Basic Information:

  VIRBase ID:  

HHID00076426

  Virus:  

Murid betaherpesvirus 1

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-199a-3p:  MIMAT0000230          Cnih4:  NM_030131     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-199a-3p	Cnih4
miRBase Accession/Entrez ID	MIMAT0000230	98417
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	AI647760//AW050376//CNIH-4//D530030D03Rik//E430023H19Rik//HSPC163

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Cnih4	chr1:181144873-181144874(+) m6A 5'UTR       24981863 chr1:181144878-181144879(+) m6A 5'UTR       24981863 chr1:181144883-181144884(+) m6A 5'UTR       24981863 chr1:181166269-181166270(+) m6A 3'UTR//exon       24981863 chr1:181166277-181166278(+) m6A 3'UTR//exon       24981863 chr1:181166289-181166290(+) m6A 3'UTR//exon       24981863 chr1:181166324-181166325(+) m6A 3'UTR//exon       24981863 chr1:181166337-181166338(+) m6A 3'UTR//exon       24981863 chr1:181167182-181167183(+) m6A 3'UTR       25683224//22608085 chr1:181167205-181167206(+) m6A 3'UTR       25683224//22608085 chr1:181168129-181168130(+) m6A 3'UTR       24981863 chr1:181168144-181168145(+) m6A 3'UTR       24981863 chr1:181168191-181168192(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-199a-3p	Exosome Conditioned medium of E13 SMG     28041903 Exosome B6 BMDCs     22031862

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-199a-3p
Interactor2: Cnih4

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	20643939	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	NIH3T3 cells	Interactor2 expression	Downregulation
Description	All of the regulated genes in Fig. 5B are down-regulated by miR-199a-3p mimic and up-regulated by miR-199a-3p inhibitor compared with the negative transfection control, with the exception of ITGA6, which is only up-regulated by the inhibitor (Dataset S3).