Basic Information:

  VIRBase ID:  

HHID00076423

  Virus:  

Murid betaherpesvirus 1

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-199a-3p:  MIMAT0000230          Lbh:  NM_029999     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-199a-3p	Lbh
miRBase Accession/Entrez ID	MIMAT0000230	77889
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	1810009F10Rik//6720416L16Rik

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Lbh	chr17:72918306-72918307(+) m6A 5'UTR       25412662//24981863//25569111 chr17:72918385-72918386(+) m6A 5'UTR       25683224//25412662//24981863//25569111 chr17:72918457-72918458(+) m6A 5'UTR       25683224//25412662//24981863//25569111 chr17:72918547-72918548(+) m6A 5'UTR       25683224//25569111//22608085 chr17:72937945-72937946(+) m6A 3'UTR//intron       25683224//24981863//25569111//22608085 chr17:72937957-72937958(+) m6A 3'UTR//intron       25683224//24981863//25569111//22608085 chr17:72938010-72938011(+) m6A 3'UTR//intron       25683224//25412662//24981863//25569111 chr17:72939265-72939266(+) m6A 3'UTR//CDS       25683224//25412662//24981863//25569111 chr17:72939274-72939275(+) m6A 3'UTR//CDS       25683224//25412662//24981863//25569111 chr17:72939301-72939302(+) m6A 3'UTR//CDS       25683224//25412662//24981863//25569111 chr17:72939326-72939327(+) m6A 3'UTR//CDS       25683224//25412662//24981863//25569111 chr17:72939403-72939404(+) m6A CDS       25683224//25412662//24981863//25569111//22608085 chr17:72939417-72939418(+) m6A CDS       25683224//25412662//24981863//25569111//22608085 chr17:72939436-72939437(+) m6A CDS       25683224//25412662//24981863//25569111//22608085 chr17:72939488-72939489(+) m6A 3'UTR       25683224//25412662//24981863//25569111//22608085 chr17:72939700-72939701(+) m6A 3'UTR       25683224//25412662//24981863//25569111//22608085 chr17:72939757-72939758(+) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085 chr17:72939865-72939866(+) m6A 3'UTR       25683224//25456834//24981863//25569111//22608085 chr17:72939882-72939883(+) m6A 3'UTR       25683224//25456834//24981863//25569111//22608085 chr17:72939887-72939888(+) m6A 3'UTR       25683224//25456834//24981863//25569111//22608085 chr17:72939892-72939893(+) m6A 3'UTR       25683224//25456834//24981863//25569111//22608085 chr17:72939916-72939917(+) m6A 3'UTR       25683224//24981863//25456834//25569111//22608085 chr17:72940073-72940074(+) m6A 3'UTR       25683224//24981863//25569111 chr17:72940115-72940116(+) m6A 3'UTR       25683224//24981863//25569111 chr17:72940163-72940164(+) m6A 3'UTR       25683224//24981863//25569111 chr17:72940180-72940181(+) m6A 3'UTR       25683224//24981863//25569111 chr17:72940242-72940243(+) m6A 3'UTR       25569111 chr17:72940645-72940646(+) m6A 3'UTR       25683224//22608085 chr17:72940838-72940839(+) m6A 3'UTR       25683224//22608085 chr17:72940863-72940864(+) m6A 3'UTR       25683224//22608085 chr17:72940902-72940903(+) m6A 3'UTR       25683224//22608085 chr17:72940997-72940998(+) m6A 3'UTR       25683224//22608085 chr17:72941518-72941519(+) m6A 3'UTR       25683224//22608085 chr17:72941528-72941529(+) m6A 3'UTR       25683224//25412662//22608085 chr17:72941601-72941602(+) m6A 3'UTR       25683224//25412662 chr17:72941617-72941618(+) m6A 3'UTR       25683224//25412662

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-199a-3p	Exosome Conditioned medium of E13 SMG     28041903 Exosome B6 BMDCs     22031862
	Lbh	Cytoplasm Neuroblastoma cell line (N2A)     22406755

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-199a-3p
Interactor2: Lbh

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	20643939	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	NIH3T3 cells	Interactor2 expression	Downregulation
Description	All of the regulated genes in Fig. 5B are down-regulated by miR-199a-3p mimic and up-regulated by miR-199a-3p inhibitor compared with the negative transfection control, with the exception of ITGA6, which is only up-regulated by the inhibitor (Dataset S3).