Detail Information

Basic Information:


  VIRBase ID:  

HHID00082093

  Virus:  

Suid betaherpesvirus 2

  Host:  

Sus scrofa

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol ssc-miR-18a CDK6
miRBase
Accession/Entrez ID		 MIMAT0002161 100518921
Organism Sus scrofa Sus scrofa
Category miRNA lncRNA
Alias - -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ssc-miR-18a
Exosome Porcine milk     24499489

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug CDK6
Eunicin-cyclobilactone       9976935
6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide       9956222
6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile       9956119
Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-       9952773
5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride       9938202
1,2-Ethanediamine, N-(1,8-dimethylimidazo(1,2-a)quinoxalin-4-yl)-, monohydrochloride       9926054
Tivozanib       9911830
Zibotentan       9910224
5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide       9903786
PI-103       9884685
2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide       9874913
Osi-930       9868037
5Z-7-Oxozeaenol       9863776
2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine       9858940
Midostaurin       9829523
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528
Mannich bases       9567537
8-Hydroxy-7-(6-sulfo-naphthalen-2-ylazo)-quinoline-5-sulfonic acid       92577
(E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one       78243717
2-Methoxy-N-(3-Methyl-2-Oxo-1,2,3,4-Tetrahydroquinazolin-6-Yl)benzenesulfonamide       71271629
N-(3-Methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine       704473
(S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide       6918848
Panobinostat       6918837
Belinostat       6918638
2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide       6918454
Fumagillin       6917655
Daporinad       6914657
Imexon       68791
N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide       6852167
Strychnopentamine       6712640
Andrastin A       6712564
(4R,6Ar,12aR,14bR)-3-acetyloxy-4,6a,6b,8a,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicene-4-carboxylic acid       6711382
Pyrazolo[1,5-b]pyridazine deriv. 40       6539382
AICA ribonucleotide       65110
Tanespimycin       6505803
Ispinesib mesylate       6450816
Axitinib       6450551
Pelitinib       6445562
Dacinostat       6445533
Nilotinib       644241
Faeriefungin B       6441204
Piperlongumine       637858
Cytarabine       6253
Gemcitabine       60750
Mitomycin       5746
(2-(Phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone)       57339144
1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea       56962337
Dimethyloxalylglycine       560326
l-685,458       5479543
3-{(2-Carboxy-ethyl)-[4-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenyl]-amino}-propionic acid       5469598
2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid       54685215
Lfm-a13       54676905
Isostrychnopentamine A trihydrochloride       54611556
Crassin cinnamate       5458572
Temozolomide       5394
Ajoene       5386591
Bleomycin a2       5360373
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide       53340664
Palbociclib       5330286
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[(E)-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)ethenyl]-4-methylbenzamide       53302361
Landomycin E       53297398
Bosutinib       5328940
Methyl 5-[2-(4-hydroxy-2,6-dimethylphenyl)ethenyl]pyridine-3-carboxylate       53239945
Vorinostat       5311
5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dione       5289247
Rutacridone epoxide       5281850
2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one       5278396
Bis(2-hydroxy-1-naphthyl) disulfide       521106
2-{[4-(5-Ethylpyrimidin-4-Yl)piperazin-1-Yl]methyl}-5-(Trifluoromethyl)-1h-Benzimidazole       51371303
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide       5113032
Tubastatin A       49850262
5-Tert-butyl-1H-pyrazole; trichlororuthenium       498460
Alectinib       49806720
(25S)-25,27-Dihydrophysalin A       495589
Shikonin       479503
Phenylmethylsulfonyl fluoride       4784
2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]-N-Ethylacetamide       46943432
(S)-(+)-Tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate       46907787
3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea       46885626
Avagacestat       46883536
2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine       46224516
N-(6,6-Dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide       46191454
5-Epi-phomopsolide D       45028011
N-(2,2,2-Trifluoroethyl)-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzenesulfonamide       447912
1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine       44551660
Tretinoin       444795
Dabrafenib       44462760
Refametinib       44182295
2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid       44137675
Benzofurazan, 7-(4-benzyl-1-piperazinyl)-4-nitro-, 1-oxide       43795
Foretinib       42642645
Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide       42640
(2S)-2-[[2-(2,3-Dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]-6-purinyl]amino]-3-phenyl-1-propanol       42623900
2-(4-Amino-3-(trimethylsilylaceylenyl)phenyl)benzothiazole       404147
Artocarpesin       399491
Cirensenoxide G       399208
9-(5-Nitropyridin-2-yl)-3H-purine-2,6-dione       389377
3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one       387973
3,6-Bis(methylsulfanyl)-1,2-dihydro-1,2,4,5-tetrazine       384502
Stereoisomer of NSC 674066-O       384359
3,3-Diiodo-2-phenyl-2-propenal       381579
2,6-Dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol       3796
2-Bromo-8-hydroxy-6-methylnaphthoquinone       378439
3,8-Dimethyl-1,2-naphthoquinone       373912
9-[(4-Nitrophenyl)methylsulfanyl]acridin-3-amine       371147
1-(3-Ethynylphenyl)-2,5-pyrrolidinedione       366009
Etoposide       36462
Methyl 2-formylbicyclo[2.2.1]hepta-2,5-diene-3-carboxylate       361733
1,7-Diiminopyrrolo[3,4-f]isoindole-3,5-diamine       359178
3-Chloropropyl disulfide       355642
2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide       3463933
5-Fluorouracil       3385
Benzyl-4-(benzyloxy)-5,6-dimethylpicolinate       325113
Doxorubicin       31703
Thymolphthalein       31316
Methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-phenylbenzoyl]amino]-4-methylsulfanylbutanoate       3005532
Tamoxifen       2733526
7-Methyljuglone       26905
Carmustine       2578
[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol       25262965
2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide       25257557
3-Amino-N-(4-butoxyphenyl)-1H-indazole-1-carboxamide       25199443
Brucine, dihydro-       251913
Omipalisib       25167777
Ruxolitinib       25126798
Cabozantinib       25102847
2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid       25022668
Navitoclax       24978538
Tert-Butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate       24951314
Quizartinib       24889392
Ponatinib       24826799
Vismodegib       24776445
4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide       24772860
Cudc-101       24756910
N-(2-Iodylphenyl)-N-methylpivalamide       24205923
[3-(4-Chloro-phenyl)-3-oxo-propenylamino]-acetonitrile       24203420
Vincaleukoblastine       241903
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide       24180719
Bicalutamide       2375
Olaparib       23725625
(2E,5E)-2,5-Bis(thiophen-2-ylmethylene)cyclopentanone       2314623
4,5,6-Trichloro-2-methylpyrimidine       231054
Propiophenone, 3-phenyl-3-piperidino-       219163
Lenalidomide       216326
Sorafenib       216239
Enzastaurin       176167
4-Chloro-5-phenoxy-3H-1,2-dithiole-3-thione       16766044
4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide       16747388
Gsk-690693       16725726
Fedratinib       16722836
Obatoclax mesylate       16681698
Diallyl disulfide       16590
Dihydroguaiaretic acid       161924
N-(3-{[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-[2-(morpholin-4-yl)ethoxy]benzamide       16095342
2,4,5,6-Tetrachloropyrimidine       15690
Irofulven       148189
1-(Tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea       1401
2'-Deoxyuridine       13712
(Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide       135659062
C8, Carbonyl prodigiosine       135540857
Luminespib       135539077
4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone       135440466
Cytallene       135436546
(E)-5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime       135421339
Pac-1       135421197
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one       135418940
6-Chloro-7-(2-chloroethoxy)-5,8-dihydroxynaphthalene-1,4-dione       135409156
2-Chloro-3-(3-chloro-propyloxy)-naphthazarin       135409155
2-Chloro-3-[2-(2-butoxyethoxy)ethoxy]-naphthazarin       135409154
8-Azaguanine       135403646
DTIC-Dome       135398738
Osi-027       135398516
Dovitinib       135398510
Akt inhibitor VIII       135398501
Methotrexate       126941
Lestaurtinib       126565
Gefitinib       123631
Dactolisib       11977753
Veliparib       11960529
Uprolide H       11824652
BAY 61-3606 dihydrochloride       11784504
N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-YL)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide       11754511
PF-00562271 free base       11713159
Trametinib       11707110
4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine       11647372
4-[2-(2-Chloro-4-fluoroanilino)-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide       11634725
Crizotinib       11626560
Idelalisib       11625818
JNK Inhibitor VIII       11624601
5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine       11617559
Serdemetan       11609586
Benzamide, 4-((1R)-1-aminoethyl)-N-1H-pyrrolo(2,3-b)pyridin-4-yl-, hydrochloride (1:1)       11507964
5-(2-Phenylpyrazolo[1,5-A]pyridin-3-YL)-1H-pyrazolo[3,4-C]pyridazin-3-amine       11493598
Linifanib       11485656
N-(6-Fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide       11373846
4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide       11338033
8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one       11327430
Amuvatinib       11282283
(S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide       11152667
7-Ethyl-10-hydroxycamptothecin       104842
5,7-Dihydroxy-2-(4-Hydroxyphenyl)-4-Oxo-4h-Chromen-3-Yl 3,4-Di-O-Acetyl-6-Deoxy-alpha-L-Mannopyranoside       10459196
VX-702       10341154
Afatinib       10184653
(-)-Cinchonidine       101744
4-Demethylcalycopterone       101664523
Selumetinib       10127622
N-(3-{[5-Iodo-4-({3-[(Thiophen-2-Ylcarbonyl)amino]propyl}amino)pyrimidin-2-Yl]amino}phenyl)pyrrolidine-1-Carboxamide       10077147
Pyrazine, 2,2'-(o-chlorobenzylidenediimino)di-       100764
Masitinib       10074640
Longikaurin B       10046926
PDK1 inhibitor AR-12       10027278
1,1'-(benzo[d][1,3]dioxol-5-ylmethylene)dipiperazine       -
1,1'-biphenyl, 4,4'bis(thiomethyl)-       -
1,1-dimethylethyl methyl diester, (z, e)       -
1,2-cyclohexanediamine, platinum complex (9ci)       -
1,3-dithiolo[3,4-d]pyrimidine-2-thione, 5,7-dichloro-       -
;1-(6-chloro-1H-benzo[d]imidazol-2-yl)-3-(4-methoxypheny...       -
1-cyclobuten-3-one, 4,4-dichloro-1-pentyl-       -
1h-imidazole-4,5-dicarboxylic acid, 2-phenyl- (9ci)       -
1-penten-4-yn-3-one, 5-(2,4-dimethoxypyrimidin-5-yl)-       -
;2-(3-chloro-4-fluorophenyl)-5-(3-(3,4,5-trimethoxypheny...       -
3-chloro-7-nitro-1,2,4-benzotriazine 1-oxide       -
7h-5,6-dithioleno[4,3-d]uracil       -
(8-8a),(8'-8'a)-tetradehydroisocalycanthine 3'a(r),3'a(r)       -
acetophenone, 4'-[[2,5-dihydroxyphenyl)methyl]amino]-       -
bis-.mu.-propionatodiaquatetrabromorhenium(ii)       -
Bleomycin (50 uM)       -
c4, carbonyl, ethyl prodigiosine       -
Cetuximab       -
;(E)-3-(3-((1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)met...       -
;(E)-3-(4-ethynylphenyl)-2-(2-(naphthalen-2-yl)vinyl)pyr...       -
;(E)-5-chloro-3-((6-(4-chlorophenyl)-2-cyclopropylimidaz...       -
Genentech Cpd 10       -
hemolysin bl proteins       -
JQ12       -
JW-7-24-1       -
KIN001-236       -
KIN001-244       -
KIN001-260       -
KIN001-266       -
KIN001-270       -
MPS-1-IN-1       -
NPK76-II-72-1       -
Nutlin-3a (-)       -
oxazolidine, 3-[(cyclohexyloxy)methyl]-4,4-dimethyl-       -
QL-X-138       -
QL-XI-92       -
QL-XII-47       -
rTRAIL       -
SB52334       -
THZ-2-102-1       -
THZ-2-49       -
TL-1-85       -
TL-2-105       -
toxin .delta.53l       -
tp4ek       -
VNLG/124       -
WZ3105       -
XMD13-2       -
XMD14-99       -
XMD15-27       -

Interaction Network (The top 100 interactions):


Interactor1: ssc-miR-18a
Interactor2: CDK6

Evidence Support:


Weak-Evidence MiRNA sequencing
Prediction-Evidence miRanda//Targetscan
Support Database ViRBase

References:


PMID 26943793 Target region 3'UTR
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line porcine macrophages Interactor2 expression None
Description The database microT-CDS (http://diana.imis.athena-innovation.gr/DianaTools/index.php r=microT_CDS/index), the positional relationships between miRNAs, and genomic annotation sets were used for the prediction of targets of the 130 DE miRNAs.To explore the regulatory roles of the DE miRNAs from this study, web prediction programs were used to predict their putative target genes (S3 Table).

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