Basic Information:

  VIRBase ID:  

HHID00076425

  Virus:  

Murid betaherpesvirus 1

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-199a-3p:  MIMAT0000230          Plekha3:  NM_031256     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-199a-3p	Plekha3
miRBase Accession/Entrez ID	MIMAT0000230	83435
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	FA//FAPP1

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Plekha3	chr2:76675305-76675306(+) m6A 5'UTR       25412662//24981863//25456834//25569111 chr2:76682741-76682742(+) m6A CDS       24981863//22608085 chr2:76682814-76682815(+) m6A CDS       25412662//24981863//22608085 chr2:76682869-76682870(+) m6A CDS       25412662//24981863//22608085 chr2:76686629-76686630(+) m6A CDS       24981863//22608085 chr2:76692669-76692670(+) m6A CDS//exon       25569111//22608085 chr2:76692712-76692713(+) m6A CDS//exon       25569111//22608085 chr2:76692722-76692723(+) m6A CDS//exon       25569111//22608085 chr2:76692728-76692729(+) m6A CDS//exon       25569111//22608085 chr2:76692755-76692756(+) m6A CDS//exon       25569111//22608085 chr2:76695404-76695405(+) m6A CDS       25412662//25569111//22608085 chr2:76695453-76695454(+) m6A CDS       25412662//25569111//22608085 chr2:76695466-76695467(+) m6A CDS       25412662//22608085 chr2:76695480-76695481(+) m6A CDS       25412662//22608085 chr2:76695506-76695507(+) m6A 3'UTR       25412662//22608085 chr2:76695535-76695536(+) m6A 3'UTR       25412662//22608085 chr2:76695564-76695565(+) m6A 3'UTR       25412662//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-199a-3p	Exosome Conditioned medium of E13 SMG     28041903 Exosome B6 BMDCs     22031862
	Plekha3	Exosome Mast cells     17486113

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-199a-3p
Interactor2: Plekha3

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	20643939	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	NIH3T3 cells	Interactor2 expression	Downregulation
Description	All of the regulated genes in Fig. 5B are down-regulated by miR-199a-3p mimic and up-regulated by miR-199a-3p inhibitor compared with the negative transfection control, with the exception of ITGA6, which is only up-regulated by the inhibitor (Dataset S3).