Basic Information:

  VIRBase ID:  

HHID00076429

  Virus:  

Murid betaherpesvirus 1

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-199a-3p:  MIMAT0000230          Arrdc3:  NR_153410     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-199a-3p	Arrdc3
miRBase Accession/Entrez ID	MIMAT0000230	105171
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	AI450344//mKIAA1376

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Arrdc3	chr13:80883807-80883808(+) m6A CDS//exon       24981863//22608085 chr13:80887423-80887424(+) m1A 5'UTR//CDS//exon       26863196 chr13:80891521-80891522(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr13:80891584-80891585(+) m6A 3'UTR//CDS//exon       25569111 chr13:80893400-80893401(+) m6A 3'UTR//CDS       25412662//24981863//25569111//22608085 chr13:80893404-80893405(+) m6A 3'UTR//CDS       25683224//25456834//25412662//24981863//25569111//22575960 chr13:80893464-80893465(+) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr13:80893486-80893487(+) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr13:80893505-80893506(+) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr13:80893542-80893543(+) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr13:80893553-80893554(+) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr13:80893562-80893563(+) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr13:80893648-80893649(+) m6A 3'UTR       25456834//25412662//24981863//25569111//22608085//22575960 chr13:80893699-80893700(+) m6A 3'UTR       25456834//24981863//25569111//22608085//22575960 chr13:80893810-80893811(+) m6A 3'UTR       25456834//24981863//25569111//22608085//22575960 chr13:80893855-80893856(+) m6A 3'UTR       25683224//25456834//24981863//25569111//22608085//22575960 chr13:80893875-80893876(+) m6A 3'UTR       25683224//25456834//24981863//25569111//22608085//22575960 chr13:80893892-80893893(+) m6A 3'UTR       25683224//25456834//24981863//25569111//22608085//22575960 chr13:80893897-80893898(+) m6A 3'UTR       25683224//25456834//24981863//25569111//22608085//22575960 chr13:80893988-80893989(+) m6A 3'UTR       25683224//25456834//24981863//25569111//22608085//22575960 chr13:80894082-80894083(+) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr13:80894168-80894169(+) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr13:80894192-80894193(+) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr13:80894316-80894317(+) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr13:80894421-80894422(+) m6A 3'UTR       24981863//25569111 chr13:80894432-80894433(+) m6A 3'UTR       24981863//25569111 chr13:80894481-80894482(+) m6A 3'UTR       25569111 chr13:80894503-80894504(+) m6A 3'UTR       25569111 chr13:80895377-80895378(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-199a-3p	Exosome Conditioned medium of E13 SMG     28041903 Exosome B6 BMDCs     22031862

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-199a-3p
Interactor2: Arrdc3

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	20643939	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	NIH3T3 cells	Interactor2 expression	Downregulation
Description	All of the regulated genes in Fig. 5B are down-regulated by miR-199a-3p mimic and up-regulated by miR-199a-3p inhibitor compared with the negative transfection control, with the exception of ITGA6, which is only up-regulated by the inhibitor (Dataset S3).