Basic Information:

  VIRBase ID:  

HHID00076390

  Virus:  

Murid betaherpesvirus 1

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-199a-3p:  MIMAT0000230          Dusp6:  NM_026268     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-199a-3p	Dusp6
miRBase Accession/Entrez ID	MIMAT0000230	67603
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	1300019I03Rik//MKP//MKP-//MKP-3//MKP3//PYS//PYST1

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Dusp6	chr10:99263283-99263284(+) m6A 5'UTR       25683224//25456834//24981863//25569111//22608085 chr10:99263294-99263295(+) m6A 5'UTR       25683224//25456834//24981863//25569111//22608085 chr10:99263321-99263322(+) m6A 5'UTR       25683224//25456834//24981863//25569111//22608085 chr10:99263375-99263376(+) m6A 5'UTR       25683224//25456834//25412662//24981863//25569111//22608085 chr10:99263451-99263452(+) m6A 5'UTR       25683224//25456834//25412662//24981863//25569111 chr10:99263456-99263457(+) m6A 5'UTR       25683224//25456834//25412662//24981863//25569111 chr10:99263518-99263519(+) m6A 5'UTR       25683224//25456834//25412662//24981863//25569111 chr10:99263590-99263591(+) m6A 5'UTR       25683224//25412662//24981863//25569111 chr10:99263708-99263709(+) m6A CDS       25683224//25412662//24981863//25569111 chr10:99263803-99263804(+) m6A CDS       25683224//25412662//24981863//25569111//22575960 chr10:99263935-99263936(+) m6A CDS       25683224//25456834//25412662//24981863//25569111//22575960 chr10:99263941-99263942(+) m6A CDS       25683224//25456834//25412662//24981863//25569111//22575960 chr10:99264013-99264014(+) m6A CDS       25683224//25456834//25412662//24981863//25569111 chr10:99264053-99264054(+) m6A CDS       25683224//25456834//25412662//24981863//25569111 chr10:99264587-99264588(+) m6A CDS       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr10:99264666-99264667(+) m6A CDS       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr10:99264678-99264679(+) m6A CDS       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr10:99264702-99264703(+) m6A CDS       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr10:99264720-99264721(+) m6A CDS       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr10:99264804-99264805(+) m6A CDS       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr10:99264942-99264943(+) m6A CDS       25683224//25456834//24981863//25569111//22608085 chr10:99266009-99266010(+) m6A CDS       25683224//25456834//24981863//25569111//22608085 chr10:99266188-99266189(+) m6A CDS       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr10:99266196-99266197(+) m6A CDS       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr10:99266279-99266280(+) m6A CDS       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr10:99266428-99266429(+) m6A 3'UTR       25683224//25456834//24981863//25569111//22608085 chr10:99266500-99266501(+) m6A 3'UTR       25683224//25456834//24981863//25569111//22608085 chr10:99266505-99266506(+) m6A 3'UTR       25683224//25456834//24981863//25569111//22608085 chr10:99266566-99266567(+) m6A 3'UTR       25683224//25456834//24981863//25569111//22608085//22575960 chr10:99266571-99266572(+) m6A 3'UTR       25683224//25456834//24981863//25569111//22608085//22575960 chr10:99266607-99266608(+) m6A 3'UTR       25683224//25456834//24981863//25569111//22608085//22575960 chr10:99266661-99266662(+) m6A 3'UTR       25683224//25456834//24981863//25569111//22608085 chr10:99266690-99266691(+) m6A 3'UTR       25683224//25456834//24981863//25569111//22608085 chr10:99266761-99266762(+) m6A 3'UTR       25683224//25456834//24981863 chr10:99266776-99266777(+) m6A 3'UTR       25683224//24981863 chr10:99267026-99267027(+) m6A 3'UTR       25683224//22608085 chr10:99267162-99267163(+) m6A 3'UTR       25683224//22608085 chr10:99267220-99267221(+) m6A 3'UTR       25683224//22608085 chr10:99267314-99267315(+) m6A 3'UTR       25683224//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-199a-3p	Exosome Conditioned medium of E13 SMG     28041903 Exosome B6 BMDCs     22031862

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-199a-3p
Interactor2: Dusp6

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	20643939	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	NIH3T3 cells	Interactor2 expression	Downregulation
Description	All of the regulated genes in Fig. 5B are down-regulated by miR-199a-3p mimic and up-regulated by miR-199a-3p inhibitor compared with the negative transfection control, with the exception of ITGA6, which is only up-regulated by the inhibitor (Dataset S3).