Basic Information:

  VIRBase ID:  

HHID00076376

  Virus:  

Murid betaherpesvirus 1

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-199a-3p:  MIMAT0000230          Psmd6:  NM_025550     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-199a-3p	Psmd6
miRBase Accession/Entrez ID	MIMAT0000230	66413
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	2400006A19Rik

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Psmd6	chr14:14112326-14112327(-) m6A CDS       24981863//22608085 chr14:14112338-14112339(-) m6A CDS       24981863//22608085 chr14:14112354-14112355(-) m6A CDS       24981863//22608085 chr14:14112371-14112372(-) m6A CDS       24981863//22608085 chr14:14120740-14120741(-) m6A CDS//exon       24981863//25569111//22608085 chr14:14120842-14120843(-) m6A CDS//exon       24981863//25569111//22608085 chr14:14120853-14120854(-) m6A CDS//exon       24981863//25569111//22608085 chr14:14120860-14120861(-) m1A CDS//exon       26863196 chr14:14120869-14120870(-) m6A CDS//exon       24981863//25569111 chr14:14120961-14120962(-) m6A 5'UTR       25569111 chr14:14120978-14120979(-) m6A 5'UTR       25569111

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-199a-3p	Exosome Conditioned medium of E13 SMG     28041903 Exosome B6 BMDCs     22031862
	Psmd6	Nucleus Neuroblastoma cell line (N2A)     22406755

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-199a-3p
Interactor2: Psmd6

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	20643939	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	NIH3T3 cells	Interactor2 expression	Downregulation
Description	All of the regulated genes in Fig. 5B are down-regulated by miR-199a-3p mimic and up-regulated by miR-199a-3p inhibitor compared with the negative transfection control, with the exception of ITGA6, which is only up-regulated by the inhibitor (Dataset S3).