Basic Information:

  VIRBase ID:  

HHID00076311

  Virus:  

Murid betaherpesvirus 1

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-199a-3p:  MIMAT0000230          Ccl2:  NM_011333     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-199a-3p	Ccl2
miRBase Accession/Entrez ID	MIMAT0000230	20296
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	AI323594//HC11//JE//MCA//MCAF//MCP//MCP-//MCP-1//MCP1//Scy//Scya2//Sig//Sigje//SMC-C//SMC-CF

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Ccl2	chr11:82036649-82036650(+) m6A exon//intron       24981863 chr11:82036886-82036887(+) m6A exon//intron       24981863 chr11:82036891-82036892(+) m6A exon//intron       24981863 chr11:82036983-82036984(+) m6A CDS//exon       24981863 chr11:82036996-82036997(+) m6A CDS//exon       24981863 chr11:82037008-82037009(+) m6A CDS//exon       24981863 chr11:82037024-82037025(+) m6A CDS//exon       24981863 chr11:82037043-82037044(+) m6A CDS//exon       24981863//25569111 chr11:82037173-82037174(+) m6A CDS//exon       25683224//24981863//25569111 chr11:82037188-82037189(+) m6A 3'UTR//exon       25683224//24981863//25569111 chr11:82037213-82037214(+) m6A 3'UTR//exon       25683224//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-199a-3p	Exosome Conditioned medium of E13 SMG     28041903 Exosome B6 BMDCs     22031862
	Ccl2	Axon Motor neurons     24152552

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-199a-3p
Interactor2: Ccl2

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	20643939	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	NIH3T3 cells	Interactor2 expression	Downregulation
Description	All of the regulated genes in Fig. 5B are down-regulated by miR-199a-3p mimic and up-regulated by miR-199a-3p inhibitor compared with the negative transfection control, with the exception of ITGA6, which is only up-regulated by the inhibitor (Dataset S3).