Basic Information:

  VIRBase ID:  

HHID00076357

  Virus:  

Murid betaherpesvirus 1

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-199a-3p:  MIMAT0000230          Socs6:  NM_018821     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-199a-3p	Socs6
miRBase Accession/Entrez ID	MIMAT0000230	54607
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	1500012M23Rik//5830401B18Rik//AI447482//CI//Cis//Cis4//Cish4//HSPC0//HSPC060//S//So//SOC//SOCS-4//SOCS-6//Socs4//SSI4//ST//STA//STAI4//STATI4

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Socs6	chr18:88866498-88866499(-) m6A 3'UTR//intron       24981863 chr18:88866505-88866506(-) m6A 3'UTR//intron       24981863 chr18:88866530-88866531(-) m6A 3'UTR//intron       24981863 chr18:88866563-88866564(-) m6A 3'UTR//intron       24981863 chr18:88866572-88866573(-) m6A 3'UTR//intron       24981863 chr18:88866577-88866578(-) m6A 3'UTR//intron       24981863 chr18:88866582-88866583(-) m6A 3'UTR//intron       24981863 chr18:88866587-88866588(-) m6A 3'UTR//intron       24981863 chr18:88866592-88866593(-) m6A 3'UTR//intron       24981863 chr18:88866597-88866598(-) m6A 3'UTR//intron       24981863 chr18:88866602-88866603(-) m6A 3'UTR//intron       24981863 chr18:88869122-88869123(-) m6A 3'UTR//intron       25456834//24981863//25569111//22608085//22575960 chr18:88869141-88869142(-) m6A 3'UTR//intron       25683224//25456834//24981863//25569111//22608085//22575960 chr18:88869146-88869147(-) m6A 3'UTR//intron       25683224//25456834//24981863//25569111//22608085//22575960 chr18:88869224-88869225(-) m6A CDS//intron       25683224//25456834//24981863//25569111//22608085//22575960 chr18:88869238-88869239(-) m6A CDS//intron       25683224//25456834//24981863//25569111//22608085//22575960 chr18:88869251-88869252(-) m6A CDS//intron       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr18:88869337-88869338(-) m6A CDS//intron       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr18:88869404-88869405(-) m6A CDS//intron       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr18:88869463-88869464(-) m6A CDS//intron       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr18:88869513-88869514(-) m6A CDS//intron       25683224//25456834//24981863//25569111//22608085 chr18:88869652-88869653(-) m6A CDS//intron       25683224//25456834//24981863//25569111//22608085 chr18:88869797-88869798(-) m6A CDS//intron       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr18:88869821-88869822(-) m6A CDS//intron       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr18:88869938-88869939(-) m6A CDS//intron       25683224//25456834//25412662//24981863//25569111 chr18:88869980-88869981(-) m6A CDS//intron       25683224//25456834//25412662//24981863//25569111 chr18:88869986-88869987(-) m6A CDS//intron       25683224//25456834//25412662//24981863//25569111 chr18:88870139-88870140(-) m6A CDS//intron       25683224//25456834//25412662//24981863//25569111 chr18:88870153-88870154(-) m6A CDS//intron       25683224//25456834//25412662//24981863//25569111 chr18:88870174-88870175(-) m6A CDS//intron       25683224//25456834//25412662//24981863//25569111 chr18:88870196-88870197(-) m6A CDS//intron       25683224//25456834//25412662//24981863//25569111 chr18:88870250-88870251(-) m6A CDS//intron       25683224//25456834//25412662//24981863//25569111//22608085 chr18:88870306-88870307(-) m6A CDS//intron       25683224//25456834//25412662//24981863//25569111 chr18:88870496-88870497(-) m6A CDS//intron       25683224//25412662//24981863//25456834 chr18:88870533-88870534(-) m6A CDS//intron       25683224//25456834//25412662//24981863//25569111 chr18:88870595-88870596(-) m6A CDS//intron       25683224//25456834//25412662//24981863//25569111//22608085 chr18:88870640-88870641(-) m6A CDS//intron       25683224//25456834//25412662//24981863//25569111//22608085 chr18:88870725-88870726(-) m6A CDS//intron       25683224//25456834//25412662//24981863//25569111 chr18:88870767-88870768(-) m6A CDS//intron       25412662//24981863//25569111 chr18:88870827-88870828(-) m6A 5'UTR//intron       24981863//25569111 chr18:88887277-88887278(-) m6A 5'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-199a-3p	Exosome Conditioned medium of E13 SMG     28041903 Exosome B6 BMDCs     22031862

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-199a-3p
Interactor2: Socs6

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	20643939	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	NIH3T3 cells	Interactor2 expression	Downregulation
Description	All of the regulated genes in Fig. 5B are down-regulated by miR-199a-3p mimic and up-regulated by miR-199a-3p inhibitor compared with the negative transfection control, with the exception of ITGA6, which is only up-regulated by the inhibitor (Dataset S3).