronic chr20:35175730(+) A-I      intronic chr20:35175731(+) A-I      intronic chr20:35175735(+) A-I      intronic chr20:35175740(+) A-I      intronic chr20:35173700(+) A-I      intronic chr20:35175271(+) A-I      intronic chr20:35175112(+) A-I      intronic chr20:35175074(+) A-I      intronic chr20:35175061(+) A-I      intronic chr20:35175039(+) A-I      intronic chr20:35174219(+) A-I      intronic chr20:35174148(+) A-I      intronic chr20:35174146(+) A-I      intronic chr20:35174084(+) A-I      intronic chr20:35175744(+) A-I      intronic chr20:35175106(+) A-I      intronic chr20:35175093(+) A-I      intronic chr20:35175087(+) A-I      intronic chr20:35175049(+) A-I      intronic chr20:35175043(+) A-I      intronic chr20:35175042(+) A-I      intronic chr20:35175037(+) A-I      intronic chr20:35174310(+) A-I      intronic chr20:35174273(+) A-I      intronic chr20:35174251(+) A-I      intronic chr20:35174244(+) A-I      intronic chr20:35174243(+) A-I      intronic chr20:35174212(+) A-I      intronic chr20:35174172(+) A-I      intronic chr20:35174171(+) A-I      intronic chr20:35174167(+) A-I      intronic chr20:35174155(+) A-I      intronic chr20:35175113(+) A-I      intronic chr20:35173651(+) A-I      intronic chr20:35173654(+) A-I      intronic chr20:35173715(+) A-I      intronic chr20:35173721(+) A-I      intronic chr20:35173722(+) A-I      intronic chr20:35173723(+) A-I      intronic chr20:35173734(+) A-I      intronic chr20:35173737(+) A-I      intronic chr20:35173738(+) A-I      intronic chr20:35173741(+) A-I      intronic chr20:35173743(+) A-I      intronic chr20:35173747(+) A-I      intronic chr20:35173748(+) A-I      intronic chr20:35173749(+) A-I      intronic chr20:35173750(+) A-I      intronic chr20:35173758(+) A-I      intronic chr20:35173789(+) A-I      intronic chr20:35173806(+) A-I      intronic chr20:35175274(+) A-I      intronic chr20:35175290(+) A-I      intronic chr20:35175287(+) A-I      intronic chr20:35175276(+) A-I      intronic chr20:35173740(+) A-I      intronic chr20:35174087(+) A-I      intronic chr20:35173820(+) A-I      intronic chr20:35173828(+) A-I      intronic chr20:35173895(+) A-I      intronic chr20:35174070(+) A-I      intronic chr20:35175265(+) A-I      intronic chr20:35175262(+) A-I      intronic chr20:35175261(+) A-I      intronic chr20:35175233(+) A-I      intronic chr20:35175222(+) A-I      intronic chr20:35175202(+) A-I      intronic chr20:35175187(+) A-I      intronic chr20:35175179(+) A-I      intronic chr20:35175178(+) A-I      intronic chr20:35175154(+) A-I      intronic chr20:35175130(+) A-I      intronic chr20:35175115(+) A-I      intronic chr20:35174079(+) A-I      intronic chr20:35174180(+) A-I      intronic chr20:35174272(+) A-I      intronic chr20:35174181(+) A-I      intronic chr20:35174156(+) A-I      intronic chr20:35174173(+) A-I      intronic chr20:35173713(+) A-I      intronic chr20:35174078(+) A-I      intronic chr20:35173753(+) A-I      intronic chr20:35174179(+) A-I      intronic chr20:35174170(+) A-I      intronic chr20:35174185(+) A-I      intronic chr20:35173821(+) A-I      intronic chr20:35174182(+) A-I      intronic chr20:35174176(+) A-I      intronic chr20:35175165(+) A-I      intronic chr20:35175142(+) A-I      intronic chr20:35175196(+) A-I      intronic chr20:35173637(+) A-I      intronic chr20:35173646(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MYL9	chr20:35170667(+) A-I intron -    15342557 chr20:35173637(+) A-I intron -    15258596 chr20:35173645(+) A-I intron -    15342557   //15258596 chr20:35173646(+) A-I intron -    15342557   //15258596 chr20:35173667(+) A-I intron -    15258596 chr20:35173713(+) A-I intron -    15342557   //15258596 chr20:35173753(+) A-I intron -    15342557 chr20:35173779(+) A-I intron -    15342557 chr20:35173785(+) A-I intron -    15342557 chr20:35173821(+) A-I intron -    15342557 chr20:35175142(+) A-I intron -    15258596 chr20:35175152(+) A-I intron -    15258596 chr20:35175165(+) A-I intron -    15258596 chr20:35175193(+) A-I intron -    15258596 chr20:35175196(+) A-I intron -    15258596 chr20:35175213(+) A-I intron -    15258596 chr20:35175283(+) A-I intron -    15258596

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MYL9	chr20:35169905-35169906(+) m6A 5'UTR       24284625//25456834//24981863 chr20:35173314-35173315(+) m6A CDS       24284625//25456834//24981863//22575960 chr20:35173417-35173418(+) m6A CDS       24284625//24981863//22575960 chr20:35173444-35173445(+) m6A CDS       24284625//24981863 chr20:35176440-35176441(+) m6A CDS//intron       24284625 chr20:35177791-35177792(+) m6A 3'UTR       24284625//22575960 chr20:35177884-35177885(+) m6A 3'UTR       24284625//25456834//22575960 chr20:35177898-35177899(+) m6A 3'UTR       24284625//25456834//22575960 chr20:35177917-35177918(+) m6A 3'UTR       24284625//25456834//22575960 chr20:35178025-35178026(+) m6A 3'UTR       24284625//25456834//22575960 chr20:35178176-35178177(+) m6A 3'UTR       24284625//24981863//22575960 chr20:35178213-35178214(+) m6A 3'UTR       24284625//24981863 chr20:35179578-35179579(+) m6A 3'UTR       - chr20:35179604-35179605(+) m6A 3'UTR       - chr20:35179672-35179673(+) m6A 3'UTR       - chr20:35179689-35179690(+) m6A 3'UTR       - chr20:35179703-35179704(+) m6A 3'UTR       - chr20:35179712-35179713(+) m6A 3'UTR       - chr20:35179733-35179734(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-212-3p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Plasma     19289371 Exosome Saliva     19627513 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Follicular fluid     23666971 Microvesicle Cerebrospinal fluid     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	MYL9	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-212-3p	Rachelmycin 9939943 Drug sensitive 2-(2,4-Difluorophenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione 9905583 Drug sensitive Saintopin E 9864639 Drug sensitive Hedamycin 98033 Drug sensitive Tetraethyleniminobenzo-quinone 95735 Drug sensitive 2,4,7-Triamino-6-o-tolylpteridine 95122 Drug sensitive o-Aminoazotoluene 7340 Drug sensitive 10,11-Methylenedioxy-20S-camptothecin 72403 Drug sensitive Mitozolomide 71766 Drug sensitive Anaxirone 71218 Drug sensitive Antineoplastic-301477 6711219 Drug sensitive Baker's Antifol 64840 Drug sensitive Mevastatin 64715 Drug sensitive 1,3,8-Trihydroxy-6-methoxyanthracene-9,10-dione 636723 Drug resistant Cytarabine 6253 Drug sensitive Irinotecan 60838 Drug sensitive Bizelesin 60794 Drug sensitive Topotecan 60700 Drug sensitive Triethylenemelamine 5799 Drug sensitive Floxuridine 5790 Drug sensitive Mitomycin 5746 Drug sensitive Teclothiazide potassium 56841138 Drug sensitive Antineoplastic-690266 5469577 Drug sensitive Biantrazole 54607781 Drug sensitive Betuletol 5459196 Drug sensitive MX2 hydrochloride 5351347 Drug sensitive Lovastatin 53232 Drug sensitive Streptonigrin 5298 Drug sensitive Improsulfan hydrochloride 5284401 Drug sensitive 5-Fluoro-2'-deoxycytidine 515328 Drug sensitive Methoxycamptothecin 494089 Drug sensitive Dioxadet 48858 Drug sensitive Epidoxoform 46877760 Drug sensitive Melphalan 460612 Drug sensitive Aclarubicin 451415 Drug sensitive 5-Fluoro-2'-deoxyuridyly-(3'->5')-3'-C-ethynylcytosine 45028394 Drug sensitive Mycophenolic acid 446541 Drug sensitive Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide 42640 Drug sensitive Mitoxantrone 4212 Drug sensitive Chelocardin dodecyl sulfate 415844 Drug sensitive 1,3,5-Triazine-2,4-diamine, 1-(3-bromophenyl)-1,6-dihydro-6,6-dimethyl- 407235 Drug sensitive Fagaronine chloride 40304 Drug sensitive Sjg-136 393111 Drug sensitive Salvilenone 389885 Drug resistant Antineoplastic-D648114 372647 Drug sensitive Sanguilutine pseudobase 371258 Drug sensitive 1,2-Dimethyl-phenothiazone 369387 Drug sensitive Diselenide, bis(4-methylphenyl) 365239 Drug sensitive Dolastatin 11 354399 Drug sensitive 2,4-Quinazolinediamine, 6-[[4-(dimethylamino)phenyl]thio]- 328145 Drug sensitive Pinafide 327045 Drug sensitive 5-Cinnamylidene-1,3-thiazolidine-2,4-dione 315044 Drug sensitive Cytosine arabinoside monophosphate 314 Drug sensitive 2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug sensitive Daunorubicin 30323 Drug sensitive Dichloroallyl lawsone 277767 Drug sensitive Dedihydromitomycin B 27590 Drug sensitive Chlorambucil 2708 Drug sensitive Deoxycamptothecin 266552 Drug sensitive 1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea 26328 Drug sensitive 2'-Deoxy-5-(trifluoromethyl)uridine 253083 Drug sensitive 9H-Purine, 6-(benzylthio)-9-(2-chloroethyl)- 246230 Drug sensitive Camptothecin 24360 Drug sensitive Mepacrine mustard dihydrochloride 24180972 Drug sensitive 9H-Purine, 2-amino-6-(o-chlorobenzylthio)-9-propyl- 239486 Drug sensitive Amsacrine 2179 Drug sensitive Pirarubicin hydrochloride 20846247 Drug sensitive Azaribine 16574 Drug sensitive GemMP[10] 16129935 Drug sensitive 1,2:5,6-Dianhydrogalactitol 15942827 Drug sensitive Sulfanilanilide, 4'-(9-acridinylamino)- 148802 Drug sensitive Ellipticine analog 148569 Drug sensitive Methyl (3'R)-3,4',9',10-tetrahydroxy-3'-[(2S,4R,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-7'-methoxy-5',8',9-trioxospiro[3,4-dihydropyrano[4,3-g]chromene-2,2'-3H-benzo[f][1]benzofuran]-7-carboxylate 137326876 Drug sensitive 2,4-Dihydroxybenzaldehyde 2-pyridylhydrazone 135509512 Drug sensitive Oxanthrazole 135502299 Drug sensitive 1-Phenazinecarboxylic acid, 6-formyl-4,7,9-trihydroxy-, methyl ester 135457300 Drug sensitive 2-Methylpropyl (3Z)-2-oxo-3-[(4-sulfamoylanilino)methylidene]-1H-indole-5-carboxylate 135421141 Drug sensitive Raltitrexed 135400182 Drug sensitive [(3S)-7-Oxo-6-[[(E,2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8-methyl-non-6-enoyl]amino]azepan-3-yl] tetradecanoate 134816767 Drug sensitive Saintopin 131350 Drug sensitive Porfiromycin 13116 Drug sensitive 1,4-Bis((2-aminoethyl)amino)-5,8-dihydroxy-9,10-anthraquinone 125982 Drug sensitive Clofarabine 119182 Drug sensitive Indotecan 11533060 Drug sensitive 2,2'-Bioxirane 11254 Drug sensitive Gentian violet 11057 Drug sensitive Clomesone 100651 Drug sensitive N,N-Bis(2-chloroethyl)-p-toluidine 100400 Drug sensitive arabinofuranosyl cytosine 5'-oleyl phosphate monosodium, - Drug resistant benzene, 1-methoxy-4-(2-nitroethenyl)-, (e)- - Drug resistant (1s,2e,4r,6r,7e,10r,11e)-2,7,11-cembratriene-4,6,10-triol - Drug sensitive 1,4-bis(n-cysteinyldiethylamino)-5,8-dihydroxy anthraquinon - Drug sensitive 1,8-naphthyridin-3-amine, 2,7-dichloro-5-methyl- - Drug sensitive 2,3-butanediol, 1,4-bis(2-methyl-1-aziridinyl)- (8ci) - Drug sensitive 3-piperidinone, 3,5-bis[(3,4-dichlorophenyl)methylene]- - Drug sensitive 4-piperidinone, 3,5-bis[(4-fluorophenyl)methylene]-, (e,e)- - Drug sensitive cholestan-5.alpha.-ol-3,6-dione - Drug sensitive tris(1,3-diphenylpropane-1,3-dionata)gallium(iii) - Drug sensitive 2-(n-d-glysoyl)aminobenzothiazole - Drug sensitive 4-bromo-2-(2-hydroxy-3-methyl-3-butenyl)phenol - Drug sensitive Aminocamptothecin - Drug sensitive analog of cc-1065 - Drug sensitive Annamycin Liposomal - Drug sensitive Anthrapyrazole derivative - Drug sensitive antineoplastic-d665839 - Drug sensitive Aphidicoline glycinate - Drug sensitive Camptothecin Derivative - Drug sensitive Chlorozotocin - Drug sensitive CI-921: amsacrine derivative - Drug sensitive Cyanomorpholinodoxorubicin - Drug sensitive devadarool (erthoxydiol-x) - Drug sensitive ether-20 - Drug sensitive Indenoisoquinoline derivative - Drug sensitive insulin-methotrexate conjugate - Drug sensitive largomycin f-ii - Drug sensitive merophan - Drug sensitive michicarcin - Drug sensitive mitaplatin - Drug sensitive protein: pa30-14 - Drug sensitive protein: pahiv4 - Drug sensitive pyrazoline derivative - Drug sensitive stereoisomer of nsc 675784-h - Drug sensitive trimethyl(phenylthio)stannane - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-212-3p	Hyaluronidase 91820602 Drug interaction    RC00002064 Cianidanol 9064 Drug interaction    RC00002055 Gemcitabine 60750 Drug interaction    RC00002059 Progesterone 5994 Drug interaction    RC00002054 Imatinib 5291 Drug interaction    RC00002053 Morphine 5288826 Drug interaction    RC00002063 Cocaine 446220 Drug interaction    RC00002062 Cocaine 446220 Drug interaction    RC00004777 Paroxetine 43815 Drug interaction    RC00002058 Enoxacin 3229 Drug interaction    RC00002052 Doxorubicin 31703 Drug interaction    RC00002057 Arsenic trioxide 14888 Drug interaction    RC00002056 Docetaxel 148124 Drug interaction    RC00002061 Imatinib mesylate 123596 Drug interaction    RC00002060 Heparin - Drug interaction    RC00002065 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00002066 Interleukin 13 (IL-13) - Drug interaction    RC00002067

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-212-3p
Interactor2: MYL9

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	microRNA.org//PITA//Targetscan
Support Database	ViRBase

References:

PMID	29059211	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HUVECs	Interactor2 expression	None
Description	The differential miRNAs and their target genes in the above pathways were concluded in Table S1 and Table S2.