Basic Information:

  VIRBase ID:  

HHID00076391

  Virus:  

Murid betaherpesvirus 1

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-199a-3p:  MIMAT0000230          Coq10b:  NM_026424     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-199a-3p	Coq10b
miRBase Accession/Entrez ID	MIMAT0000230	67876
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	1500041J02Rik//1700030I21Rik//9530077A17Rik//AV002237//AW742641

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Coq10b	chr1:55052892-55052893(+) m6A CDS//exon       25412662//24981863//25569111 chr1:55061303-55061304(+) m6A CDS//exon//intron       24981863 chr1:55061308-55061309(+) m6A CDS//exon//intron       24981863 chr1:55061356-55061357(+) m6A CDS//exon//intron       24981863 chr1:55071703-55071704(+) m6A CDS       24981863 chr1:55071739-55071740(+) m6A CDS       25456834//24981863 chr1:55071755-55071756(+) m6A CDS       25456834//24981863//22608085 chr1:55071901-55071902(+) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr1:55071947-55071948(+) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr1:55071953-55071954(+) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr1:55072095-55072096(+) m6A 3'UTR       25456834//24981863 chr1:55072247-55072248(+) Y 3'UTR//exon       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-199a-3p	Exosome Conditioned medium of E13 SMG     28041903 Exosome B6 BMDCs     22031862

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-199a-3p
Interactor2: Coq10b

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	20643939	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	NIH3T3 cells	Interactor2 expression	Downregulation
Description	All of the regulated genes in Fig. 5B are down-regulated by miR-199a-3p mimic and up-regulated by miR-199a-3p inhibitor compared with the negative transfection control, with the exception of ITGA6, which is only up-regulated by the inhibitor (Dataset S3).