Basic Information:

  VIRBase ID:  

HHID00076438

  Virus:  

Murid betaherpesvirus 1

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-199a-3p:  MIMAT0000230          Hspa1a:  NM_010479     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-199a-3p	Hspa1a
miRBase Accession/Entrez ID	MIMAT0000230	193740
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	Hsp//hsp68//Hsp7//Hsp70//Hsp70-3//Hsp70.3//hsp70A1//Hsp72

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Hspa1a	chr17:34969376-34969377(-) m6A 3'UTR       24981863 chr17:34969411-34969412(-) m6A 3'UTR       24981863 chr17:34969468-34969469(-) m6A 3'UTR       24981863//25569111//22608085 chr17:34969488-34969489(-) m6A 3'UTR       24981863//25569111//22608085 chr17:34969541-34969542(-) m6A 3'UTR       25683224//24981863//25569111//22608085 chr17:34969620-34969621(-) m6A 3'UTR       25683224//24981863//25456834//25569111//22608085 chr17:34969643-34969644(-) m6A 3'UTR       25683224//24981863//25569111//22608085 chr17:34969653-34969654(-) m6A 3'UTR       25683224//24981863//25569111//22608085 chr17:34969672-34969673(-) m6A 3'UTR       25683224//24981863//25569111//22608085 chr17:34969721-34969722(-) m6A 3'UTR       25683224//24981863//25569111//22608085 chr17:34969868-34969869(-) m6A 3'UTR       24981863//25569111//22608085 chr17:34969873-34969874(-) m6A 3'UTR       24981863//25569111//22608085 chr17:34969883-34969884(-) m6A 3'UTR       24981863//25569111//22608085 chr17:34969943-34969944(-) m6A 3'UTR       24981863//25569111//22608085 chr17:34969963-34969964(-) m6A 3'UTR       24981863//25569111//22608085 chr17:34970023-34970024(-) m6A CDS       24981863//25569111 chr17:34970180-34970181(-) m6A CDS       25683224//25412662//24981863 chr17:34970210-34970211(-) m6A CDS       25683224//25412662//24981863//25569111 chr17:34970545-34970546(-) m6A CDS       25683224//24981863//25569111 chr17:34970627-34970628(-) m6A CDS       25683224//24981863 chr17:34970646-34970647(-) m6A CDS       25683224//24981863 chr17:34970712-34970713(-) m6A CDS       24981863 chr17:34970756-34970757(-) m6A CDS       24981863 chr17:34970777-34970778(-) m6A CDS       24981863 chr17:34970846-34970847(-) m6A CDS       24981863 chr17:34970870-34970871(-) m6A CDS       25683224//24981863 chr17:34970945-34970946(-) m6A CDS       25683224//24981863//25569111 chr17:34971002-34971003(-) m6A CDS       25683224//24981863//25569111 chr17:34971158-34971159(-) m6A CDS       25683224//24981863 chr17:34971170-34971171(-) m6A CDS       25683224//24981863 chr17:34971731-34971732(-) m6A CDS       25412662 chr17:34971740-34971741(-) m6A CDS       25412662//24981863 chr17:34971755-34971756(-) m6A CDS       25412662//24981863 chr17:34971914-34971915(-) m6A CDS       24981863 chr17:34972053-34972054(-) m6A 5'UTR       25683224//25412662//24981863//25569111 chr17:34972098-34972099(-) m6A 5'UTR       25683224//25412662//24981863//25569111 chr17:34972108-34972109(-) m6A 5'UTR       25683224//25412662//24981863//25569111 chr17:34972131-34972132(-) m6A 5'UTR       25683224//25412662//24981863//25569111

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-199a-3p	Exosome Conditioned medium of E13 SMG     28041903 Exosome B6 BMDCs     22031862
	Hspa1a	Cytoplasm Neuroblastoma cell line (N2A)     22406755

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-199a-3p
Interactor2: Hspa1a

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	20643939	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	NIH3T3 cells	Interactor2 expression	Downregulation
Description	All of the regulated genes in Fig. 5B are down-regulated by miR-199a-3p mimic and up-regulated by miR-199a-3p inhibitor compared with the negative transfection control, with the exception of ITGA6, which is only up-regulated by the inhibitor (Dataset S3).