Basic Information:

  VIRBase ID:  

HHID00076369

  Virus:  

Murid betaherpesvirus 1

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-199a-3p:  MIMAT0000230          Emc6:  NM_025318     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-199a-3p	Emc6
miRBase Accession/Entrez ID	MIMAT0000230	66048
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	0610009E20Rik//0610025L18Rik//Tmem93

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Emc6	chr11:73176031-73176032(-) m6A 3'UTR       24981863 chr11:73176076-73176077(-) m6A 3'UTR       24981863 chr11:73176238-73176239(-) m6A 3'UTR       25456834//24981863//25569111//22608085//22575960 chr11:73176305-73176306(-) m6A 3'UTR       25456834//24981863//25569111//22608085//22575960 chr11:73176345-73176346(-) m6A 3'UTR       25456834//24981863//25569111//26404942//22608085//22575960 chr11:73176402-73176403(-) m6A CDS       25456834//24981863//25569111//26404942//22608085//22575960 chr11:73176457-73176458(-) m6A CDS       25456834//24981863//25569111//26404942//22575960 chr11:73176479-73176480(-) m6A CDS       24981863//25569111//22575960 chr11:73176612-73176613(-) m6A CDS       25412662//24981863//25569111 chr11:73176959-73176960(-) m6A 5'UTR       25683224//25412662//24981863//25569111 chr11:73176968-73176969(-) m6A 5'UTR       25683224//25412662//24981863//25569111 chr11:73176995-73176996(-) m6A 5'UTR       25412662//24981863//25569111

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-199a-3p	Exosome Conditioned medium of E13 SMG     28041903 Exosome B6 BMDCs     22031862

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-199a-3p
Interactor2: Emc6

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	20643939	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	NIH3T3 cells	Interactor2 expression	Downregulation
Description	All of the regulated genes in Fig. 5B are down-regulated by miR-199a-3p mimic and up-regulated by miR-199a-3p inhibitor compared with the negative transfection control, with the exception of ITGA6, which is only up-regulated by the inhibitor (Dataset S3).