Basic Information:

  VIRBase ID:  

HHID00076453

  Virus:  

Murid betaherpesvirus 1

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-199a-3p:  MIMAT0000230          Tubb4b:  NM_146116     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-199a-3p	Tubb4b
miRBase Accession/Entrez ID	MIMAT0000230	227613
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	4930542G03Rik//Tubb2c//Tubb2c1

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Tubb4b	chr2:25222270-25222271(-) m6A 3'UTR       25683224//25412662//24981863//25456834//25569111 chr2:25222594-25222595(-) m6A CDS       25683224//25412662//24981863//25569111//22575960 chr2:25222635-25222636(-) m6A CDS       25683224//25412662//24981863//25569111 chr2:25222641-25222642(-) m6A CDS       25683224//25412662//24981863//25569111 chr2:25222661-25222662(-) m6A CDS       25683224//25412662//24981863//25569111 chr2:25222727-25222728(-) m6A CDS       25683224//24981863//25569111 chr2:25222752-25222753(-) m6A CDS       25683224//24981863//25569111 chr2:25222889-25222890(-) m6A CDS       25683224//24981863//25569111 chr2:25222968-25222969(-) m6A CDS       24981863//25569111 chr2:25223005-25223006(-) m6A CDS       24981863//25569111 chr2:25223050-25223051(-) m6A CDS       24981863//25569111//22608085 chr2:25223061-25223062(-) m6A CDS       25683224//24981863//25569111//22608085 chr2:25223115-25223116(-) m6A CDS       25683224//25412662//24981863//25569111//22608085 chr2:25223151-25223152(-) m6A CDS       25683224//25412662//24981863//25569111//22608085 chr2:25223163-25223164(-) m6A CDS       25683224//25412662//24981863//25569111//22608085 chr2:25223218-25223219(-) m6A CDS       25683224//25412662//24981863//25569111 chr2:25223349-25223350(-) m6A CDS       25683224//25412662//24981863//25569111//22608085 chr2:25223544-25223545(-) m6A exon//intron       25683224//25412662//24981863//25569111//22608085 chr2:25223551-25223552(-) m6A exon//intron       25683224//25412662//24981863//25569111//22608085 chr2:25223567-25223568(-) m6A exon//intron       25683224//24981863//25569111//22608085 chr2:25223952-25223953(-) m6A CDS//exon       25683224//24981863//25569111//22608085 chr2:25223989-25223990(-) m6A CDS//exon       25683224//24981863//25569111//22608085 chr2:25224010-25224011(-) m6A CDS//exon       25683224//24981863//25569111//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-199a-3p	Exosome Conditioned medium of E13 SMG     28041903 Exosome B6 BMDCs     22031862

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-199a-3p
Interactor2: Tubb4b

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	20643939	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	NIH3T3 cells	Interactor2 expression	Downregulation
Description	All of the regulated genes in Fig. 5B are down-regulated by miR-199a-3p mimic and up-regulated by miR-199a-3p inhibitor compared with the negative transfection control, with the exception of ITGA6, which is only up-regulated by the inhibitor (Dataset S3).