Detail Information

Basic Information:


  VIRBase ID:  

HHID00082092

  Virus:  

Suid betaherpesvirus 2

  Host:  

Sus scrofa

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol ssc-miR-18a USP42
miRBase
Accession/Entrez ID		 MIMAT0002161 100515534
Organism Sus scrofa Sus scrofa
Category miRNA lncRNA
Alias - -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ssc-miR-18a
Exosome Porcine milk     24499489

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug USP42
Eunicin-cyclobilactone       9976935
6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide       9956222
Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-       9952773
5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride       9938202
Rucaparib       9931954
1,2-Ethanediamine, N-(1,8-dimethylimidazo(1,2-a)quinoxalin-4-yl)-, monohydrochloride       9926054
Tetrangulol       99188
Tivozanib       9911830
Zibotentan       9910224
5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide       9903786
PI-103       9884685
2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide       9874913
2-(((5-(4-(4-(3-Fluorobenzyloxy)-3-chlorophenylamino)quinazolin-6-yl)furan-2-yl)methyl)(2-(methylsulfonyl)ethyl)amino)acetonitrile       9873849
Osi-930       9868037
2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine       9858940
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528
9H-Purine, 6-(ethylthio)-9-beta-D-ribofuranosyl-(8CI)(9CI)       95846
6-Benzylthioinosine       95263
6-Hydrazinopurine       94902
8-Hydroxy-7-(6-sulfo-naphthalen-2-ylazo)-quinoline-5-sulfonic acid       92577
Pentamidine isethionate       8813
Acridine Yellow G       8672
Benzethonium chloride       8478
Phenformin       8249
5,7-Dichloroisatin       80771
3-Hydroxy-4-(phenylazo)-2-naphthoic acid       80753
(E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one       78243717
Cyclopentenyl cytosine       72828
5-Methyl-1,10-phenanthroline       72791
Berberine iodide       72350
2-Methoxy-N-(3-Methyl-2-Oxo-1,2,3,4-Tetrahydroquinazolin-6-Yl)benzenesulfonamide       71271629
N-(3-Methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine       704473
(S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide       6918848
Panobinostat       6918837
Belinostat       6918638
Ambruticin       6918547
Daporinad       6914657
N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide       6852167
1-(2-Pyridylazo)-2-naphthol       6825
Brigatinib       68165256
1H-Naphth[2,3-f]isoindole-1,3,5,10(2H)-tetrone, 4,11-diamino-       67192
17-Hydroxyjolkinolide A       6712606
Hypopistephanine       6711179
4-[2-(4-Chlorophenyl)pyrazolo[1,5-b]pyridazin-3-yl]-N-phenylpyrimidin-2-amine       6539424
AICA ribonucleotide       65110
Tanespimycin       6505803
Ispinesib mesylate       6450816
Axitinib       6450551
Pelitinib       6445562
Dacinostat       6445533
4-(N-Hydroxyacetamido)stilbene       6433723
Irinotecan       60838
Gemcitabine       60750
Topotecan       60700
Mitomycin       5746
3-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol;hydrochloride       57399804
5-[2-[4-(Aminomethyl)phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl]-2-chlorophenol;hydrochloride       57399803
(2-(Phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone)       57339144
1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea       56962337
Dimethyloxalylglycine       560326
l-685,458       5479543
8-Hydroxy-3-phenylisocoumarin       5473194
Presqualene alcohol       5471965
3-{(2-Carboxy-ethyl)-[4-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenyl]-amino}-propionic acid       5469598
2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid       54685215
Lfm-a13       54676905
Olivomycin Transformation       54610760
Curromycin A.B mixture       54608021
Eriolanin       5458307
Temozolomide       5394
Fcrc57-G       5358914
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide       53340664
Palbociclib       5330286
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[(E)-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)ethenyl]-4-methylbenzamide       53302361
Bosutinib       5328940
Vorinostat       5311
Chlorprothixene hydrochloride       5282478
2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one       5278396
Purapuridine       5250
Bis(2-hydroxy-1-naphthyl) disulfide       521106
2-{[4-(5-Ethylpyrimidin-4-Yl)piperazin-1-Yl]methyl}-5-(Trifluoromethyl)-1h-Benzimidazole       51371303
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide       5113032
Alsterpaullone       5005498
Tubastatin A       49850262
Alectinib       49806720
Cardiovite       4951
Shikonin       479503
Phenylmethylsulfonyl fluoride       4784
Pentamidine       4735
2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one       4713
2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]-N-Ethylacetamide       46943432
3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea       46885626
Avagacestat       46883536
2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine       46224516
N-(6,6-Dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide       46191454
N-(2,2,2-Trifluoroethyl)-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzenesulfonamide       447912
1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine       44551660
Tretinoin       444795
Dabrafenib       44462760
Refametinib       44182295
Ouabain       439501
Foretinib       42642645
Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide       42640
(2S)-2-[[2-(2,3-Dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]-6-purinyl]amino]-3-phenyl-1-propanol       42623900
Vemurafenib       42611257
4-Amino-1-benzylpiperidine       415852
1,6-Bis[4-(4-aminophenoxy)phenyl]diamantane       397904
5-(2-Methylanilino)-1,3-bis(2-phenoxyethyl)pyrimidine-2,4-dione       395056
9-(5-Nitropyridin-2-yl)-3H-purine-2,6-dione       389377
2,6-Dibromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol       3796
Chlorotetrangulol       379538
2-Chloro-3-amino-5,4-naphthoquinone       377211
Diisopropoxybis(1,4-naphthochinone-2-olato)titanium(IV)       368058
Etoposide       36462
1,2,4,5-Tetrazine, 3,6-bis(1-azetidinyl)-       362170
3,4-Dihydroxynaphthalene-2-carboxylic acid       356138
2,3-Dimethylbenzo[g]quinoxaline-5,10-dione       353644
Phenazine, 2-chloro-, 5,10-dioxide       343972
5-Fluorouracil       3385
Colchicine, 17-chloro-       33463
N6-Benzyladenosine-5'-phosphate       318601
Tamoxifen       2733526
[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol       25262965
2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide       25257557
Omipalisib       25167777
Ruxolitinib       25126798
Cabozantinib       25102847
2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid       25022668
Navitoclax       24978538
Tert-Butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate       24951314
Quizartinib       24889392
Ponatinib       24826799
Vismodegib       24776445
4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide       24772860
Cudc-101       24756910
2-Benzoyloxymethyl-1,4-naphthoquinone       24206039
1,2-Benzo-8-(L-alanyl)-3-phenoxazone nitrate salt       24202491
Vincaleukoblastine       241903
Antineoplastic-31815       24183928
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide       24180719
2-Chloro-3-[(furan-2-ylmethyl)amino]naphthalene-1,4-dione       239677
Bicalutamide       2375
Olaparib       23725625
(2E,5E)-2,5-Bis(thiophen-2-ylmethylene)cyclopentanone       2314623
6-Chloro-2-methoxy-9-[(5-piperidinopentyl)amino]acridine       219600
Lenalidomide       216326
Sorafenib       216239
8-Amino-5-methyl-6-phenylphenanthridin-5-ium bromide       21144180
Kinetin riboside       20345
8-Hydroxyquinoline       1923
8-Chloro-cyclicamp       17856967
Enzastaurin       176167
Adiantifoline       167937
4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide       16747388
Gsk-690693       16725726
Fedratinib       16722836
Obatoclax mesylate       16681698
Docetaxel       148124
Homidium bromide       14710
Basic violet 2       14454445
1-(Tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea       1401
N-[5-[5-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-pyridin-4-ylfuran-3-yl]-2,3-dihydroinden-1-ylidene]hydroxylamine;hydrochloride       136207967
4-[(5z)-5-(1-Nitroso-2,3-Dihydro-5h-Inden-5-Ylidene)-2-(Piperidin-4-Yl)-3,5-Dihydro-4h-Imidazol-4-Ylidene]-1,4-Dihydropyridine       136026031
(Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide       135659062
Talazoparib       135565082
N,N-Dimethyl-2-[4-[4-(1-nitroso-2,3-dihydroinden-5-ylidene)-5-(1H-pyridin-4-ylidene)-1H-imidazol-2-yl]phenoxy]ethanamine       135564599
Luminespib       135539077
Eriochrome Blue Black B       135465071
Acid orange 7       135442941
Pac-1       135421197
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one       135418940
Osi-027       135398516
Akt inhibitor VIII       135398501
Ortho-topolin riboside       13506406
Methotrexate       126941
Lestaurtinib       126565
Berberine chloride       12456
Gefitinib       123631
Veliparib       11960529
BAY 61-3606 dihydrochloride       11784504
N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-YL)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide       11754511
PF-00562271 free base       11713159
Trametinib       11707110
1-Methyl-5-[[2-[5-(trifluoromethyl)-1h-imidazol-2-yl]-4-pyridinyl]oxy]-n-[4-(trifluoromethyl)phenyl]-1h-benzimidazol-2-amine       11656518
4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine       11647372
4-[2-(2-Chloro-4-fluoroanilino)-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide       11634725
Crizotinib       11626560
Idelalisib       11625818
5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine       11617559
Benzamide, 4-((1R)-1-aminoethyl)-N-1H-pyrrolo(2,3-b)pyridin-4-yl-, hydrochloride (1:1)       11507964
5-(2-Phenylpyrazolo[1,5-A]pyridin-3-YL)-1H-pyrazolo[3,4-C]pyridazin-3-amine       11493598
Linifanib       11485656
Bafetinib       11387605
N-(6-Fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide       11373846
4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide       11338033
8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one       11327430
Pararosaniline hydrochloride       11292
Amuvatinib       11282283
Sepantronium bromide       11178236
1-Phenyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazole       11162021
(S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide       11152667
[(4-Methylphenyl)methyl](triphenyl)arsanium bromide       10672721
Dequalinium chloride       10649
7-Ethyl-10-hydroxycamptothecin       104842
5,7-Dihydroxy-2-(4-Hydroxyphenyl)-4-Oxo-4h-Chromen-3-Yl 3,4-Di-O-Acetyl-6-Deoxy-alpha-L-Mannopyranoside       10459196
VX-702       10341154
Afatinib       10184653
(-)-Cinchonidine       101744
Selumetinib       10127622
N-(3-{[5-Iodo-4-({3-[(Thiophen-2-Ylcarbonyl)amino]propyl}amino)pyrimidin-2-Yl]amino}phenyl)pyrrolidine-1-Carboxamide       10077147
Masitinib       10074640
Tocladesine       100299
PDK1 inhibitor AR-12       10027278
1,2-benzo-8-(d,l-alanyl)-3-phenoxazone nitrate salt       -
;2-(3-((2-methoxybenzyl)amino)propyl)-7-(3-((4-((3-(meth...       -
2-propen-1-one, 3-(1-naphthalenyl)-1-phenyl- (9ci)       -
2-propenone, 1,1'-(2,5-pyridinediyl)bis[3-(2-furanyl)-       -
3,3?-thiene-2,5-diylbis(5-methoxy-1h-indole)       -
3-pyridinecarboxamide, 6-(hydroxyazo)-, sodium salt       -
4,4'-dimethoxy-2,5-dienone       -
;4-fluoro-N-(3-(4-(6-(4-hydroxyphenyl)imidazo[2,1-b]thia...       -
;5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-(3,4,5-trimet...       -
5,6-ethylenediquino[3,2-b       -
aceanthryleno[1,2-b]quinoxaline, 12-nitro-       -
.alpha.-sarcin       -
antibiotic 2-79-a(5)       -
Basic Fuchsin       -
benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 3-methyl-       -
benzo[b]naphtho[2,3-d]furan-6,11-dione, 4-chloro-3-hydroxy       -
bis-.mu.-propionatodiaquatetrabromorhenium(ii)       -
Cetuximab       -
Denileukin Diftitox Ontak       -
;(E)-1-(4-methoxyphenyl)-3-(2-(3,4,5-trimethoxyphenylami...       -
;(E)-1-(benzo[d][1,3]dioxol-5-yl)-3-(2-methoxy-5-(1-(3,4...       -
;(E)-3-(3-((1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)met...       -
;(E)-3-(4-methoxy-3-((1-(4-methoxybenzyl)-1H-1,2,3-triaz...       -
gamitrinib-g4       -
Genentech Cpd 10       -
(-)-gossypol/ 0.3 hoac       -
gramicidin       -
g-tpp       -
Hypothemycin       -
ICL1100013       -
JW-7-24-1       -
KIN001-236       -
KIN001-244       -
KIN001-260       -
KIN001-266       -
KIN001-270       -
mepartricin (usan)       -
MPS-1-IN-1       -
naphtho[2,1-b]quinolizinium, 5-chloro-7-methyl- perchlorate       -
naphtho[2,3-b]furan-4,9-dione, 2-bromo-       -
naphtho[2,3-d]thiazole-4,9-dione, 3-methyl-2-(methylimino)-       -
N-methyl-N-(4-(3-(pyrrolidin-1-yl)propoxy)benzyl)-4-(2,6...       -
NPK76-II-72-1       -
nsc 701656 incorporated in micelles, 0.73% (w/w) of drug.       -
Nutlin-3a (-)       -
protein toxin a 23 - mw approx. 6700       -
protein toxin b 15 - mw approx 6700       -
protein toxin c 10 - mw approx. 6700       -
protein toxin d 5 - mw approx 6700       -
ptmc       -
QL-X-138       -
QL-XI-92       -
QL-XII-47       -
rhodium dimer       -
riboprine(usan)       -
(r)-methyl 2-cinnamamido-3-(1h-indol-3-yl)propanoate       -
rTRAIL       -
SB52334       -
thiazolo[3,2-f]phenanthridinium, 3-phenyl- perchlorate       -
THZ-2-102-1       -
THZ-2-49       -
TL-1-85       -
TL-2-105       -
Tyrothricin       -
VNLG/124       -
WZ3105       -
XMD13-2       -
XMD14-99       -
XMD15-27       -
;(Z)-1-(1H-indol-3-yl)-3-(2-methoxy-5-(3,4,5-trimethoxys...       -
;(Z)-3-chloro-N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl...       -
;(Z)-6-Methoxy-2-(5-nitrothiophene-2-ylmethylene)-3(2H)-...       -
;(Z)-N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)-...       -
;(Z)-N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)ph...       -

Interaction Network (The top 100 interactions):


Interactor1: ssc-miR-18a
Interactor2: USP42

Evidence Support:


Weak-Evidence MiRNA sequencing
Prediction-Evidence miRanda//Targetscan
Support Database ViRBase

References:


PMID 26943793 Target region 3'UTR
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line porcine macrophages Interactor2 expression None
Description The database microT-CDS (http://diana.imis.athena-innovation.gr/DianaTools/index.php r=microT_CDS/index), the positional relationships between miRNAs, and genomic annotation sets were used for the prediction of targets of the 130 DE miRNAs.To explore the regulatory roles of the DE miRNAs from this study, web prediction programs were used to predict their putative target genes (S3 Table).

Starting a new search, please wait ...