Detail

Basic Information:

VIRBase ID:

HHID00076318

Virus:

Murid betaherpesvirus 1

Host:

Mus musculus

Confidence Score:

0.5711

Interaction Type:

Host-Host interaction

Predicted Binding:

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-199a-3p	Tra2b
miRBase Accession/Entrez ID	MIMAT0000230	20462
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	5730405G21Rik//D16Ertd266e//Sfr//Sfrs10//SIG-41//Sil//Silg41//TRA2beta

RNA Modification:

Resource

Symbol

ModificationPosition

Type

Genomic Context

PMID

RMBase

Tra2b

chr16:22246065-22246066(-)	m6A	3'UTR	24981863//25569111//22608085
chr16:22246088-22246089(-)	m6A	3'UTR	24981863//25569111//22608085
chr16:22248453-22248454(-)	m6A	3'UTR//CDS//exon	25412662//24981863//22608085
chr16:22249070-22249071(-)	m6A	3'UTR//CDS//exon	24981863//22608085
chr16:22249112-22249113(-)	m6A	3'UTR//CDS//exon	24981863//22608085
chr16:22250872-22250873(-)	m6A	3'UTR//CDS//exon	22608085
chr16:22255137-22255138(-)	m6A	5'UTR//intron	25412662//22608085
chr16:22255154-22255155(-)	m6A	5'UTR//intron	25412662//22608085
chr16:22259132-22259133(-)	m6A	3'UTR//exon//intron	24981863
chr16:22265753-22265754(-)	m6A	CDS//exon	25412662//24981863//25569111
chr16:22265923-22265924(-)	m6A	5'UTR	25412662//24981863//25456834//25569111
chr16:22265963-22265964(-)	m6A	5'UTR	25412662//24981863//25456834//25569111

RNA Localization:

Resource

Symbol

Subcellular Localization

Tissue or Cell Line

PMID

RNALocate

mmu-miR-199a-3p

Exosome	Conditioned medium of E13 SMG	28041903
Exosome	B6 BMDCs	22031862

Tra2b

Nucleus

Neuroblastoma cell line (N2A)

22406755

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-199a-3p

Interactor2: Tra2b

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	20643939	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	NIH3T3 cells	Interactor2 expression	Downregulation
Description	All of the regulated genes in Fig. 5B are down-regulated by miR-199a-3p mimic and up-regulated by miR-199a-3p inhibitor compared with the negative transfection control, with the exception of ITGA6, which is only up-regulated by the inhibitor (Dataset S3).