Basic Information:

  VIRBase ID:  

HHID00076466

  Virus:  

Murid betaherpesvirus 1

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-199a-3p:  MIMAT0000230          Pon2:  NM_183308     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-199a-3p	Pon2
miRBase Accession/Entrez ID	MIMAT0000230	330260
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	6330405I24Rik//AI481612

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Pon2	chr6:5264816-5264817(-) m6A 3'UTR       25683224//22608085 chr6:5264893-5264894(-) m6A 3'UTR       25683224//22608085 chr6:5264943-5264944(-) m6A 3'UTR       25683224//22608085 chr6:5265326-5265327(-) m6A CDS       25683224//24981863//25569111 chr6:5265368-5265369(-) m6A CDS       25683224//24981863 chr6:5265462-5265463(-) m6A CDS       25683224//22608085 chr6:5266130-5266131(-) m6A CDS       25683224//22608085 chr6:5266156-5266157(-) m6A CDS       25683224//22608085 chr6:5266214-5266215(-) m6A CDS       25683224//22608085 chr6:5266994-5266995(-) m6A CDS       25683224//22608085 chr6:5269079-5269080(-) m6A CDS       25683224//22608085 chr6:5269089-5269090(-) m6A CDS       25683224//22608085 chr6:5271930-5271931(-) m6A exon//intron       24981863 chr6:5271939-5271940(-) m6A exon//intron       24981863 chr6:5271944-5271945(-) m6A exon//intron       24981863 chr6:5271967-5271968(-) m6A exon//intron       24981863 chr6:5271981-5271982(-) m6A exon//intron       24981863 chr6:5272423-5272424(-) m6A CDS//exon       25683224//22608085 chr6:5273085-5273086(-) m6A CDS//exon       25683224//22608085 chr6:5277536-5277537(-) m6A exon//intron       25683224//22608085 chr6:5277911-5277912(-) m6A CDS//exon       25683224//22608085 chr6:5277924-5277925(-) m6A CDS//exon       25683224//22608085 chr6:5277976-5277977(-) m6A exon//intron       25683224//22608085 chr6:5289035-5289036(-) m6A CDS//exon       25683224//25412662//24981863//25569111 chr6:5289044-5289045(-) m6A CDS//exon       25683224//25412662//24981863//25569111

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-199a-3p	Exosome Conditioned medium of E13 SMG     28041903 Exosome B6 BMDCs     22031862

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-199a-3p
Interactor2: Pon2

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	20643939	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	NIH3T3 cells	Interactor2 expression	Downregulation
Description	All of the regulated genes in Fig. 5B are down-regulated by miR-199a-3p mimic and up-regulated by miR-199a-3p inhibitor compared with the negative transfection control, with the exception of ITGA6, which is only up-regulated by the inhibitor (Dataset S3).